Search Results - "Meng, Jianzhou"

Evaluation of a novel inhibitor of aspartate semialdehyde dehydrogenase as a potent antitubercular agent against Mycobacterium tuberculosis by Yang, Ruifang, Cao, Wenli, Liu, Shengsheng, Li, Qiao, Sun, Yong, Liang, Chen, Ren, Weicong, Liu, Yi, Meng, Jianzhou, Li, Chuanyou

“…The in vitro activity of IMB-XMA0038, a novel inhibitor targeting Mycobacterial tuberculosis ( Mtb ) aspartate semialdehyde dehydrogenase, was evaluated…”
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Digging Deeper to Save the Old Anti-tuberculosis Target: D-Alanine-D-Alanine Ligase With a Novel Inhibitor, IMB-0283 by Meng, Jianzhou, Gao, Peng, Wang, Xiao, Guan, Yan, Liu, Yishuang, Xiao, Chunling

“…The emergence of drug-resistant (Mtb) has hampered treatments for tuberculosis, which consequently now require novel agents to overcome such drug resistance…”
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IMB-XMA0038, a new inhibitor targeting aspartate-semialdehyde dehydrogenase of Mycobacterium tuberculosis by Wang, Xiao, Yang, Ruifang, Liu, Sihan, Guan, Yan, Xiao, Chunling, Li, Chuanyou, Meng, Jianzhou, Pang, Yu, Liu, Yishuang

“…The emergence of drug-resistant tuberculosis (TB) constitutes a major challenge to TB control programmes. There is an urgent need to develop effective anti-TB…”
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Identification and Validation of Aspartic Acid Semialdehyde Dehydrogenase as a New Anti-Mycobacterium Tuberculosis Target by Meng, Jianzhou, Yang, Yanhui, Xiao, Chunling, Guan, Yan, Hao, Xueqin, Deng, Qi, Lu, Zhongyang

“…Aspartic acid semialdehyde dehydrogenase (ASADH) lies at the first branch point in the essential aspartic acid biosynthetic pathway that is found in bacteria…”
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Plasmid to generate Mycobacteria mutants by Deng, Qi, Meng, Jianzhou, Guan, Yan, Liu, Yishuang, Xiao, Chunling

“…The generation of conditional mutants has been an effective approach to studying bacteria and validating drug targets, and mutants of Mycobacteria are no…”
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JIB-04, an inhibitor of Jumonji histone demethylase as a potent antitubercular agent against Mycobacterium tuberculosis by Li, Pei, Huang, Qiwen, Xie, Yanling, Zhu, Zhu, Zhan, Senlin, Meng, Jianzhou, Liu, Han

“…The increasing drug resistance of Mycobacterium tuberculosis (Mtb), coupled with the limited availability of effective anti-tuberculosis medications, poses…”
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Long non-coding RNA UCA1 upregulates KIF20A expression to promote cell proliferation and invasion via sponging miR-204 in cervical cancer by He, Qing, Meng, Jianzhou, Liu, Shuai, Zeng, Qiangcheng, Zhu, Qinghua, Wei, Zhenlin, Shao, Yibo

“…Cervical cancer is a female cancer with the second highest motility over the world. It is urgent to find new therapeutic methods based on long-coding RNAs and…”
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Identification of BMVC-8C3O as a novel Pks13 inhibitor with anti-tuberculosis activity by Liu, Tianjun, Meng, Jianzhou, Wang, Bin, Li, Xiaohui, Wang, Qian, Liu, Sihan, Guan, Yan, Wang, Xiao, Liu, Yishuang

“…Given the increasing prevalence of drug-resistant tuberculosis (TB), there is an urgent demand in developing novel anti-TB medications with highly effective,…”
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Design, Synthesis, and Evaluation of the Antitubercular Activity of 5-Phenyl Substituted-5, 6-dihydropyrido[2, 3- d ]pyrimidine-4, 7( 3H , 8H )-dione Compounds by Sun, Lianqi, Kou, Shibo, Wang, Bin, Wang, Yongjian, Meng, Jianzhou, Liu, Tianfu, Ma, Yuanyuan, Zhao, Jianyuan, Yi, Hong, Cen, Shan, Lu, Yu, Li, Zhuorong

“…Tuberculosis (TB) remains a major public health challenge, with research on new anti-TB drugs crucial for global TB elimination efforts. Here, we report a…”
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Design, Synthesis, and Evaluation of the Antitubercular Activity of 5-Phenyl Substituted-5, 6-dihydropyrido2, 3-dpyrimidine-4, 7(3H, 8H)-dione Compounds by Sun, Lianqi, Kou, Shibo, Wang, Bin, Wang, Yongjian, Meng, Jianzhou, Liu, Tianfu, Ma, Yuanyuan, Zhao, Jianyuan, Yi, Hong, Cen, Shan, Lu, Yu, Li, Zhuorong

“…Tuberculosis (TB) remains a major public health challenge, with research on new anti-TB drugs crucial for global TB elimination efforts. Here, we report a…”
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IMB-SD62, a triazolothiadiazoles derivative with promising action against tuberculosis by Deng, Qi, Meng, Jianzhou, Liu, Yishuang, Guan, Yan, Xiao, Chunling

“…One lead 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole was identified as an inhibitor of shikimate dehydrogenase with antitubercular activity…”
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Identification of inhibitors targeting polyketide synthase 13 of Mycobacterium tuberculosis as antituberculosis drug leads by Wang, Xiao, Zhao, Wenting, Wang, Bin, Ding, Wei, Guo, Hao, Zhao, Hongyi, Meng, Jianzhou, Liu, Sihan, Lu, Yu, Liu, Yishuang, Zhang, Dongfeng

“…[Display omitted] •Novel Pks13 inhibitor chemotype was identified.•Compounds 1 and 6e exhibited good activity against TB.•The findings facilitate further TB…”
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Identification of a novel inhibitor of isocitrate lyase as a potent antitubercular agent against both active and non-replicating Mycobacterium tuberculosis by Liu, Yishuang, Zhou, Shuang, Deng, Qi, Li, Xinghua, Meng, Jianzhou, Guan, Yan, Li, Chuanyou, Xiao, Chunling

“…Summary Objective Screen and identify novel inhibitors of isocitrate lyase (ICL) as potent antitubercular agents against Mycobacterium tuberculosis and…”
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Identification and validation of a novel lead compound targeting 4-diphosphocytidyl-2-C-methylerythritol synthetase (IspD) of mycobacteria by Gao, Peng, Yang, Yanhui, Xiao, Chunling, Liu, Yishuang, Gan, Maoluo, Guan, Yan, Hao, Xueqin, Meng, Jianzhou, Zhou, Shuang, Chen, Xiaojuan, Cui, Jiafei

“…Tuberculosis is a serious threat to world-wide public health usually caused in humans by Mycobacterium tuberculosis (M. tuberculosis). It exclusively utilizes…”
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Construction of small plasmid vectors for use in genetic improvement of the extremely acidophilic Acidithiobacillus caldus by Meng, Jianzhou, Wang, Huiyan, Liu, Xiangmei, Lin, Jianqun, Pang, Xin, Lin, Jianqiang

“…The genetic improvement of biomining bacteria including Acidithiobacillus caldus could facilitate the bioleaching process of sulfur-containing minerals…”
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