Search Results - "Menon, Rajesh P"

The role of interruptions in polyQ in the pathology of SCA1 by Menon, Rajesh P, Nethisinghe, Suran, Faggiano, Serena, Vannocci, Tommaso, Rezaei, Human, Pemble, Sally, Sweeney, Mary G, Wood, Nicholas W, Davis, Mary B, Pastore, Annalisa, Giunti, Paola

“…At least nine dominant neurodegenerative diseases are caused by expansion of CAG repeats in coding regions of specific genes that result in abnormal elongation…”
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Myosin IIa Promotes Antibody Responses by Regulating B Cell Activation, Acquisition of Antigen, and Proliferation by Hoogeboom, Robbert, Natkanski, Elizabeth M., Nowosad, Carla R., Malinova, Dessislava, Menon, Rajesh P., Casal, Antonio, Tolar, Pavel

“…B cell responses are regulated by antigen acquisition, processing, and presentation to helper T cells. These functions are thought to depend on contractile…”
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Josephin domain of ataxin-3 contains two distinct ubiquitin-binding sites by Nicastro, Giuseppe, Masino, Laura, Esposito, Veronica, Menon, Rajesh P., De Simone, Alfonso, Fraternali, Franca, Pastore, Annalisa

“…Joseph‐Machado is an incurable neurodegenerative disease caused by toxic aggregation of ataxin‐3, a ubiquitin‐specific cysteine protease, involved in the…”
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Protein-protein interactions as a strategy towards protein-specific drug design: the example of ataxin-1 by de Chiara, Cesira, Menon, Rajesh P, Kelly, Geoff, Pastore, Annalisa

“…A main challenge for structural biologists is to understand the mechanisms that discriminate between molecular interactions and determine function. Here, we…”
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The Solution Structure of the Josephin Domain of Ataxin-3: Structural Determinants for Molecular Recognition by Nicastro, Giuseppe, Menon, Rajesh P., Masino, Laura, Knowles, Philip P., McDonald, Neil Q., Pastore, Annalisa, Hendrickson, Wayne A.

“…The Josephin domain plays an important role in the cellular functions of ataxin-3, the protein responsible for the neurodegenerative Machado-Joseph disease. We…”
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Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factors by de Chiara, Cesira, Menon, Rajesh P, Strom, Molly, Gibson, Toby J, Pastore, Annalisa

“…Ataxin-1 (Atx1), a member of the polyglutamine (polyQ) expanded protein family, is responsible for spinocerebellar ataxia type 1. Requirements for developing…”
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The importance of serine 776 in Ataxin-1 partner selection: A FRET Analysis by Menon, Rajesh P., Soong, Daniel, de Chiara, Cesira, Holt, Mark R., Anilkumar, Narayana, Pastore, Annalisa

“…Anomalous expansion of a polymorphic tract in Ataxin-1 causes the autosomal dominant spinocerebellar ataxia type 1. In addition to polyglutamine expansion,…”
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Structural basis for Fc receptor recognition of immunoglobulin M by Chen, Qu, Menon, Rajesh P., Masino, Laura, Tolar, Pavel, Rosenthal, Peter B.

“…Immunoglobulin Fc receptors are cell surface transmembrane proteins that bind to the Fc constant region of antibodies and play critical roles in regulating…”
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Domain architecture of the polyglutamine protein ataxin-3: a globular domain followed by a flexible tail by Masino, Laura, Musi, Valeria, Menon, Rajesh P., Fusi, Paola, Kelly, Geoff, Frenkiel, Thomas A., Trottier, Yvon, Pastore, Annalisa

“…Anomalous expansion of a polyglutamine (polyQ) tract in the protein ataxin-3 causes spinocerebellar ataxia type 3, an autosomal dominant neurodegenerative…”
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Mapping the self-association domains of ataxin-1: identification of novel non overlapping motifs by Menon, Rajesh P, Soong, Daniel, de Chiara, Cesira, Holt, Mark, McCormick, John E, Anilkumar, Narayana, Pastore, Annalisa

“…The neurodegenerative disease spinocerebellar ataxia type 1 (SCA1) is caused by aggregation and misfolding of the ataxin-1 protein. While the pathology…”
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Allosteric regulation of deubiquitylase activity through ubiquitination by Faggiano, Serena, Menon, Rajesh P, Kelly, Geoff P, Todi, Sokol V, Scaglione, K Matthew, Konarev, Petr V, Svergun, Dmitri I, Paulson, Henry L, Pastore, Annalisa

“…Ataxin-3, the protein responsible for spinocerebellar ataxia type-3, is a cysteine protease that specifically cleaves poly-ubiquitin chains and participates in…”
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Characterization of the Structure and the Amyloidogenic Properties of the Josephin Domain of the Polyglutamine-containing Protein Ataxin-3 by Masino, Laura, Nicastro, Giuseppe, Menon, Rajesh P., Piaz, Fabrizio Dal, Calder, Lesley, Pastore, Annalisa

“…Expansion of the polyglutamine (polyQ) region in the protein ataxin-3 is associated with spinocerebellar ataxia type 3, an inherited neurodegenerative disorder…”
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The C Terminus of Fragile X Mental Retardation Protein Interacts with the Multi-domain Ran-binding Protein in the Microtubule-organising Centre by Menon, Rajesh P., Gibson, Toby J., Pastore, Annalisa

“…Absence of the fragile X mental retardation protein (FMRP) causes fragile X syndrome, the most common form of hereditary mental retardation. FMRP is a mainly…”
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Polyglutamine is Not All: The Functional Role of the AXH Domain in the Ataxin-1 Protein by de Chiara, Cesira, Menon, Rajesh P., Dal Piaz, Fabrizio, Calder, Lesley, Pastore, Annalisa

“…A family of neurodegenerative diseases is associated with anomalous expansion of a polyglutamine tract in the coding region of the corresponding proteins. The…”
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Specificity of interactions of galectin-3 with Chrp, a cysteine- and histidine-rich cytoplasmic protein by Bawumia, Sulemana, Barboni, Eminia A.M, Menon, Rajesh P, Colin Hughes, R

“…Earlier work described the cloning of a gene from murine 3T3 cells encoding a cytoplasmic protein Chrp containing a cysteine- and histidine-rich motif…”
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Down-regulation of the dopamine receptor D2 in mice lacking ataxin 1 by Goold, Robert, Hubank, Michael, Hunt, Abigail, Holton, Janice, Menon, Rajesh P., Revesz, Tamas, Pandolfo, Massimo, Matilla-Dueñas, Antoni

“…Ataxin 1 (Atxn1) is a protein of unknown function associated with spinocerebellar ataxia type 1 (SCA1), a neurodegenerative disease of late onset with variable…”
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Chemical shift assignment of the ataxin-1 AXH domain in complex with a CIC ligand peptide by de Chiara, Cesira, Kelly, Geoff, Menon, Rajesh P., McCormick, John, Pastore, Annalisa

“…Ataxin-1 is the protein responsible for the genetically-inherited neurodegenerative disease spinocerebellar ataxia type-1 linked to the expansion of a…”
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Structural bases for recognition of Anp32/LANP proteins by de Chiara, Cesira, Menon, Rajesh P, Pastore, Annalisa

“…The leucine-rich repeat acidic nuclear protein (Anp32a/LANP) belongs to a family of evolutionarily-conserved phosphoproteins involved in a complex network of…”
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The AXH domain adopts alternative folds the solution structure of HBP1 AXH by de Chiara, Cesira, Menon, Rajesh P, Adinolfi, Salvatore, de Boer, Jasper, Ktistaki, Eleni, Kelly, Geoff, Calder, Lesley, Kioussis, Dimitris, Pastore, Annalisa

“…AXH is a protein module identified in two unrelated families that comprise the transcriptional repressor HBP1 and ataxin-1 (ATX1), the protein responsible for…”
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Enzymatic production of mono-ubiquitinated proteins for structural studies: The example of the Josephin domain of ataxin-3 by Faggiano, Serena, Menon, Rajesh P., Kelly, Geoff P., McCormick, John, Todi, Sokol V., Scaglione, K. Matthew, Paulson, Henry L., Pastore, Annalisa

“…Protein ubiquitination occurs through formation of an isopeptide bond between the C-terminal glycine of ubiquitin (Ub) and the ɛ-amino group of a substrate…”
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