Search Results - "Menoret, Severine"

Humanization of Immunodeficient Animals for the Modeling of Transplantation, Graft Versus Host Disease, and Regenerative Medicine by Adigbli, George, Ménoret, Séverine, Cross, Amy R., Hester, Joanna, Issa, Fadi, Anegon, Ignacio

“…The humanization of animals is a powerful tool for the exploration of human disease pathogenesis in biomedical research, as well as for the development of…”
Get full text

Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases by Geurts, Aron M, Cost, Gregory J, Freyvert, Yevgeniy, Zeitler, Bryan, Miller, Jeffrey C, Choi, Vivian M, Jenkins, Shirin S, Wood, Adam, Cui, Xiaoxia, Meng, Xiangdong, Vincent, Anna, Lam, Stephen, Michalkiewicz, Mieczyslaw, Schilling, Rebecca, Foeckler, Jamie, Kalloway, Shawn, Weiler, Hartmut, Ménoret, Séverine, Anegon, Ignacio, Davis, Gregory D, Zhang, Lei, Rebar, Edward J, Gregory, Philip D, Urnov, Fyodor D, Jacob, Howard J, Buelow, Roland

“…The toolbox of rat genetics currently lacks the ability to introduce site-directed, heritable mutations into the genome to create knockout animals. By using…”
Get full text

Improved Genome Editing Efficiency and Flexibility Using Modified Oligonucleotides with TALEN and CRISPR-Cas9 Nucleases by Renaud, Jean-Baptiste, Boix, Charlotte, Charpentier, Marine, De Cian, Anne, Cochennec, Julien, Duvernois-Berthet, Evelyne, Perrouault, Loïc, Tesson, Laurent, Edouard, Joanne, Thinard, Reynald, Cherifi, Yacine, Menoret, Séverine, Fontanière, Sandra, de Crozé, Noémie, Fraichard, Alexandre, Sohm, Frédéric, Anegon, Ignacio, Concordet, Jean-Paul, Giovannangeli, Carine

“…Genome editing has now been reported in many systems using TALEN and CRISPR-Cas9 nucleases. Precise mutations can be introduced during homology-directed repair…”
Get full text

Knockout rats generated by embryo microinjection of TALENs by Tesson, Laurent, Usal, Claire, Ménoret, Séverine, Leung, Elo, Niles, Brett J, Remy, Séverine, Santiago, Yolanda, Vincent, Anna I, Meng, Xiangdong, Zhang, Lei, Gregory, Philip D, Anegon, Ignacio, Cost, Gregory J

Get full text

Efficient generation of human immune system rats using human CD34+ cells by Ménoret, Séverine, Renart-Depontieu, Florence, Martin, Gaelle, Thiam, Kader, Anegon, Ignacio

“…Human immune system (HIS) mice generated using human CD34+ hematopoietic stem cells serve as a pivotal model for the in vivo evaluation of immunotherapies for…”
Get full text

Advances in Genome Editing and Application to the Generation of Genetically Modified Rat Models by Chenouard, Vanessa, Remy, Séverine, Tesson, Laurent, Ménoret, Séverine, Ouisse, Laure-Hélène, Cherifi, Yacine, Anegon, Ignacio

“…The rat has been extensively used as a small animal model. Many genetically engineered rat models have emerged in the last two decades, and the advent of…”
Get full text

In Vivo Analysis of Human Immune Responses in Immunodeficient Rats by Ménoret, Séverine, Ouisse, Laure-Hélène, Tesson, Laurent, Remy, Séverine, Usal, Claire, Guiffes, Aude, Chenouard, Vanessa, Royer, Pierre-Joseph, Evanno, Gwenaelle, Vanhove, Bernard, Piaggio, Eliane, Anegon, Ignacio

“…BACKGROUND.Humanized immune system immunodeficient mice have been extremely useful for the in vivo analyses of immune responses in a variety of models,…”
Get full text

Cryopreserved cGMP-compliant human pluripotent stem cell-derived hepatic progenitors rescue mice from acute liver failure through rapid paracrine effects on liver cells by Gantier, Malika, Rispal, Raphaël, Fourrier, Angélique, Ménoret, Séverine, Delbos, Frédéric, Anegon, Ignacio, Nguyen, Tuan Huy

“…Liver transplantation remains the only curative treatment for end-stage liver diseases. Unfortunately, there is a drastic organ donor shortage. Hepatocyte…”
Get full text

Zinc-finger nucleases: a powerful tool for genetic engineering of animals by Rémy, Séverine, Tesson, Laurent, Ménoret, Séverine, Usal, Claire, Scharenberg, Andrew M, Anegon, Ignacio

“…The generation of genetically modified animals or plants with gene-targeted deletions or modifications is a powerful tool to analyze gene function, study…”
Get full text

Homology-directed repair in rodent zygotes using Cas9 and TALEN engineered proteins by Ménoret, Séverine, De Cian, Anne, Tesson, Laurent, Remy, Séverine, Usal, Claire, Boulé, Jean-Baptiste, Boix, Charlotte, Fontanière, Sandra, Crénéguy, Alison, Nguyen, Tuan H., Brusselle, Lucas, Thinard, Reynald, Gauguier, Dominique, Concordet, Jean-Paul, Cherifi, Yacine, Fraichard, Alexandre, Giovannangeli, Carine, Anegon, Ignacio

“…The generation of genetically-modified organisms has been revolutionized by the development of new genome editing technologies based on the use of…”
Get full text

