Dietary Acid Load and Potassium Intake Associate with Blood Pressure and Hypertension Prevalence in a Representative Sample of the German Adult Population

Diets rich in fruits and vegetables, like the Dietary Approaches to Stop Hypertension (DASH)-diet, are usually characterized by high potassium intake and reduced dietary acid load, and have been shown to reduce blood pressure (BP). However, the relevance of potential renal acid load (PRAL) for BP ha...

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Bibliographic Details
Published in:	Nutrients Vol. 10; no. 1; p. 103
Main Authors:	Krupp, Danika, Esche, Jonas, Mensink, Gert Bernardus Maria, Klenow, Stefanie, Thamm, Michael, Remer, Thomas
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 19-01-2018 MDPI
Subjects:	Acids Acids - administration & dosage Adolescent Adult Adults Aged Biomarkers - urine Blood Pressure Body mass Body Mass Index Body size Comparative analysis Cross-Sectional Studies DEGS1 dietary acid load Dietary Approaches To Stop Hypertension Drugs Estimates European Continental Ancestry Group Female Fruit Germany Humans Hypertension Hypertension - epidemiology Hypertension - urine Kidney - metabolism Male Middle Aged Nutrition Assessment Potassium potassium intake Potassium, Dietary - administration & dosage PRAL Prevalence Regression analysis Sodium Sodium, Dietary - administration & dosage Sodium, Dietary - adverse effects Surveys and Questionnaires Urine Vegetables Young Adult PRAL blood pressure DEGS1 dietary acid load hypertension potassium intake
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Summary:	Diets rich in fruits and vegetables, like the Dietary Approaches to Stop Hypertension (DASH)-diet, are usually characterized by high potassium intake and reduced dietary acid load, and have been shown to reduce blood pressure (BP). However, the relevance of potential renal acid load (PRAL) for BP has not been compared with the relevance to BP of urinary biomarker (K-urine)- and dietary food frequency questionnaire (K-FFQ)-based estimates of potassium intake in a general adult population sample. For 6788 participants (aged 18-79 years) of the representative German Health-Interview and Examination Survey for Adults (DEGS1), associations of PRAL, K-urine, and K-FFQ with BP and hypertension prevalence were cross-sectionally examined in multivariable linear and logistic regression models. PRAL was significantly associated with higher systolic BP ( = 0.0002) and higher hypertension prevalence (Odds ratio [OR] high vs. low PRAL = 1.45, = 0.0004) in models adjusted for age, sex, body mass index (BMI), estimated sodium intake, kidney function, relevant medication, and further important covariates. Higher estimates of K-FFQ and K-urine were related to lower systolic BP ( = 0.04 and < 0.0001) and lower hypertension prevalence (OR = 0.82, = 0.04 and OR = 0.77, = 0.02) as well as a lower diastolic BP ( = 0.03 and = 0.0003). Our results show, for the first time in a comparative analysis of a large representative population sample, significant relationships of BP and hypertension prevalence with questionnaire- and biomarker-based estimates of potassium intake and with an estimate of dietary acid load.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work as principal investigators (D.K., J.E.) and as senior author (T.R.).
ISSN:	2072-6643 2072-6643
DOI:	10.3390/nu10010103