Search Results - "Menichini, P."

Characterization of apoptosis induced by marine natural products in non small cell lung cancer A549 cells by Catassi, A, Cesario, A, Arzani, D, Menichini, P, Alama, A, Bruzzo, C, Imperatori, A, Rotolo, N, Granone, P, Russo, P

“…The effects of different marine derived agents were studied in A549 cell growth. These drugs induced cell cycle arrest at the G2-M phase associated with the…”
Get full text

PRIMA-1 synergizes with adriamycin to induce cell death in non-small cell lung cancer cells by Magrini, R., Russo, D., Ottaggio, L., Fronza, G., Inga, A., Menichini, P.

“…p53‐dependent apoptosis is important for the efficacy of cancer treatment, and tumors carrying mutant p53 are often resistant to chemotherapy. Non‐small cell…”
Get full text

Perturbation of murine liver cyp-superfamily of isoforms by different combinations of pesticide mixtures by Canistro, D., Pozzetti, L., Sapone, A., Broccoli, M., Affatato, A.A., Stradiotti, A., Longo, V., Menichini, P., Barale, R., Paolini, M.

“…It was previously found that fenarimol, vinclozolin or acephate, three of the most used pesticides worldwide, provoked a marked perturbation of murine…”
Get full text

Lack of mutagenicity and clastogenicity of PNAEμ-NLS targeted to a regulatory sequence of the translocated c- myc oncogene in Burkitt's lymphoma by Boffa, L.C., Menichini, P., Bolognesi, C., Cutrona, G., Roncella, S., Damonte, G.L., Millo, E., Mariani, M.R., Matis, S., Russo, D., Ciliutti, P., Ferrarini, M.

“…Peptide nucleic acids (PNAs) are synthetic homolog of nucleic acids in which the phosphate-sugar polynucleotide backbone is replaced by a flexible polyamide…”
Get full text

Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code by Ciribilli, Yari, Monti, Paola, Bisio, Alessandra, Nguyen, H Thien, Ethayathulla, Abdul S, Ramos, Ana, Foggetti, Giorgia, Menichini, Paola, Menendez, Daniel, Resnick, Michael A, Viadiu, Hector, Fronza, Gilberto, Inga, Alberto

“…Structural and biochemical studies have demonstrated that p73, p63 and p53 recognize DNA with identical amino acids and similar binding affinity. Here,…”
Get full text

EEC- and ADULT-Associated TP63 Mutations Exhibit Functional Heterogeneity Toward P63 Responsive Sequences by Monti, Paola, Russo, Debora, Bocciardi, Renata, Foggetti, Giorgia, Menichini, Paola, Divizia, Maria T., Lerone, Margherita, Graziano, Claudio, Wischmeijer, Anita, Viadiu, Hector, Ravazzolo, Roberto, Inga, Alberto, Fronza, Gilberto

“…ABSTRACT TP63 germ‐line mutations are responsible for a group of human ectodermal dysplasia syndromes, underlining the key role of P63 in the development of…”
Get full text

Both O4-methylthymine and O4-ethylthymine preferentially form alkyl T.G pairs that do not block in vitro replication in a defined sequence by Dosanjh, M K, Menichini, P, Eritja, R, Singer, B

“…The mutagenic potential of O4-methylthymine (m4T) and O4-ethylthymine (e4T) was determined by a primer extension assay on a 25mer oligonucleotide containing a…”
Get more information

In vitro DNA modification by the ultimate carcinogen of 4-nitroquinoline-1-oxide: influence of superhelicity by Menichini, P, Fronza, G, Tornaletti, S, Galiègue-Zouitina, S, Bailleul, B, Loucheux-Lefebvre, M H, Abbondandolo, A, Pedrini, A M

“…The effect of DNA tertiary structure on in vitro modification by 4-acetoxy-aminoquinoline-1-oxide (Ac-4-HAQO) was investigated. The reactivity of pAT153…”
Get more information

Somatic gene mutations in humans by Menichini, P, Abbondandolo, A

Get more information

Characterization of the p53 mutants ability to inhibit p73β transactivation using a yeast-based functional assay by MONTI, Paola, CAMPOMENOSI, Paola, CIRIBILLI, Yari, IANNONE, Raffaella, APRILE, Anna, INGA, Alberto, TADA, Mitsuhiro, MENICHINI, Paola, ABBONDANDOLO, Angelo, FRONZA, Gilberto

