Search Results - "Meng, Quanxin"

Mutagenicity of stereochemical configurations of 1,2-epoxybutene and 1,2:3,4-diepoxybutane in human lymphblastoid cells by Meng, Quanxin, Redetzke, Diana L., Hackfeld, Linda C., Hodge, Richard P., Walker, Dale M., Walker, Vernon E.

“…The carcinogenicity of 1,3-butadiene (BD) is related to its bioactivation to several DNA-reactive metabolites; accumulating evidence suggests that the…”
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Zidovudine-Didanosine Coexposure Potentiates DNA Incorporation of Zidovudine and Mutagenesis in Human Cells by Meng, Quanxin, Walker, Dale M., Olivero, Ofelia A., Shi, Xiaochu, Antiochos, Brendan B., Poirier, Miriam C., Walker, Vernon E.

“…Drug combinations that include nucleoside reverse transcriptase inhibitors (NRTIs) are remarkably effective in preventing maternal-viral transmission of HIV…”
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Integrating murine gene expression studies to understand obstructive lung disease due to chronic inhaled endotoxin by Lai, Peggy S, Hofmann, Oliver, Baron, Rebecca M, Cernadas, Manuela, Meng, Quanxin Ryan, Bresler, Herbert S, Brass, David M, Yang, Ivana V, Schwartz, David A, Christiani, David C, Hide, Winston

“…Endotoxin is a near ubiquitous environmental exposure that that has been associated with both asthma and chronic obstructive pulmonary disease (COPD). These…”
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Relationships between DNA Incorporation, Mutant Frequency, and Loss of Heterozygosity at the TK Locus in Human Lymphoblastoid Cells Exposed to 3′-Azido-3′-deoxythymidine by Meng, Quanxin, Su, Ting, Olivero, Ofelia A., Poirier, Miriam C., Shi, Xiaochu, Ding, Xinxin, Walker, Vernon E.

“…3′-Azido-3′-deoxythymidine (AZT), a thymidine analogue widely used in the treatment of AIDS patients and for prevention of the onset of AIDS in…”
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Characterization of Hprt mutations in cDNA and genomic DNA of T-cell mutants from control and 1,3-butadiene-exposed male B6C3F1 mice and F344 rats by Meng, Quanxin, Walker, Dale M., Scott, Bobby R., Seilkop, Steve K., Aden, James K., Walker, Vernon E.

“…A multiplex PCR procedure for analysis of genomic DNA mutations in the mouse hypoxanthine‐guanine phosphoribosyltransferase (Hprt) gene was developed and then…”
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Comparison of the mutagenic potency of 1,3-butadiene at the hprt locus of T-lymphocytes following inhalation exposure of female B6C3F1 mice and F344 rats by QUANXIN MENG, RECIO, L, REILLY, A. A, WONG, B. A, BAUER, M, WALKER, V. E

“…1,3-Butadiene (BD) is an indirect alkylating agent that has greater cancer potency in the mouse than in the rat. The purpose of the present study was to…”
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Persistence of N7-(2,3,4-Trihydroxybutyl)guanine Adducts in the Livers of Mice and Rats Exposed to 1,3-Butadiene by Oe, Tomoyuki, Kambouris, Sara J, Walker, Vernon E, Meng, Quanxin, Recio, Leslie, Wherli, Suzanne, Chaudhary, Ajai K, Blair, Ian A

“…Liquid chromatography (LC) in combination with tandem mass spectrometry (MS/MS) and stable isotope methodology was employed for the analysis of the N7-guanine…”
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Comparison of the mutations at Hprt exon 3 of T-lymphocytes from B6C3F1 mice and F344 rats exposed by inhalation to 1,3-butadiene or the racemic mixture of 1,2:3,4-diepoxybutane by Meng, Quanxin, Singh, Navjot, Heflich, Robert H, Bauer, Michael J, Walker, Vernon E

“…Experiments were conducted to define the spectra of mutations occurring in Hprt exon 3 of T-cells isolated from spleens of female B6C3F1 mice and F344 rats…”
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Mutagenicity and loss of heterozygosity at the APRT locus in human lymphoblastoid cells exposed to 3′-azido-3′-deoxythymidine by Meng, Quanxin, Grosovsky, Andrew J., Shi, Xiaochu, Walker, Vernon E.

“…Previous experiments in our research group showed that 3′-azido-3′-deoxythymidine (AZT) caused increased mutant frequencies (Mfs) at the X-linked…”
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Culture and propagation of Hprt mutant T-lymphocytes isolated from mouse spleen by Meng, Quanxin, Skopek, Thomas R., Walker, Dale M., Hurley-Leslie, Shellene, Chen, Tao, Zimmer, David M., Walker, Vernon E.

