Search Results - "Meng, Wanli"

Evaluating the clinical efficacy of a long-read sequencing-based approach for carrier screening of spinal muscular atrophy by Long, Ju, Cui, Di, Yu, Chunhui, Meng, Wanli

“…Spinal muscular atrophy (SMA) is the second most common fatal genetic disease in infancy. It is caused by deletion or intragenic pathogenic variants of the…”
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Knocking out Analysis of the CpxP gene using Crispr/Cas9 in Escherichia coli MG1655 by He, Xiaoliang, Ren, Yuwen, Meng, Wanli, Yu, Xinran, Zhou, Xiaohui

“…Based on the analysis of cpxP genes among Escherichia coli strains, cpxP gene-targeting short guide RNA (sgRNA) was designed and inserted into the…”
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Case report: Long-read sequencing identified a novel 14.9-kb deletion of the α-globin gene locus in a family with α-thalassemia in China by Yuan, Yan, Zhou, Xia, Deng, Jing, Zhu, Qun, Peng, Zanping, Chen, Liya, Zou, Ya, Mao, Aiping, Meng, Wanli, Ma, Minhui, Wu, Hongliang

“…: Thalassemia is a hereditary blood disease resulting from globin chain synthesis impairment because of α- and/or β-globin gene variants. α-thalassemia is…”
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Comprehensive Analysis of Fragile X Syndrome: Full Characterization of the FMR1 Locus by Long-Read Sequencing by Liang, Qiaowei, Liu, Yingdi, Liu, Yaning, Duan, Ranhui, Meng, Wanli, Zhan, Jiahan, Xia, Jiahui, Mao, Aiping, Liang, Desheng, Wu, Lingqian

“…Fragile X syndrome (FXS) is the most frequent cause of inherited X-linked intellectual disability. Conventional FXS genetic testing methods mainly focus on…”
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Evaluating the clinical utility of a long-read sequencing-based approach in genetic testing of fragile-X syndrome by Hou, Fei, Mao, Aiping, Shan, Shan, Li, Yan, Meng, Wanli, Zhan, Jiahan, Nie, Wenying, Jin, Hua

“…•Long-read sequencing-based methods were developed to analyze FMR1 genetic variations.•CAFXS successfully called all the FMR1 CGG expansion.•CAFXS identified…”
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Molecular characterization of a novel 83.9-kb deletion of the α-globin upstream regulatory elements by long-read sequencing by Feng, Jianjiang, Mao, Aiping, Lu, Ye, Shi, Haihong, Meng, Wanli, Liang, Chen

“…Inherited deletions of upstream regulatory elements of α-globin genes give rise to α-thalassemia, which is an autosomal recessive monogenic disease. However,…”
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A high-fidelity long-read sequencing-based approach enables accurate and effective genetic diagnosis of spinal muscular atrophy by Bai, Jinli, Qu, Yujin, Huang, Wenchen, Meng, Wanli, Zhan, Jiahan, Wang, Hong, Hou, Wenqi, Jin, Yuwei, Mao, Aiping, Song, Fang

“…•We developed a LRS-based approach to identify all SMN variants in one step.•LRS achieved 100% and 99.5% accuracy for SMN1 and SMN2 copy number,…”
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The comprehensive analysis of thalassemia alleles (CATSA) based on single-molecule real-time technology (SMRT) is a more powerful strategy in the diagnosis of thalassemia caused by rare variants by Feng, Jianjiang, Cui, Di, Li, Caipeng, Yang, Yingsong, Li, Qiuli, Li, Xiaomin, Tan, Shuming, Li, Zhiming, Meng, Wanli, Li, Haoxian, Zhang, Yanghui

“…•Routine genetic analysis of thalassemia only identified 23 common variants in China.•Long-read sequencing identified rare and novel variants that explained…”
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On-line distribution of coordinated attack targets for multi-anti-ship missiles based on genetic simulated annealing algorithm by Suyun, Liu, Wenhua, Ruan, Likuan, Qiu, Wanli, Meng, Xiaotian, Qin, Chuanliang, Shu

“…In the case of coordinated combat, Multi-Missiles Cooperative Targets Assignment(MMCTA)of anti-ship missiles attack aircraft carrier fleet, comprehensively…”
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Dynamically tunable high‐efficiency broadband terahertz linear polarization converter based on Dirac semimetal metamaterials by Meng, Wanli, Hou, Baoyu, Cao, Qiuhong, Lin, Hongmei, Zhou, Wei, Li, Zhaoxin, Li, Dehua

“…An electrically‐tunable polarization converter with a dynamic range of 2.026 to 2.481 THz is designed and simulated in this work. A dumbbell‐like Dirac…”
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Identification of a novel 10.3 kb deletion causing α0-thalassemia by third-generation sequencing: Pedigree analysis and genetic diagnosis by Xu, Runhong, Li, Hui, Yi, Song, Du, Jun, Jin, Jianguo, Qin, Yayun, Jiang, Yufei, Gao, Tangxinzi, Zhang, Chengcheng, Yi, Meiqi, Liu, Yinyin, Meng, Wanli, Li, Jiaqi, Song, Jieping

“…•A novel α-thalassemia 10.3 kb deletion (NC_000016.10:g.172342-182690del) was identified by the third-generation sequencing for the first time. All of these…”
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Identification of a novel 10.3 kb deletion causing α 0 -thalassemia by third-generation sequencing: Pedigree analysis and genetic diagnosis by Xu, Runhong, Li, Hui, Yi, Song, Du, Jun, Jin, Jianguo, Qin, Yayun, Jiang, Yufei, Gao, Tangxinzi, Zhang, Chengcheng, Yi, Meiqi, Liu, Yinyin, Meng, Wanli, Li, Jiaqi, Song, Jieping

“…α-thalassemia is an inherited blood disorder caused by variants in the α-globin gene cluster. Identification of the pathogenic α-globin gene variants is…”
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Cloning and expression of phosphoenolpyruvate carboxykinase from Escherichia coli by Xiaoliang HE, Zhu2 LI, Liqiang2 LIANG, Wanli MENG, Lantian MIAO, Yaozu SUN, Hongguang2 CAI

“…In order to better study the structure and function of phosphoenolpyruvate carboxylase, the phosphoenolpyruvate carboxylase gene is cloned and expressed by PCR…”
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Case report: Long-read sequencing identified a novel 14.9-kb deletion of the α-globin gene locus in a family with α-thalassemia in China by Yuan, Yan, Zhou, Xia, Deng, Jing, Zhu, Qun, Peng, Zanping, Chen, Liya, Zou, Ya, Mao, Aiping, Meng, Wanli, Ma, Minhui, Wu, Hongliang

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七星农场农产品品牌推广策略与营销模式研究 by 秦涛 万莉 曲梦茜

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脑白质高信号与孤立大脑中动脉重度狭窄或闭塞患者临床预后的相关性研究 Association of White Matter Hyperintensities with Clinical Outcome in Patients with Isolated Middle Cerebral Artery Severe Stenosis or Occlusion by 豆朋宇，班梦苛，贵永堃，包万利，张平

“…目的 探讨脑白质高信号（white matter hyperintensity，WMH）与孤立大脑中动脉（middle cerebral artery，MCA）重度狭窄或闭塞患者临床预后的关系。 方法 前瞻性连续纳入就诊于新乡医学院第一附属医院神经内科，发病在72 h内的孤立MCA…”
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