Search Results - "Meng, Yanchun"

Dimer targeting peptide mediated precise and controllable drug delivery by upconversion nanocarriers for breast cancer therapy by Zhang, Kunyu, Wan, Zhong, Jiang, Huabo, Xiao, Xiufeng, Feng, Qian, Meng, Yanchun, Yu, Yongsheng

“…Breast cancer is one of the leading causes of cancer-related deaths in women. Chemotherapy remains one of the main clinical treatments for breast cancer…”
Get full text

MicroRNA-143 targets MAPK3 to regulate the proliferation and bone metastasis of human breast cancer cells by Du, Yiqun, Zhang, Jian, Meng, Yanchun, Huang, Mingzhu, Yan, Wangjun, Wu, Zhiqiang

“…MicroRNAs (miRs) have shown tremendous potential to act as therapeutic targets for cancer treatment. In this context, the present study was designed to…”
Get full text

Enhanced CHOLESTEROL biosynthesis promotes breast cancer metastasis via modulating CCDC25 expression and neutrophil extracellular traps formation by Tang, Qiqi, Liang, Beibei, Zhang, Lisha, Li, Xuhui, Li, Hengyu, Jing, Wei, Jiang, Yingjie, Zhou, Felix, Zhang, Jian, Meng, Yanchun, Yang, Xinhua, Yang, Hao, Huang, Gang, Zhao, Jian

“…Neutrophil extracellular traps (NETs) has been demonstrated to regulate the metastasis of breast cancer. In this study, we showed that de novo cholesterol…”
Get full text

Rh-endostatin combined with chemotherapy in patients with advanced or recurrent mucosal melanoma: retrospective analysis of real-world data by Zhang, Xiaowei, Jin, Feng, Jiang, Shiyu, Cao, Jun, Meng, Yanchun, Xu, Yu, ChunmengWang, Chen, Yong, Yang, Huijuan, Kong, Yunyi, Liu, Xin, Luo, Zhiguo

“…Summary Background. Mucosal melanoma is rare and has distinct clinical and genetic features. Even with advances in targeted and immune therapies, the survival…”
Get full text

Clinical characteristics and treatment outcomes of HER2 mutation and HER2 fusion in 22 patients with advanced breast cancer by Mu, Yuxin, Meng, Yanchun, Du, Yiqun, Liu, Xiaojun, Zhang, Jian

“…Background The clinical characteristics and efficacy of human epidermal growth factor receptor‐2 (HER‐2)‐directed agents against HER2 mutations and HER2…”
Get full text

Phase I study of pucotenlimab (HX008), an anti-PD-1 antibody, for patients with advanced solid tumors by Liu, Rujiao, Li, Wenhua, Meng, Yanchun, Gao, Shuiping, Zhang, Jian, Hu, Xichun

“…Background: Pucotenlimab is a humanized immunoglobulin G4 (IgG4) anti programmed cell death protein 1 (anti-PD-1) monoclonal antibody (mAb) with a S228P hinge…”
Get full text

The fine-tuning of thermosensitive and degradable polymer micelles for enhancing intracellular uptake and drug release in tumors by Li, Wei, Li, Jinfeng, Gao, Jie, Li, Bohua, Xia, Yu, Meng, Yanchun, Yu, Yongsheng, Chen, Huaiwen, Dai, Jianxin, Wang, Hao, Guo, Yajun

“…Abstract Focusing on high temperature and low pH of tumor tissue, we prepared temperature and pH responsive poly(N-isopropylacrylamide- co…”
Get full text

The promotion of siRNA delivery to breast cancer overexpressing epidermal growth factor receptor through anti-EGFR antibody conjugation by immunoliposomes by Gao, Jie, Liu, Wei, Xia, Yu, Li, Wei, Sun, Jing, Chen, Huaiwen, Li, Bohua, Zhang, Dapeng, Qian, Weizhu, Meng, Yanchun, Deng, Li, Wang, Hao, Chen, Jianming, Guo, Yajun

“…Abstract The LPD (liposome-polycation-DNA complex) is an effective nanovector for systemically small interfering RNA (siRNA) delivery which was well…”
Get full text

Dalpiciclib Combined With Pyrotinib and Letrozole in Women With HER2-Positive, Hormone Receptor-Positive Metastatic Breast Cancer (LORDSHIPS): A Phase Ib Study by Zhang, Jian, Meng, Yanchun, Wang, Biyun, Wang, Leiping, Cao, Jun, Tao, Zhonghua, Li, Ting, Yao, Wenqing, Hu, Xichun

“…The LORDSHIPS study aimed to explore the safety and efficacy of a novel fully oral triplet combination of dalpiciclib (a potent cyclin-dependent kinase 4/6…”
Get full text

Discovery of acylguanidine oseltamivir carboxylate derivatives as potent neuraminidase inhibitors by Li, Zhaoliang, Meng, Yanchun, Xu, Shengtao, Shen, Wang, Meng, Zhaoqing, Wang, Zhenzhong, Ding, Gang, Huang, Wenzhe, Xiao, Wei, Xu, Jinyi

“…[Display omitted] In search of novel anti-influenza agents with higher potency, a series of acylguanidine oseltamivir carboxylate analogues were synthesized…”
Get full text