“…p53 is the most frequently altered tumor suppressor gene in a wide spectrum of human tumors. The large majority of p53 mutations observed in tumors are…”
Get full text

Preferential loss of chromosomes containing amplified DNA regions in cultured cells by Bonatti, S, Miele, M, Menichini, P, Ottaggio, L, Abbondandolo, A

Get more information

Perturbation of DNA tertiary structure by physical and chemical carcinogens: effects on DNA repair processes by Pedrini, A M, Tornaletti, S, Barabino, S, Menichini, P, Fronza, G, Abbondandolo, A

“…DNA within the cell is organized into higher-order structures characterized by negative supercoiling. Supercoiling is a property of any DNA molecule lacking…”
Get more information

Rev1 and Pol direct sum influence toxicity and mutagenicity of Me-lex, a sequence selective N3-adenine methylating agent by Monti, P, Ciribilli, Y, Russo, D, Bisio, A, Perfumo, C, Andreotti, V, Menichini, P, Inga, A, Huang, X, Gold, B, Fronza, G

“…The relative toxicity and mutagenicity of Me-lex, which selectively generates 3-methyladenine (3-MeA), is dependent on the nature of the DNA repair background…”
Get full text

Nucleotide Excision Repair Defect Influences Lethality and Mutagenicity Induced by Me-lex, a Sequence-Selective N3-Adenine Methylating Agent in the Absence of Base Excision Repair by Monti, Paola, Iannone, Raffaella, Campomenosi, Paola, Ciribilli, Yari, Varadarajan, Sridhar, Shah, Dharini, Menichini, Paola, Gold, Barry, Fronza, Gilberto

“…Using a yeast shuttle vector system, we have previously reported on the toxicity and mutagenicity of Me-lex,…”
Get full text

Transcriptional properties of feline p53 and its tumour-associated mutants: a yeast-based approach by Cardellino, Umberto, Ciribilli, Yari, Andreotti, Virginia, Modesto, Paola, Menichini, Paola, Fronza, Gilberto, Pellegrino, Claudio, Inga, Alberto

“…Mutations at the tumour suppressor gene TP53 are associated with nearly half of human cancers, but they appear to be rare (∼10%) in feline neoplasms. The…”
Get full text

Corrigendum to “Lack of mutagenicity and clastogenicity of PNAEμ-NLS targeted to a regulatory sequence of the translocated c- myc oncogene in Burkitt's lymphoma” [Mutat. Res. 628 (2007) 129–137] by Boffa, L.C., Menichini, P., Bolognesi, C., Cutrona, G., Roncella, S., Damonte, G.L., Millo, E., Mariani, M.R., Matis, S., Russo, D., Ciliutti, P., Ferrarini, M.

Get full text

Strand-specific mutation spectra in repair-proficient and repair-deficient hamster cells by Menichini, P, Vrieling, H, van Zeeland, A A

“…The mutation spectrum induced by UV light has been determined at the hprt locus for both cultured normal (AA8) and UV-sensitive (UV-5) Chinese hamster ovary…”
Get more information

Pyrimidine dimers induced alteration of DNA tertiary structure evidence for unwinding and shortening by Pedrini, A M, Tornaletti, S, Menichini, P, Abbondandolo, A

Get more information

Enzyme-dependent pausing during in vitro replication of O4-methylthymine in a defined oligonucleotide sequence by Menichini, P, Mroczkowska, M M, Singer, B

“…We had previously reported that an oligonucleotide containing a site-specifically incorporated O4-methylthymine (m4T) was replicated under kinetic conditions…”
Get more information

Influences of Base Excision Repair Defects on the Lethality and Mutagenicity Induced by Me-lex, a Sequence-selective N3-Adenine Methylating Agent by Monti, Paola, Campomenosi, Paola, Ciribilli, Yari, Iannone, Raffaella, Inga, Alberto, Shah, Dharini, Scott, Gina, Burns, Philip A, Menichini, Paola, Abbondandolo, Angelo, Gold, Barry, Fronza, Gilberto

“…Due to its minor groove selectivity, Me-lex preferentially generates N3-methyladenine (3-MeA) adducts in double-stranded DNA. We undertook a genetic approach…”
Get full text