“…The optimization of the mouse lymphocyte Hprt mutation assay has been impeded by the relatively poor growth potential of mouse T‐cells in vitro, which leads to…”
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Cytotoxicity and Gene Expression Profiles in Cell Cultures Exposed to Whole Smoke from Three Types of Cigarettes by Lu, Binbin, Kerepesi, Laura, Wisse, Lynne, Hitchman, Keith, Meng, Quanxin Ryan

“…The purpose of this study was to evaluate and compare the cytotoxicity and gene expression profiles in cell cultures exposed to whole smoke generated from a…”
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Genotoxicity assessed by the comet and GPA assays following in vitro exposure of human lymphoblastoid cells (H9) or perinatal exposure of mother-child pairs to AZT or AZT-3TC by Escobar, Patricia A., Olivero, Ofelia A., Wade, Nancy A., Abrams, Elaine J., Nesel, Carol J., Ness, Roberta B., Day, Richard D., Day, Billy W., Meng, Quanxin, O'Neill, J. Patrick, Walker, Dale M., Poirier, Miriam C., Walker, Vernon E., Bigbee, William L.

“…The genotoxicity of zidovudine (AZT) based treatments was investigated in human H9 lymphoblastoid cells in an in vitro study and in red blood cells (RBCs) from…”
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Fusion protein of single-chain variable domain fragments for treatment of myasthenia gravis by Li, Fangfang, Meng, Fanping, Jin, Quanxin, Sun, Changyuan, Li, Yingxin, Li, Honghua, Jin, Songzhu

“…Single-chain variable domain fragment （scFv） 637 is an antigen-specific scFv of myasthenia gravis. In this study, scFv and human serum albumin genes were…”
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Genotoxicity of 3'-azido-3'-deoxythymidine in the human lymphoblastoid cell line, TK6: relationships between DNA incorporation, mutant frequency, and spectrum of deletion mutations in HPRT by Sussman, H E, Olivero, O A, Meng, Q, Pietras, S M, Poirier, M C, O'Neill, J P, Finette, B A, Bauer, M J, Walker, V E

“…Perinatal treatment with 3'-azido-3'-deoxythymidine (AZT) has been found to reduce the rate of maternal-infant transmission of HIV; however, AZT is genotoxic…”
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Integrating Murine Gene Expression Studies to Understand Obstructive Lung Disease Due to Chronic Inhaled Endotoxin. e62910 by Lai, Peggy S, Hofmann, Oliver, Baron, Rebecca M, Cernadas, Manuela, Meng, Quanxin Ryan, Bresler, Herbert S, Brass, David M, Yang, Ivana V, Schwartz, David A, Christiani, David C

“…Rationale Endotoxin is a near ubiquitous environmental exposure that that has been associated with both asthma and chronic obstructive pulmonary disease…”
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Plasma and cellular markers of 3′-azido-3′-dideoxythymidine (AZT) metabolism as indicators of DNA damage in cord blood mononuclear cells from infants receiving prepartum NRTIs by Meng, Quanxin, Olivero, Ofelia A., Fasco, Michael J., Bellisario, Ronald, Kaminsky, Laurence, Pass, Ken A., Wade, Nancy A., Abrams, Elaine J., Nesel, Carol J., Ness, Roberta B., Bigbee, William L., O'Neill, J. Patrick, Walker, Dale M., Poirier, Miriam C., Walker, Vernon E.

“…Several systemic and cellular markers of 3′‐azido‐3′‐dideoxythymidine (AZT) metabolism and AZT incorporation into nuclear DNA were measured in cord blood from…”
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Age-, gender-, and species-dependent mutagenicity in T cells of mice and rats exposed by inhalation to 1,3-butadiene by Meng, Quanxin, Walker, Dale M., McDonald, Jake D., Henderson, Rogene F., Carter, Meghan M., Cook, Dennis L., Jr, McCash, Consuelo L., Torres, Salina M., Bauer, Michael J., Seilkop, Steven K., Upton, Patricia B., Georgieva, Nadia I., Boysen, Gunnar, Swenberg, James A., Walker, Vernon E.

“…Experiments were performed: (i) to investigate potential age- and gender-dependent differences in mutagenic responses in T cells following exposures of B6C3F1…”
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Mutagenicity of 1,3-butadiene at the Hprt locus of T-lymphocytes following inhalation exposures of female mice and rats by Meng, Q, Henderson, R F, Chen, T, Heflich, R H, Walker, D M, Bauer, M J, Reilly, A A, Walker, V E

“…The species specific response to 1,3-butadiene (BD), an important industrial chemical, was investigated by determining the influence of exposure duration and…”
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Mutagenicity of the racemic mixtures of butadiene monoepoxide and butadiene diepoxide at the Hprt locus of T-lymphocytes following inhalation exposures of female mice and rats by Meng, Q, Henderson, R F, Walker, D M, Bauer, M J, Reilly, A A, Walker, V E

“…The purpose of this study was to determine if Hprt mutant frequency (Mf) data from rodents exposed directly to individual epoxy metabolites of 1,3-butadiene…”
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Genotoxicity of 1,3-butadiene and its epoxy intermediates by Walker, Vernon E, Walker, Dale M, Meng, Quanxin, McDonald, Jacob D, Scott, Bobby R, Seilkop, Steven K, Claffey, David J, Upton, Patricia B, Powley, Mark W, Swenberg, James A, Henderson, Rogene F

“…Current risk assessments of 1,3-butadiene (BD*) are complicated by limited evidence of its carcinogenicity in humans. Hence, there is a critical need to…”
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