Transit-Oriented Development in China: A Comparative Content Analysis of the Spatial Plans of High-Speed Railway Station Areas by Wang, Biyue, de Jong, Martin, van Bueren, Ellen, Ersoy, Aksel, Meng, Yanchun

“…With rapid high-speed railway (HSR) developments in China, HSR-based transit-oriented development (TOD) has proliferated across the country. Although local…”
Get full text

Phase I study of A166, an antibody‒drug conjugate in advanced HER2-expressing solid tumours by Zhang, Jian, Liu, Rujiao, Gao, Shuiping, Li, Wenhua, Chen, Yang, Meng, Yanchun, Liu, Chang, Jin, Wenyue, Wu, Junyan, Wang, Ying, Hao, Yanrong, Yi, Shuli, Qing, Yan, Ge, Junyou, Hu, Xichun

“…In this phase I study, the safety, pharmacokinetics, and antitumour activity of the HER2-targeted antibody–drug conjugate A166 were evaluated in patients with…”
Get full text

Bispecific Antibody to ErbB2 Overcomes Trastuzumab Resistance through Comprehensive Blockade of ErbB2 Heterodimerization by Li, Bohua, Meng, Yanchun, Zheng, Lei, Zhang, Xunmin, Tong, Qing, Tan, Wenlong, Hu, Shi, Li, Hui, Chen, Yang, Song, Jinjing, Zhang, Ge, Zhao, Lei, Zhang, Dapeng, Hou, Sheng, Qian, Weizhu, Guo, Yajun

“…The anti-ErbB2 antibody trastuzumab has shown significant clinical benefits in metastatic breast cancer. However, resistance to trastuzumab is common…”
Get full text

Molecular architecture of the ErbB2 extracellular domain homodimer by Hu, Shi, Sun, Yuna, Meng, Yanchun, Wang, Xiaoze, Yang, Weili, Fu, Wenyan, Guo, Huaizu, Qian, Weizhu, Hou, Sheng, Li, Bohua, Rao, Zihe, Lou, Zhiyong, Guo, Yajun

“…Human epidermal growth factor receptors (HERs or ErbBs) play crucial roles in numerous cellular processes. ErbB2 is a key member of ErbB family, and its…”
Get full text

First-in-human study of DP303c, a HER2-targeted antibody-drug conjugate in patients with HER2 positive solid tumors by Zhang, Jian, Du, Yiqun, Meng, Yanchun, Liu, Xiaojun, Mu, Yuxin, Liu, Yunpeng, Shi, Yehui, Wang, Jufeng, Zang, Aimin, Gu, Shanzhi, Liu, Tianshu, Zhou, Huan, Guo, Hongqian, Xiang, Silong, Zhang, Xialu, Wu, Suqiong, Qi, Huanhuan, Li, Mengke, Hu, Xichun

“…DP303c is a HER2-targeted ADC with a cleavable linker-MMAE payload. Previous in vitro studies demonstrated that DP303c showed similar or better antitumor…”
Get full text

A bispecific anti-ErbB2 antibody potently induces ErbB2 internalization and suppresses ErbB2-overexpressing tumor growth by Zhang, Yajun, Wang, Lingfei, Chong, Xiaodan, Yu, Xiaojie, Meng, Yanchun, Dong, Jian, Wang, Chao, Wang, Huajing, Yang, Yang, Xia, Tian, Zhao, Jian, Li, Bohua

“…The anti-ErbB2 humanized antibody trastuzumab was approved for ErbB2-positive metastatic gastric and gastro-esophageal junction cancer in 2010. Despite the…”
Get full text

The ErbB2-targeting antibody trastuzumab and the small-molecule SRC inhibitor saracatinib synergistically inhibit ErbB2-overexpressing gastric cancer by Han, Siqi, Meng, Yanchun, Tong, Qing, Li, Guangchao, Zhang, Xunmin, Chen, Yalin, Hu, Shi, Zheng, Lei, Tan, Wenlong, Li, Hui, Chen, Yang, Zhang, Ge, Li, Bohua, Guo, Yajun

“…The anti-ErbB2 antibody trastuzumab has shown significant clinical benefits in ErbB2-overexpressing breast and gastric cancer, but resistance to the drug is…”
Get full text

Research on the hierarchical structure of the metropolitan system and economic development of the provincial capital urban circle in Shandong by Qiao, Xiaoyong, Meng, Yanchun, Zhu, Xiangyu

“…Regional development is the trend for future urbanization,and the urban circle is a highly efficient economic spatial pattern of regional development.This…”
Get full text

Efficacy and safety of inetetamab-containing regimens in patients with HER2-positive metastatic breast cancer in first-line/second-line setting by Mu, Yuxin, Meng, Yanchun, Zhang, Jian

“…e13013 Background: Inetetamab is a novel recombinant humanized anti-human epidermal growth factor receptor-2 (HER-2) monoclonal antibody. This real-world…”
Get full text

GW29-e0394 Clinical Value of NSTE-ACS Left Ventricular Myocardial Ischemia Was Evaluated By Layer-specific Strain Technique by Wang, Qin, Meng, Yanchun

Get full text