Search Results - "Meng, Haijin"

Identification of Abcc6 as the Major Causal Gene for Dystrophic Cardiac Calcification in Mice through Integrative Genomics by Meng, Haijin, Vera, Iset, Che, Nam, Wang, Xuping, Wang, Susanna S., Ingram-Drake, Leslie, Schadt, Eric E., Drake, Thomas A., Lusis, Aldons J.

“…The genetic factors contributing to the complex disorder of myocardial calcification are largely unknown. Using a mouse model, we fine-mapped the major locus…”
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Abcc6 Deficiency Causes Increased Infarct Size and Apoptosis in a Mouse Cardiac Ischemia-Reperfusion Model by Mungrue, Imran N, Zhao, Peng, Yao, Yucheng, Meng, Haijin, Rau, Christoph, Havel, Jocelyn V, Gorgels, Theo G.M.F, Bergen, Arthur A.B, MacLellan, W Robb, Drake, Thomas A, Boström, Kristina I, Lusis, Aldons J

“…OBJECTIVE—ABCC6 genetic deficiency underlies pseudoxanthoma elasticum (PXE) in humans, characterized by ectopic calcification, and early cardiac disease. The…”
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Locating a Blood Pressure Quantitative Trait Locus Within 117 kb on the Rat Genome: Substitution Mapping and Renal Expression Analysis by Garrett, Michael R, Meng, Haijin, Rapp, John P, Joe, Bina

“…Previously, a blood pressure (BP) quantitative trait locus (QTL) on rat chromosome 9 (RNO9) was localized to a <2.4 cM interval using congenic strains…”
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A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6J background by Davis, Richard C., Schadt, Eric E., Smith, Desmond J., Hsieh, Elena W.Y., Cervino, Alessandra C.L., van Nas, Atila, Rosales, Melenie, Doss, Sudheer, Meng, Haijin, Allayee, Hooman, Lusis, Aldons J.

“…In the analysis of complex traits, congenic strains are powerful tools because they allow characterization of a single locus in the absence of genetic…”
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PHARMACOKINETICS, SAFETY, AND TOLERABILITY OF ENSIFENTRINE IN HEALTHY CHINESE ADULTS: A PHASE 1, OPEN-LABEL, SINGLE AND MULTIPLE DOSE STUDY by MENG, HAIJIN, LI, XIN, CHEN, CHARLIE, CHENG, CECILIA, ZHANG, PING, ZHANG, CHENCHEN, LI, YUAN

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Localization of a blood pressure QTL to a 2.4-cM interval on rat chromosome 9 using congenic strains by Meng, Haijin, Garrett, Michael R, Dene, Howard, Rapp, John P

“…A blood pressure (BP) quantitative trait locus (QTL) was previously found on rat chromosome 9 using Dahl salt-sensitive (S) and Dahl salt-resistant (R) rats. A…”
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Response by Garrett, Michael R., Rapp, John P., Joe, Bina, Meng, Haijin

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Gls-010, a Novel Anti-PD-1 Mab in Chinese Patients with Relapsed or Refractory Classical Hodgkin Lymphoma: Preliminary Impressive Results of a Phase II Clinical Trial by Song, Yuqin, Zhu, Jun, Lin, Ningjing, Zhang, Mingzhi, Bai, Hai, Liu, Hui, Cui, Jie, Ke, Xiaoyan, Zhang, Huilai, Liu, Lihong, Yan, Dongmei, Jiang, Yongsheng, Zang, Aimin, Qi, Junyuan, Wang, Li, Liu, Zhuogang, Xu, Bing, Zhang, Ying, Zhang, Zhihui, Meng, Haijin

“…Introduction: Classical Hodgkin lymphoma (cHL) is characterized by genetic alterations in 9p24.1, leading to overexpression of PD-L1 ligand. GLS-010 is a novel…”
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Gls-010, a novel anti-PD-1 mAb in Chinese patients with recurrent or metastatic cervical cancer: Results from a multicenter, open-label and single-arm phase II trial by Wu, Xiaohua, Xia, Lingfang, Zhou, Qi, Zhu, Jianqing, Wang, Ke, Chen, Jie, Huang, Yi, Kurb, Gulina, Chang, Baoping, Zhao, Weidong, Wang, Xia, Yang, Yingjie, Lin, Zhongqiu, Luo, Xiaoyong, Lou, Ge, Wang, Chunyan, Wang, Jing, Meng, Haijin

“…Abstract only 6032 Background: GLS-010 is a novel fully human anti-PD-1 mAb. Previous Phase I study exhibited favorable result of tolerance, preliminary…”
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Gls-010, a novel anti-PD-1 mAb in Chinese patients with relapsed or refractory classical Hodgkin lymphoma: Preliminary impressive result of a phase II clinical trial by Song, Yuqin, Zhu, Jun, Lin, Ningjing, Zhang, Mingzhi, Bai, Hai, Liu, Hui, Cui, Jie, Ke, Xiaoyan, Zhang, Huilai, Liu, Lihong, Yan, Dongmei, Jiang, Yongsheng, Zang, Aimin, Qi, Junyuan, Wang, Li, Liu, Zhuogang, Xu, Bing, Zhang, Ying, Zhang, Zhihui, Meng, Haijin

