Adverse Reactions of Proton Pump Inhibitors: A Literature Review

Gastroesophageal Reflux Disease (GRD) is the most common form of esophagitis, where proton pump inhibitors are the most widely used drugs. This study aimed to perform a literature review about the clinical use and adverse reactions of proton pump inhibitors (PPIs). Treatment of GRD evolved in the 19...

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Bibliographic Details
Published in:	Journal of young pharmacists Vol. 13; no. 1; pp. 25 - 27
Main Authors:	Amorim, Dyêggo Carvalho, Travassos, Matheus Pontes Parente, Dias, Igor Torres, Gurgel, Hermano Queiroz, Meneses, Carlos Agusto Oliveira, Teofilo Campos, Fernanda Maria, Azevedo, Arthur Almeida, Furtado Junior, Joao Hildo de Carvalho, Lima Bisneto, Joao Augusto, Nobre Oliveira, Paula Andreia, Amaral Silva, Monica do, Lopes de Oliveira, Guilherme Antonio, Oliveira Chagas, Francineudo, Rodrigues Neto, Edilson Martins
Format:	Journal Article
Language:	English
Published:	Bangalore InPharm 01-01-2021
Subjects:	Drug administration Gastroesophageal reflux Inhibitor drugs Literature reviews Metabolism Side effects
Online Access:	Get full text
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Summary:	Gastroesophageal Reflux Disease (GRD) is the most common form of esophagitis, where proton pump inhibitors are the most widely used drugs. This study aimed to perform a literature review about the clinical use and adverse reactions of proton pump inhibitors (PPIs). Treatment of GRD evolved in the 1970s, when the first PPI, timoprazole, was discovered and in 1979, omeprazole originated, with a high action on the proton bomb. The most potent drugs in gastric suppression are proton pump inhibitors where they act irreversibly in the proton pump H+, K+, - ATPase, the suppression of acid secretion lasts for 24-48 hr. PPIs with prolonged use are associated with changes in the intestinal microbiota, which can be compared to changes seen with antimicrobials, in addition to altering the absorption of iron and Vitamin B12 and the metabolism of calcium and magnesium. The population most susceptible to the appearance of the side effects of PPIs is the elderly, age is a factor that predisposes to the appearance of various pathologies and it is necessary to use many medications thus constituting a polypharmacy, in addition, may increase the risks of drug toxicity due to the hepatic metabolism of the elderly being compromised, this is a worrying condition, as it can cause, in addition to the side effects of PPIs, drug interactions, making pharmacotherapeutic follow-up essential, thus being able to make dose adjustments and assess possible drug-related problems and adverse drug reactions.
ISSN:	0975-1483 0975-1505
DOI:	10.5530/jyp.2021.13.5