Search Results - "Menezes, Michelle M."

Preclinical profile of a dopamine D1 potentiator suggests therapeutic utility in neurological and psychiatric disorders by Bruns, Robert F., Mitchell, Stephen N., Wafford, Keith A., Harper, Alex J., Shanks, Elaine A., Carter, Guy, O'Neill, Michael J., Murray, Tracey K., Eastwood, Brian J., Schaus, John M., Beck, James P., Hao, Junliang, Witkin, Jeffrey M., Li, Xia, Chernet, Eyassu, Katner, Jason S., Wang, Hong, Ryder, John W., Masquelin, Meghane E., Thompson, Linda K., Love, Patrick L., Maren, Deanna L., Falcone, Julie F., Menezes, Michelle M., Zhang, Linli, Yang, Charles R., Svensson, Kjell A.

“…DETQ, an allosteric potentiator of the dopamine D1 receptor, was tested in therapeutic models that were known to respond to D1 agonists. Because of a species…”
Get full text

An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis by Svensson, Kjell A, Heinz, Beverly A, Schaus, John M, Beck, James P, Hao, Junliang, Krushinski, Joseph H, Reinhard, Matthew R, Cohen, Michael P, Hellman, Sarah L, Getman, Brian G, Wang, Xushan, Menezes, Michelle M, Maren, Deanna L, Falcone, Julie F, Anderson, Wesley H, Wright, Rebecca A, Morin, S Michelle, Knopp, Kelly L, Adams, Benjamin L, Rogovoy, Borys, Okun, Ilya, Suter, Todd M, Statnick, Michael A, Gehlert, Donald R, Nelson, David L, Lucaites, Virginia L, Emkey, Renee, DeLapp, Neil W, Wiernicki, Todd R, Cramer, Jeffrey W, Yang, Charles R, Bruns, Robert F

“…Allosteric potentiators amplify the sensitivity of physiologic control circuits, a mode of action that could provide therapeutic advantages. This hypothesis…”
Get more information

LSN2424100: a novel, potent orexin-2 receptor antagonist with selectivity over orexin-1 receptors and activity in an animal model predictive of antidepressant-like efficacy by Fitch, Thomas E, Benvenga, Mark J, Jesudason, Cynthia D, Zink, Charity, Vandergriff, Amy B, Menezes, Michelle M, Schober, Douglas A, Rorick-Kehn, Linda M

“…We describe a novel, potent and selective orexin-2 (OX2)/hypocretin-2 receptor antagonist with in vivo activity in an animal model predictive of…”
Get full text

Insulin treatment enhances AT1 receptor function in OK cells by Banday, Anees Ahmad, Siddiqui, Athar H, Menezes, Michelle M, Hussain, Tahir

“…Increased renal sodium retention is considered a major risk factor contributing to hypertension associated with chronic hyperinsulinemia and obesity. However,…”
Get more information

Neurochemical Profile of a Novel Allosteric Potentiator of the Dopamine D1 Receptor by Falcone, Julie F, Mitchell, Stephen N, Carter, Guy, Maren, Deanna L, Katner, Jason, Chernet, Eyassu, Wright, Rebecca A, Wang, Hong, Ryder, John W, Morin, Michelle, Gehlert, Donald R, Johnson, Michael P, Beck, James P, Hao, Junliang, Menezes, Michelle M, Bruns, Robert F, Svensson, Kjell A

“…Abstract only DETQ is a potent and selective dopamine D1 receptor potentiator that is active in several behavioral models (see abstracts by Heinz et al and…”
Get full text

Behavioral Effects of a Novel Allosteric Potentiator of the Dopamine D1 Receptor in Human D1 Knock‐in Mice and Rhesus Monkeys by Svensson, Kjell A, Beck, James P, Hao, Junliang, Schaus, John M, Maren, Deanna L, Menezes, Michelle M, Falcone, Julie F, Anderson, Wesley, Knopp, Kelly, Adams, Benjamin L, Witkin, Jeffrey M, Li, Xia, Cramer, Jeffrey, Harper, Alex J, Wafford, Keith A, Zhang, Linli, Yang, Charles R, Bruns, Robert F

“…Abstract only Allosteric potentiators increase the affinity of endogenousagonist, in effect amplifying physiological control circuits. Because a potentiator…”
Get full text

Rimonabant enhances clozapine‐induced neurochemical and histochemical responses in the rat by Menezes, Michelle M, Davis, Richard J., Johnson, Kandis L., Sundquist, Sarah J., Nomikos, George G., Nisenbaum, Laura K.

“…Acute administration of atypical antipsychotic drugs, such as clozapine, produces an increase in the efflux of catecholamines preferentially in the prefrontal…”
Get full text