“…Abstract only 8033 Background: classical Hodgkin lymphoma (cHL) are characterized by genetic alterations at the 9p24·1 locus and PD-L1 ligand overexpression…”
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GLS-010, a novel anti-PD-1 mAb in Chinese patients with relapsed or refractory classical Hodgkin’s lymphoma: Preliminary result of a phase II clinical trial by Song, Yuqin, Zhu, Jun, Lin, Ningjing, Zhang, Chen, Zhang, Mingzhi, Bai, Hai, Cui, Jie, Liu, Hui, Ke, Xiaoyan, Jiang, Yongsheng, Zhang, Zhihui, Zhang, Ying, Liu, Lihong, Zang, Aimin, Chen, Chris, Li, Jing, Du, Hong, Meng, Baotong, Xu, Kehui, Meng, Haijin

“…Abstract only e14072 Background: GLS-010 is a novel fully human anti-PD-1 mAb. Previous Phase 1 study exhibited favorable result of tolerance, preliminary…”
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Linkage Analysis and Construction of a Congenic Strain for a Blood Pressure QTL on Rat Chromosome 9 by Rapp, John P., Garrett, Michael R., Dene, Howard, Meng, Haijin, Hoebee, Barbara, Lathrop, G.Mark

“…A blood pressure quantitative trait locus was found (LOD = 5.0) on rat chromosome 9 using a large F2population (N= 233) derived from Dahl salt-sensitive (S)…”
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Gls-010, a novel anti-PD-1 mAb in Chinese advanced gastrointestinal tumor: Result of a phase Ib clinical trial by Lin, Shen, Gong, Jifang, Xu, Yingying, Zhang, Xiaotian, Peng, Zhi, Qi, Changsong, Li, Guochun, Meng, Haijin, Liu, Zhen, Wang, Hui, Chen, Chris, Li, Jing, Zheng, Yong, Lee, Johnathan, Zhang, Yan, Zhang, Qiang, Jin, Ge, Yang, Yining, Zhao, Guodong

“…Abstract only 125 Background: GLS-010 is a novel fully human anti-PD-1 mAb. Phase Ia exhibited good result of tolerance and 240mg fixed dose was selected…”
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Abstract 3275: GLS-010, a novel fully human anti-PD-1 mAb in patients with advanced tumor: Preliminary results of a Phase Ib clinical trial by Shen, Lin, Gong, Jifang, Song, Yuqin, Ye, Dingwei, Lu, Zhihao, Wang, Siyang, Peng, Peijian, Chen, Jianhua, Jiang, Ou, Zhang, Guojun, Bai, Yuxian, Pan, Jianji, Ma, Chunguang, Chen, Li, Ba, Yi, Li, Qi, Lu, Ping, Zhang, Lingli, Yin, Xianli, Gu, Shanzhi, Zhang, Huilai, Su, Hang, Jiang, Yongsheng, Cao, Bangwei, Han, Weiqing, Sun, Yan, Zhang, Feng, Ouyang, Weiwei, Dong, Haiying, Guo, Jianming, Guo, Yabing, Xu, Chongyuan, Qi, Junyuan, Wang, Li, Lv, Jun, Wang, Xiang, Chen, Chris, Li, Jing, Zheng, Yong, Jin, Ge, Yang, Yining, Zhao, Guodong, Yang, Fan, Xu, Kehui, Liang, Xiangying, Pan, Zhaoyang, Meng, Haijin

“…Abstract Background: GLS-010 is a novel fully human anti-PD-1 mAb developed by the OMT transgenic rat platform. In Phase 1a study, GLS-010 exhibited good…”
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Disruption of the Aortic Elastic Lamina and Medial Calcification Share Genetic Determinants in Mice by Wang, Susanna S, Martin, Lisa J, Schadt, Eric E, Meng, Haijin, Wang, Xuping, Zhao, Wei, Ingram-Drake, Leslie, Nebohacova, Martina, Mehrabian, Margarete, Drake, Thomas A, Lusis, Aldons J

“…Disruption of the Aortic Elastic Lamina and Medial Calcification Share Genetic Determinants in Mice Susanna S. Wang, PhD ; Lisa J. Martin, PhD ; Eric E…”
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Are IA-2 and RESP18 Involved in Trait of Blood Pressure? by Cai, Tao

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Are IA-2 and RESP18 Involved in Trait of Blood Pressure?: Response by Garrett, Michael R, Meng, Haijin, Rapp, John P, Joe, Bina

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Localization of a blood pressure quantitative trait locus (QTL) to a 1.7cM interval on rat chromosome 9 by Meng, Haijin

“…An F2 (SxR) population of 233 rats was previously used to conduct a linkage analysis. A blood pressure quantitative trait locus (QTL) was found on rat…”
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Localization of a blood pressure quantitative trait locus (QTL) to a 1.7cM interval on rat chromosome 9 by Meng, Haijin

“…An F2 (SxR) population of 233 rats was previously used to conduct a linkage analysis. A blood pressure quantitative trait locus (QTL) was found on rat…”
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