Search Results - "Menon, Usha N"

Associations between CYP2B6 Polymorphisms and Pharmacokinetics after a Single Dose of Nevirapine or Efavirenz in African Americans by Haas, David W., Gebretsadik, Tebeb, Mayo, Gail, Menon, Usha N., Acosta, Edward P., Shintani, Ayumi, Floyd, Michael, Stein, C. Michael, Wilkinson, Grant R.

“…BackgroundPolymorphisms in CYP2B6 affect the steady-state plasma concentrations of nevirapine and efavirenz. In many resource-limited countries, a single dose…”
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A Selective Allosteric Potentiator of the M1 Muscarinic Acetylcholine Receptor Increases Activity of Medial Prefrontal Cortical Neurons and Restores Impairments in Reversal Learning by Shirey, Jana K, Brady, Ashley E, Jones, Paulianda J, Davis, Albert A, Bridges, Thomas M, Kennedy, J. Phillip, Jadhav, Satyawan B, Menon, Usha N, Xiang, Zixiu, Watson, Mona L, Christian, Edward P, Doherty, James J, Quirk, Michael C, Snyder, Dean H, Lah, James J, Levey, Allan I, Nicolle, Michelle M, Lindsley, Craig W, Conn, P. Jeffrey

“…M(1) muscarinic acetylcholine receptors (mAChRs) may represent a viable target for treatment of disorders involving impaired cognitive function. However, a…”
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Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity by Rodriguez, Alice L, Grier, Mark D, Jones, Carrie K, Herman, Elizabeth J, Kane, Alexander S, Smith, Randy L, Williams, Richard, Zhou, Ya, Marlo, Joy E, Days, Emily L, Blatt, Tasha N, Jadhav, Satyawan, Menon, Usha N, Vinson, Paige N, Rook, Jerri M, Stauffer, Shaun R, Niswender, Colleen M, Lindsley, Craig W, Weaver, C David, Conn, P Jeffrey

“…Modulators of metabotropic glutamate receptor subtype 5 (mGluR5) may provide novel treatments for multiple central nervous system (CNS) disorders, including…”
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Synthesis and Evaluation of a Series of Heterobiarylamides That Are Centrally Penetrant Metabotropic Glutamate Receptor 4 (mGluR4) Positive Allosteric Modulators (PAMs) by Engers, Darren W, Niswender, Colleen M, Weaver, C. David, Jadhav, Satyawan, Menon, Usha N, Zamorano, Rocio, Conn, P. Jeffrey, Lindsley, Craig W, Hopkins, Corey R

“…We report the synthesis and evaluation of a series of heterobiaryl amides as positive allosteric modulators of mGluR4. Compounds 9b and 9c showed submicromolar…”
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Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor5 (mGlu5): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound by Mueller, Ralf, Dawson, Eric S, Meiler, Jens, Rodriguez, Alice L, Chauder, Brian A, Bates, Brittney S, Felts, Andrew S, Lamb, Jeffrey P, Menon, Usha N, Jadhav, Sataywan B, Kane, Alexander S, Jones, Carrie K, Gregory, Karen J, Niswender, Colleen M, Conn, P. Jeffrey, Olsen, Christopher M, Winder, Danny G, Emmitte, Kyle A, Lindsley, Craig W

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Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor 5 (mGlu5): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound by Mueller, Ralf, Dawson, Eric S., Meiler, Jens, Rodriguez, Alice L., Chauder, Brian A., Bates, Brittney S., Felts, Andrew S., Lamb, Jeffrey P., Menon, Usha N., Jadhav, Sataywan B., Kane, Alexander S., Jones, Carrie K., Gregory, Karen J., Niswender, Colleen M., Conn, P. Jeffrey, Olsen, Christopher M., Winder, Danny G., Emmitte, Kyle A., Lindsley, Craig W.

“…From ANNs to NAMs! Data from an experimental metabotropic glutamate receptor 5 (mGlu5) high‐throughput screen (HTS) were employed to train artificial neural…”
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3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure in rats by Felts, Andrew S, Lindsley, Stacey R, Lamb, Jeffrey P, Rodriguez, Alice L, Menon, Usha N, Jadhav, Satyawan, Jones, Carrie K, Conn, P Jeffrey, Lindsley, Craig W, Emmitte, Kyle A

“…Development of SAR in a 3-cyano-5-fluoro-N-arylbenzamide series of non-competitive antagonists of mGlu(5) using a functional cell-based assay is described in…”
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(3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu(5): Discovery of a new tool compound with activity in the OSS mouse model of addiction by Lindsley, Craig W, Bates, Brittney S, Menon, Usha N, Jadhav, Satyawan B, Kane, Alexander S, Jones, Carrie K, Rodriguez, Alice L, Conn, P Jeffrey, Olsen, Christopher M, Winder, Danny G, Emmitte, Kyle A

“…Glutamate is the major excitatory transmitter in the mammalian CNS, exerting its effects through both ionotropic and metabotropic glutamate receptors. The…”
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(3-Cyano-5-fluorophenyl)biaryl Negative Allosteric Modulators of mGlu5: Discovery of a New Tool Compound with Activity in the OSS Mouse Model of Addiction by Lindsley, Craig W, Bates, Brittney S, Menon, Usha N, Jadhav, Satyawan B, Kane, Alexander S, Jones, Carrie K, Rodriguez, Alice L, Conn, P. Jeffrey, Olsen, Christopher M, Winder, Danny G, Emmitte, Kyle A

