Search Results - "Mensah, Lawrence B"

Flow induces epithelial-mesenchymal transition, cellular heterogeneity and biomarker modulation in 3D ovarian cancer nodules by Rizvi, Imran, Gurkan, Umut A, Tasoglu, Savas, Alagic, Nermina, Celli, Jonathan P, Mensah, Lawrence B, Mai, Zhiming, Demirci, Utkan, Hasan, Tayyaba

“…Seventy-five percent of patients with epithelial ovarian cancer present with advanced-stage disease that is extensively disseminated intraperitoneally and…”
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Selective treatment and monitoring of disseminated cancer micrometastases in vivo using dual-function, activatable immunoconjugates by Spring, Bryan Q., Abu-Yousif, Adnan O., Palanisami, Akilan, Rizvi, Imran, Zheng, Xiang, Mai, Zhiming, Anbil, Sriram, Sears, R. Bryan, Mensah, Lawrence B., Goldschmidt, Ruth, Erdem, S. Sibel

“…Drug-resistant micrometastases that escape standard therapies often go undetected until the emergence of lethal recurrent disease. Here, we show that it is…”
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Simultaneous delivery of cytotoxic and biologic therapeutics using nanophotoactivatable liposomes enhances treatment efficacy in a mouse model of pancreatic cancer by Tangutoori, Shifalika, PhD, Spring, Bryan Q., PhD, Mai, Zhiming, PhD, Palanisami, Akilan, PhD, Mensah, Lawrence B., PhD, Hasan, Tayyaba, PhD

“…Abstract A lack of intracellular delivery systems has limited the use of biologics such as monoclonal antibodies (mAb) that abrogate molecular signaling…”
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Layer‐by‐layer nanoparticles for novel delivery of cisplatin and PARP inhibitors for platinum‐based drug resistance therapy in ovarian cancer by Mensah, Lawrence B., Morton, Stephen W., Li, Jiahe, Xiao, Haihua, Quadir, Mohiuddin A., Elias, Kevin M., Penn, Emily, Richson, Aysen K., Ghoroghchian, Paiman Peter, Liu, Joyce, Hammond, Paula T.

“…Advanced staged high‐grade serous ovarian cancer (HGSOC) is the leading cause of gynecological cancer death in the developed world, with 5‐year survival rates…”
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Fine-Tuning of PI3K/AKT Signalling by the Tumour Suppressor PTEN Is Required for Maintenance of Flight Muscle Function and Mitochondrial Integrity in Ageing Adult Drosophila melanogaster by Mensah, Lawrence B, Davison, Claire, Fan, Shih-Jung, Morris, John F, Goberdhan, Deborah C I, Wilson, Clive

“…Insulin/insulin-like growth factor signalling (IIS), acting primarily through the PI3-kinase (PI3K)/AKT kinase signalling cassette, plays key evolutionarily…”
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Genetic determinants of phosphate response in Drosophila by Bergwitz, Clemens, Wee, Mark J, Sinha, Sumi, Huang, Joanne, DeRobertis, Charles, Mensah, Lawrence B, Cohen, Jonathan, Friedman, Adam, Kulkarni, Meghana, Hu, Yanhui, Vinayagam, Arunachalam, Schnall-Levin, Michael, Berger, Bonnie, Perkins, Lizabeth A, Mohr, Stephanie E, Perrimon, Norbert

“…Phosphate is required for many important cellular processes and having too little phosphate or too much can cause disease and reduce life span in humans…”
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mTORC1 signalling mediates PI3K-dependent large lipid droplet accumulation in Drosophila ovarian nurse cells by Mensah, Lawrence B, Goberdhan, Deborah C I, Wilson, Clive

“…Insulin and insulin-like growth factor signalling (IIS), which is primarily mediated by the PI3-kinase (PI3K)/PTEN/Akt kinase signalling cassette, is a highly…”
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Ligand-decorated click polypeptide derived nanoparticles for targeted drug delivery applications by Quadir, Mohiuddin A, Morton, Stephen W, Mensah, Lawrence B, Shopsowitz, Kevin, Dobbelaar, Jeroen, Effenberger, Nicole, Hammond, Paula T

“…Abstract A ligand decorated, synthetic polypeptide block copolymer platform with environment-responsive capabilities was designed. We evaluated the potential…”
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Flow induces epithelial-mesenchymal transition, cellular heterogeneity and biomarker modulation in 3D ovarian cancer nodules by Rizvi, Imran, Gurkan, Umut A., Tasoglu, Savas, Alagic, Nermina, Celli, Jonathan P., Mensah, Lawrence B., Mai, Zhiming, Demirci, Utkan, Hasan, Tayyaba

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Fine-Tuning of PI3K/AKT Signalling by the Tumour Suppressor PTEN Is Required for Maintenance of Flight Muscle Function and Mitochondrial Integrity in Ageing Adult Drosophila melanogaster: e0143818 by Mensah, Lawrence B, Davison, Claire, Fan, Shih-Jung, Morris, John F, Goberdhan, Deborah CI, Wilson, Clive

“…Insulin/insulin-like growth factor signalling (IIS), acting primarily through the PI3-kinase (PI3K)/AKT kinase signalling cassette, plays key evolutionarily…”
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Genetic Determinants of Phosphate Response in Drosophila. e56753 by Bergwitz, Clemens, Wee, Mark J, Sinha, Sumi, Huang, Joanne, DeRobertis, Charles, Mensah, Lawrence B, Cohen, Jonathan, Friedman, Adam, Kulkarni, Meghana, Hu, Yanhui

“…Phosphate is required for many important cellular processes and having too little phosphate or too much can cause disease and reduce life span in humans…”
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