Efficient gene targeting by homology-directed repair in rat zygotes using TALE nucleases by Remy, Séverine, Tesson, Laurent, Menoret, Séverine, Usal, Claire, De Cian, Anne, Thepenier, Virginie, Thinard, Reynald, Baron, Daniel, Charpentier, Marine, Renaud, Jean-Baptiste, Buelow, Roland, Cost, Gregory J, Giovannangeli, Carine, Fraichard, Alexandre, Concordet, Jean-Paul, Anegon, Ignacio

“…The generation of genetically modified animals is important for both research and commercial purposes. The rat is an important model organism that until…”
Get full text

Generation of gene-edited rats by delivery of CRISPR/Cas9 protein and donor DNA into intact zygotes using electroporation by Remy, Séverine, Chenouard, Vanessa, Tesson, Laurent, Usal, Claire, Ménoret, Séverine, Brusselle, Lucas, Heslan, Jean-Marie, Nguyen, Tuan Huan, Bellien, Jeremy, Merot, Jean, De Cian, Anne, Giovannangeli, Carine, Concordet, Jean-Paul, Anegon, Ignacio

“…The generation of gene-edited animals using the CRISPRs/Cas9 system is based on microinjection into zygotes which is inefficient, time consuming and demands…”
Get full text

Generation of immunodeficient rats with Rag1 and Il2rg gene deletions and human tissue grafting models by Ménoret, Séverine, Ouisse, Laure-Hélène, Tesson, Laurent, Delbos, Frédéric, Garnier, Delphine, Remy, Séverine, Usal, Claire, Concordet, Jean-Paul, Giovannangeli, Carine, Chenouard, Vanessa, Brusselle, Lucas, Merieau, Emmanuel, Nerrière-Daguin, Véronique, Duteille, Franck, Bellier-Waast, Frédérique, Fraichard, Alexandre, Nguyen, Tuan H, Anegon, Ignacio

“…BACKGROUNDImmunodeficient mice are invaluable tools to analyze the long-term effects of potentially immunogenic molecules in the absence of adaptive immune…”
Get full text

CD4 + and CD8 + regulatory T cell characterization in the rat using a unique transgenic Foxp3-EGFP model by Ménoret, Séverine, Tesson, Laurent, Remy, Séverine, Gourain, Victor, Sérazin, Céline, Usal, Claire, Guiffes, Aude, Chenouard, Vanessa, Ouisse, Laure-Hélène, Gantier, Malika, Heslan, Jean-Marie, Fourgeux, Cynthia, Poschmann, Jeremie, Guillonneau, Carole, Anegon, Ignacio

“…Regulatory T cells (Treg) in diverse species include CD4 and CD8 T cells. In all species, CD8 Treg have been only partially characterized and there is no rat…”
Get full text

Changes in social behavior with MAPK2 and KCTD13/CUL3 pathways alterations in two new outbred rat models for the 16p11.2 syndromes with autism spectrum disorders by Martin Lorenzo, Sandra, Muniz Moreno, Maria Del Mar, Atas, Helin, Pellen, Marion, Nalesso, Valérie, Raffelsberger, Wolfgang, Prevost, Geraldine, Lindner, Loic, Birling, Marie-Christine, Menoret, Séverine, Tesson, Laurent, Negroni, Luc, Concordet, Jean-Paul, Anegon, Ignacio, Herault, Yann

“…Copy number variations (CNVs) of the human 16p11.2 locus are associated with several developmental/neurocognitive syndromes. Particularly, deletion and…”
Get full text

Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy-like Autoimmune Disease by Ossart, Jason, Moreau, Anne, Autrusseau, Elodie, Ménoret, Séverine, Martin, Jérôme C, Besnard, Marine, Ouisse, Laure-Hélène, Tesson, Laurent, Flippe, Léa, Kisand, Kai, Peterson, Pärt, Hubert, François-Xavier, Anegon, Ignacio, Josien, Régis, Guillonneau, Carole

“…Autoimmune regulator (AIRE) deficiency in humans induces a life-threatening generalized autoimmune disease called autoimmune…”
Get full text

Generation of Rag1‐knockout immunodeficient rats and mice using engineered meganucleases by Ménoret, Séverine, Fontanière, Sandra, Jantz, Derek, Tesson, Laurent, Thinard, Reynald, Rémy, Séverine, Usal, Claire, Ouisse, Laure‐Hélène, Fraichard, Alexandre, Anegon, Ignacio

“…Despite the recent availability of gene‐specific nucleases, such as zinc‐finger nucleases (ZFNs) and transcription activator‐like nucleases (TALENs), there is…”
Get full text

A rat model expressing a human amyloidogenic kappa light chain by Ayala, Maria Victoria, Bender, Sébastien, Anegon, Ignacio, Menoret, Séverine, Bridoux, Frank, Jaccard, Arnaud, Sirac, Christophe

Get full text

Characterization of immunoglobulin heavy chain knockout rats by Ménoret, Séverine, Iscache, Anne-L, Tesson, Laurent, Rémy, Séverine, Usal, Claire, Osborn, Michel J, Cost, Gregory J, Brüggemann, Marianne, Buelow, Roland, Anegon, Ignacio

“…The rat is a species frequently used in immunological studies but, until now, there were no models with introduced gene-specific mutations. In a recent study,…”
Get full text

Fibrinogen-like protein 2/fibroleukin induces long-term allograft survival in a rat model through regulatory B cells by Bézie, Séverine, Picarda, Elodie, Tesson, Laurent, Renaudin, Karine, Durand, Justine, Ménoret, Séverine, Mérieau, Emmanuel, Chiffoleau, Elise, Guillonneau, Carole, Caron, Lise, Anegon, Ignacio

“…We previously described that in a rat model of heart transplantation tolerance was dependent on CD8+CD45RClow Tregs that over-expressed fibrinogen-like protein…”
Get full text