“…Glutamate is the major excitatory transmitter in the mammalian central nervous system (CNS), exerting its effects through both ionotropic and metabotropic…”
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Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS) by ENGERS, Darren W, GENTRY, Patrick R, WILLIAMS, Richard, BOLINGER, Julie D, WEAVER, C. David, MENON, Usha N, CONN, P. Jeffrey, LINDSLEY, Craig W, NISWENDER, Colleen M, HOPKINS, Corey R

“…Herein we disclose the synthesis and SAR of a series of 4-(phenylsulfamoyl)phenylacetamide compounds as mGlu(4) positive allosteric modulators (PAMs) that were…”
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3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu5: Identification of easily prepared tool compounds with CNS exposure in rats by Felts, Andrew S., Lindsley, Stacey R., Lamb, Jeffrey P., Rodriguez, Alice L., Menon, Usha N., Jadhav, Satyawan, Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.

“…Development of SAR in a 3-cyano-5-fluoro-N-arylbenzamide series of non-competitive antagonists of mGlu5 using a functional cell-based assay is described in…”
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A Selective Allosteric Potentiator of the M 1 Muscarinic Acetylcholine Receptor Increases Activity of Medial Prefrontal Cortical Neurons and Restores Impairments in Reversal Learning by Shirey, Jana K., Brady, Ashley E., Jones, Paulianda J., Davis, Albert A., Bridges, Thomas M., Kennedy, J. Phillip, Jadhav, Satyawan B., Menon, Usha N., Xiang, Zixiu, Watson, Mona L., Christian, Edward P., Doherty, James J., Quirk, Michael C., Snyder, Dean H., Lah, James J., Levey, Allan I., Nicolle, Michelle M., Lindsley, Craig W., Conn, P. Jeffrey

“…M 1 muscarinic acetylcholine receptors (mAChRs) may represent a viable target for treatment of disorders involving impaired cognitive function. However, a…”
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Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu 4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS) by Engers, Darren W., Gentry, Patrick R., Williams, Richard, Bolinger, Julie D., Weaver, C. David, Menon, Usha N., Conn, P. Jeffrey, Lindsley, Craig W., Niswender, Colleen M., Hopkins, Corey R.

“…Herein we disclose the synthesis and SAR of a series of 4-(phenylsulfamoyl)phenylacetamide compounds as mGlu 4 positive allosteric modulators (PAMs) that were…”
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3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu sub(5): Identification of easily prepared tool compounds with CNS exposure in rats by Felts, Andrew S, Lindsley, Stacey R, Lamb, Jeffrey P, Rodriguez, Alice L, Menon, Usha N, Jadhav, Satyawan, Jones, Carrie K, Conn, PJeffrey, Lindsley, Craig W, Emmitte, Kyle A

“…Development of SAR in a 3-cyano-5-fluoro-N-arylbenzamide series of non-competitive antagonists of mGlu sub(5) using a functional cell-based assay is described…”
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Synthesis and Evaluation of a Series of Heterobiaryl Amides that are Centrally Penetrant Metabotropic Glutamate Receptor 4 (mGluR4) Positive Allosteric Modulators (PAMs) by Engers, Darren W., Niswender, Colleen M., Weaver, C. David, Jadhav, Satyawan, Menon, Usha N., Zamorano, Rocio, Conn, P. Jeffrey, Lindsley, Craig W., Hopkins, Corey R.

“…We report the synthesis and evaluation of a series of heterobiaryl amides as positive allosteric modulators of mGluR4. Compounds 9b and 9c showed submicromolar…”
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Discovery of (2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine mGlu5 NAMs: From Artificial Neural Network Virtual Screen to in vivo Tool Compound by Mueller, Ralf, Dawson, Eric S., Meiler, Jens, Rodriguez, Alice L., Chauder, Brian A., Bates, Brittney S., Felts, Andrew S., Lamb, Jeffrey P., Menon, Usha N., Jadhav, Sataywan B., Kane, Alexander S., Jones, Carrie K., Gregory, Karen J., Niswender, Colleen M., Conn, P. Jeffrey, Olsen, Christopher M., Winder, Danny G., Emmitte, Kyle A., Lindsley, Craig W.

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(3-Cyano-5-fluorophenyl)biaryl Negative Allosteric Modulators of mGlu 5 : Discovery of a New Tool Compound with Activity in the OSS Mouse Model of Addiction by Lindsley, Craig W., Bates, Brittney S., Menon, Usha N., Jadhav, Satyawan B., Kane, Alexander S., Jones, Carrie K., Rodriguez, Alice L., Conn, P. Jeffrey, Olsen, Christopher M., Winder, Danny G., Emmitte, Kyle A.

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A mindful eating intervention: A theory-guided randomized anti-obesity feasibility study with adolescent Latino females by Daly, Patricia, PhD, FNP-BC, Pace, Thaddeus, PhD, Berg, Judith, PhD, WHNP, FAANP, Menon, Usha, PhD, RN, FAAN, Szalacha, Laura A., EdD

“…Highlights • Mindful eating is a theory-based, anti-obesity behavioral skill intervention. • Practicing this behavioral skill may enhance adoption of healthy…”
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