Search Results - "Menezes, José C. J. M. D. S"
-
1
Membrane-Associated Ubiquitin Ligase RING Finger Protein 152 Orchestrates Melanogenesis via Tyrosinase Ubiquitination
Published in Membranes (Basel) (01-02-2024)“…Lysosomal degradation of tyrosinase, a pivotal enzyme in melanin synthesis, negatively impacts melanogenesis in melanocytes. Nevertheless, the precise…”
Get full text
Journal Article -
2
Natural and Synthetic Flavonoids: Structure-Activity Relationship and Chemotherapeutic Potential for the Treatment of Leukemia
Published in Critical reviews in food science and nutrition (29-07-2016)“…Flavonoids and their derivatives are polyphenolic secondary metabolites with an extensive spectrum of pharmacological activities, including antioxidants,…”
Get full text
Journal Article -
3
Arylidene indanone scaffold: medicinal chemistry and structure-activity relationship view
Published in RSC advances (01-01-2017)“…Arylidene indanone (AI) scaffolds are considered as the rigid cousins of chalcones, incorporating the α,β-unsaturated ketone system of chalcones forming a…”
Get full text
Journal Article -
4
Long Chain Alkyl Esters of Hydroxycinnamic Acids as Promising Anticancer Agents: Selective Induction of Apoptosis in Cancer Cells
Published in Journal of agricultural and food chemistry (23-08-2017)“…Cancer is the major cause of morbidity and mortality worldwide. Hydroxycinnamic acids (HCAs) are naturally occurring compounds and their alkyl esters may…”
Get full text
Journal Article -
5
Synthesis of New Chlorin e6 Trimethyl and Protoporphyrin IX Dimethyl Ester Derivatives and Their Photophysical and Electrochemical Characterizations
Published in Chemistry : a European journal (13-10-2014)“…In view of increasing demands for efficient photosensitizers for photodynamic therapy (PDT), we herein report the synthesis and photophysical characterizations…”
Get full text
Journal Article -
6
Nitrogen-Based Heterocyclic Compounds: A Promising Class of Antiviral Agents against Chikungunya Virus
Published in Life (Basel, Switzerland) (30-12-2020)“…Arboviruses, in general, are a global threat due to their morbidity and mortality, which results in an important social and economic impact. Chikungunya virus…”
Get full text
Journal Article -
7
Electrospray tandem mass spectrometry analysis of methylenedioxy chalcones, flavanones and flavones
Published in Rapid communications in mass spectrometry (30-06-2013)“…RATIONALE Several methylenedioxy chalcones, flavanones and flavones substituted with mono‐, di‐ and trimethoxy groups have been used in the treatment of…”
Get full text
Journal Article -
8
Inulavosin and its benzo-derivatives, melanogenesis inhibitors, target the copper loading mechanism to the active site of tyrosinase
Published in Pigment cell and melanoma research (01-05-2014)“…Summary Tyrosinase, a melanosomal membrane protein containing copper, is a key enzyme for melanin synthesis in melanocytes. Inulavosin inhibits melanogenesis…”
Get full text
Journal Article -
9
Photodynamic inactivation of bioluminescent Escherichia coli by neutral and cationic pyrrolidine-fused chlorins and isobacteriochlorins
Published in Bioorganic & medicinal chemistry letters (01-02-2014)“…Photodynamic inactivation of bioluminescent Escherichia coli in the presence of cationic chlorin and isobacteriochlorin photosensitizers (PSs) obtained from…”
Get full text
Journal Article -
10
Bioactivity of natural biflavonoids in metabolism-related disease and cancer therapies
Published in Pharmacological research (01-05-2021)“…Natural biflavonoids, such as amentoflavone, bilobetin, ginkgetin, isoginkgetin, taiwaniaflavone, morelloflavone, delicaflavone, hinokiflavone, and other…”
Get full text
Journal Article -
11
Natural biflavonoids as potential therapeutic agents against microbial diseases
Published in The Science of the total environment (15-05-2021)“…Microbes broadly constitute several organisms like viruses, protozoa, bacteria, and fungi present in our biosphere. Fast-paced environmental changes have…”
Get full text
Journal Article -
12
Untangling interactions of a zinc(II) complex containing a coumarin-porphyrin unit with alkaloids in water solutions: a photophysical study
Published in Photochemical & photobiological sciences (01-04-2015)“…A metal complex 1 derivative from a coumarin bearing a porphyrin unit was spectroscopically characterized and its sensing ability towards the alkaloids…”
Get more information
Journal Article -
13
Structural analysis of 2-arylidene-1-indanone derivatives by electrospray ionization tandem mass spectrometry
Published in Rapid communications in mass spectrometry (15-11-2013)“…RATIONALE 2‐arylidene‐4‐methoxy (or hydroxy)‐7‐methyl‐1‐indanone derivatives inspired from donepezil, the current drug used for the treatment of Alzheimer's…”
Get full text
Journal Article -
14
Natural dimers of coumarin, chalcones, and resveratrol and the link between structure and pharmacology
Published in European journal of medicinal chemistry (15-11-2019)“…Natural products like coumarins, chalcones, and resveratrol have inherent biological activity in several models of diseases; therefore, their natural dimeric…”
Get full text
Journal Article -
15
Marine Natural Products in the Battle against Dengue, Zika, and Chikungunya Arboviruses
Published in Journal of the Brazilian Chemical Society (2023)“…Arthropod-borne viruses (arboviruses) are a severe public health problem worldwide, consisting of a significant part of all the emerging infectious diseases…”
Get full text
Journal Article -
16
Methylenedioxy flavonoids: Assessment of cytotoxic and anti-cancer potential in human leukemia cells
Published in European journal of medicinal chemistry (12-09-2014)“…A new series of chalcones, flavanones and flavones with methylenedioxy group at the 3ʹ,4ʹ position in chalcone, 7,8 position in flavanones and flavones with…”
Get full text
Journal Article -
17
Synthesis and antioxidant activity of long chain alkyl hydroxycinnamates
Published in European journal of medicinal chemistry (01-02-2011)“…Long chain alkyl hydroxycinnamates ( 8– 21) were synthesized from the corresponding half esters of malonic acid ( 5– 7) and benzaldehyde derivatives by…”
Get full text
Journal Article -
18
Pyrrolidine-fused chlorin photosensitizer immobilized on solid supports for the photoinactivation of Gram negative bacteria
Published in Dyes and pigments (01-11-2014)“…The emergence of resistant microorganism to conventional therapeutics prompted us to search new and better antimicrobial treatment modalities. In this work was…”
Get full text
Journal Article -
19
Unlocking the Potential of Hydroxycinnamic Acid Bioconjugates: Tailored Derivatives for Biomedical, Cosmetic, and Food Applications
Published in Compounds (10-10-2024)“…This review discusses the development and applications of bioconjugates derived from natural hydroxycinnamic acids (HCA), such as coumaric, sinapic, ferulic,…”
Get full text
Journal Article -
20
Synthesis of porphyrin indolin-2-one conjugates via palladium-catalyzed amination reactions
Published in Tetrahedron (30-09-2012)“…New porphyrin indolin-2-one conjugates were synthesized via palladium-catalyzed amination reactions of iodinated and dibrominated indolin-2-one derivatives…”
Get full text
Journal Article