Search Results - "Menendez, A"

Fatty acid synthase (FASN) as a therapeutic target in breast cancer by Menendez, Javier A, Lupu, Ruth

“…Ten years ago, we put forward the metabolo-oncogenic nature of fatty acid synthase (FASN) in breast cancer. Since the conception of this hypothesis, which…”
Get more information

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis by Lupu, Ruth, Menendez, Javier A

“…There is a renewed interest in the ultimate role of fatty acid synthase (FASN)--a key lipogenic enzyme catalysing the terminal steps in the de novo biogenesis…”
Get full text

Metformin and SARS-CoV-2: mechanistic lessons on air pollution to weather the cytokine/thrombotic storm in COVID-19 by Menendez, Javier A

“…Pathological signaling in the lung induced by particulate matter (PM) air pollution partially overlaps with that provoked by COVID-19, the pandemic disease…”
Get full text

Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab by Vazquez-Martin, Alejandro, Oliveras-Ferraros, Cristina, Menendez, Javier A

“…Autophagy has been emerging as a novel cytoprotective mechanism to increase tumor cell survival under conditions of metabolic stress and hypoxia as well as to…”
Get full text

Fine-tuning the lipogenic/lipolytic balance to optimize the metabolic requirements of cancer cell growth: Molecular mechanisms and therapeutic perspectives by Menendez, Javier A.

“…Evolving evidence suggest that metabolic requirements for cell proliferation are identical in all normal and cancer cells. HER2 oncogene-overexpressors, a…”
Get full text

Metformin and Breast Cancer: Where Are We Now? by Cejuela, Mónica, Martin-Castillo, Begoña, Menendez, Javier A, Pernas, Sonia

“…Breast cancer is the most prevalent cancer and the leading cause of cancer-related death among women worldwide. Type 2 diabetes-associated metabolic traits…”
Get full text

Potential Drugs Targeting Early Innate Immune Evasion of SARS-Coronavirus 2 via 2'-O-Methylation of Viral RNA by Encinar, José Antonio, Menendez, Javier A

“…The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causing the COVID-19 respiratory disease pandemic utilizes unique 2'-O-methyltransferase…”
Get full text

Microwave heating processes involving carbon materials by Menéndez, J.A., Arenillas, A., Fidalgo, B., Fernández, Y., Zubizarreta, L., Calvo, E.G., Bermúdez, J.M.

“…Carbon materials are, in general, very good absorbents of microwaves, i.e., they are easily heated by microwave radiation. This characteristic allows them to…”
Get full text

Mammosphere formation in breast carcinoma cell lines depends upon expression of E-cadherin by Manuel Iglesias, Juan, Beloqui, Izaskun, Garcia-Garcia, Francisco, Leis, Olatz, Vazquez-Martin, Alejandro, Eguiara, Arrate, Cufi, Silvia, Pavon, Andres, Menendez, Javier A, Dopazo, Joaquin, Martin, Angel G

“…Tumors are heterogeneous at the cellular level where the ability to maintain tumor growth resides in discrete cell populations. Floating sphere-forming assays…”
Get full text

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis by Priego, Neibla, Zhu, Lucía, Monteiro, Cátia, Mulders, Manon, Wasilewski, David, Bindeman, Wendy, Doglio, Laura, Martínez, Liliana, Martínez-Saez, Elena, Ramón y Cajal, Santiago, Megías, Diego, Hernández-Encinas, Elena, Blanco-Aparicio, Carmen, Martínez, Lola, Zarzuela, Eduardo, Muñoz, Javier, Fustero-Torre, Coral, Piñeiro-Yáñez, Elena, Hernández-Laín, Aurelio, Bertero, Luca, Poli, Valeria, Sanchez-Martinez, Melchor, Menendez, Javier A., Soffietti, Riccardo, Bosch-Barrera, Joaquim, Valiente, Manuel

“…The brain microenvironment imposes a particularly intense selective pressure on metastasis-initiating cells, but successful metastases bypass this control…”
Get full text

Metformin as an archetype immuno-metabolic adjuvant for cancer immunotherapy by Verdura, Sara, Cuyàs, Elisabet, Martin-Castillo, Begoña, Menendez, Javier A.

“…The development of a single immuno-metabolic adjuvant capable of modulating, in the appropriate direction and intensity, the complex antagonistic and symbiotic…”
Get full text

Priority-based transformations of stimulus representation in visual working memory by Wan, Quan, Menendez, Jorge A, Postle, Bradley R

“…How does the brain prioritize among the contents of working memory (WM) to appropriately guide behavior? Previous work, employing inverted encoding modeling…”
Get full text

Antibiotic Treatment Alters the Colonic Mucus Layer and Predisposes the Host to Exacerbated Citrobacter rodentium-Induced Colitis by Wlodarska, M, Willing, B, Keeney, K.M, Menendez, A, Bergstrom, K.S, Gill, N, Russell, S.L, Vallance, B.A, Finlay, B.B

“…Antibiotics are often used in the clinic to treat bacterial infections, but the effects of these drugs on microbiota composition and on intestinal immunity are…”
Get full text

Metformin: Sentinel of the Epigenetic Landscapes That Underlie Cell Fate and Identity by Menendez, Javier A

“…The biguanide metformin is the first drug to be tested as a gerotherapeutic in the clinical trial TAME (Targeting Aging with Metformin). The current consensus…”
Get full text

Cell cycle regulation by the nutrient-sensing mammalian target of rapamycin (mTOR) pathway by Cuyàs, Elisabet, Corominas-Faja, Bruna, Joven, Jorge, Menendez, Javier A

“…Cell division involves a series of ordered and controlled events that lead to cell proliferation. Cell cycle progression implies not only demanding amounts of…”
Get more information

The Metaboloepigenetic Dimension of Cancer Stem Cells: Evaluating the Market Potential for New Metabostemness-Targeting Oncology Drugs by Menendez, Javier A

“…The current global portfolio of oncology drugs is unlikely to produce durable disease remission for millions of cancer patients worldwide. This is due, in…”
Get more information

Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities by Joven, Jorge, Camps, