Search Results - "Menon, David"
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Severe traumatic brain injury: targeted management in the intensive care unit
Published in Lancet neurology (01-06-2017)“…Summary Severe traumatic brain injury (TBI) is currently managed in the intensive care unit with a combined medical–surgical approach. Treatment aims to…”
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Default mode contributions to automated information processing
Published in Proceedings of the National Academy of Sciences - PNAS (28-11-2017)“…Concurrent with mental processes that require rigorous computation and control, a series of automated decisions and actions govern our daily lives, providing…”
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Paroxysmal sympathetic hyperactivity: the storm after acute brain injury
Published in Lancet neurology (01-09-2017)“…A substantial minority of patients who survive an acquired brain injury develop a state of sympathetic hyperactivity that can persist for weeks or months,…”
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The chronic and evolving neurological consequences of traumatic brain injury
Published in Lancet neurology (01-10-2017)“…Traumatic brain injury (TBI) can have lifelong and dynamic effects on health and wellbeing. Research on the long-term consequences emphasises that, for many…”
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Traumatic Axonal Injury: Mechanisms and Translational Opportunities
Published in Trends in neurosciences (Regular ed.) (01-05-2016)“…Traumatic axonal injury (TAI) is an important pathoanatomical subgroup of traumatic brain injury (TBI) and a major driver of mortality and functional…”
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Time for change in acquired brain injury
Published in Lancet neurology (01-01-2019)“…In this context, Time for change,1 the report produced by the UK All-Party Parliamentary Group on Acquired Brain Injury (APPG-ABI), argues for a better link…”
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Ultrasound non-invasive measurement of intracranial pressure in neurointensive care: A prospective observational study
Published in PLoS medicine (25-07-2017)“…The invasive nature of the current methods for monitoring of intracranial pressure (ICP) has prevented their use in many clinical situations. Several attempts…”
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Fractal dimension of cortical functional connectivity networks & severity of disorders of consciousness
Published in PloS one (13-02-2020)“…Recent evidence suggests that the quantity and quality of conscious experience may be a function of the complexity of activity in the brain and that…”
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Changing patterns in the epidemiology of traumatic brain injury
Published in Nature reviews. Neurology (01-04-2013)“…In this Perspectives article, Roozenbeek et al . discuss issues with epidemiological studies in traumatic brain injury (TBI) and variability in the definition…”
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Brain Connectivity Dissociates Responsiveness from Drug Exposure during Propofol-Induced Transitions of Consciousness
Published in PLoS computational biology (01-01-2016)“…Accurately measuring the neural correlates of consciousness is a grand challenge for neuroscience. Despite theoretical advances, developing reliable brain…”
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Default Mode Dynamics for Global Functional Integration
Published in The Journal of neuroscience (18-11-2015)“…The default mode network (DMN) has been traditionally assumed to hinder behavioral performance in externally focused, goal-directed paradigms and to provide no…”
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LSD alters dynamic integration and segregation in the human brain
Published in NeuroImage (Orlando, Fla.) (15-02-2021)“…•LSD untethers functional connectivity from the constraint of structural connectivity.•Increased small-worldness of brain networks predicts LSD-induced…”
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Position Statement: Definition of Traumatic Brain Injury
Published in Archives of physical medicine and rehabilitation (01-11-2010)“…Abstract Menon DK, Schwab K, Wright DW, Maas AI, on behalf of The Demographics and Clinical Assessment Working Group of the International and Interagency…”
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Consciousness-specific dynamic interactions of brain integration and functional diversity
Published in Nature communications (10-10-2019)“…Prominent theories of consciousness emphasise different aspects of neurobiology, such as the integration and diversity of information processing within the…”
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Efficient multi-scale 3D CNN with fully connected CRF for accurate brain lesion segmentation
Published in Medical image analysis (01-02-2017)“…•An efficient 11-layers deep, multi-scale, 3D CNN architecture.•A novel training strategy that significantly boosts performance.•The first employment of a 3D…”
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A Precuneal Causal Loop Mediates External and Internal Information Integration in the Human Brain
Published in The Journal of neuroscience (01-12-2021)“…Human brains interpret external stimuli based on internal representations. One untested hypothesis is that the default-mode network (DMN), widely considered…”
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Serotonergic psychedelics LSD & psilocybin increase the fractal dimension of cortical brain activity in spatial and temporal domains
Published in NeuroImage (Orlando, Fla.) (15-10-2020)“…Psychedelic drugs, such as psilocybin and LSD, represent unique tools for researchers investigating the neural origins of consciousness. Currently, the most…”
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Covert Consciousness in the ICU
Published in Critical care medicine (01-09-2024)“…For critically ill patients with acute severe brain injuries, consciousness may reemerge before behavioral responsiveness. The phenomenon of covert…”
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Spectral signatures of reorganised brain networks in disorders of consciousness
Published in PLoS computational biology (01-10-2014)“…Theoretical advances in the science of consciousness have proposed that it is concomitant with balanced cortical integration and differentiation, enabled by…”
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Boosting the injured brain with supplemental energy fuels
Published in Intensive care medicine (01-06-2019)“…Clinical investigation, using cerebral metabolic assessment with positron emission tomography, magnetic resonance spectroscopy, and regional cerebral…”
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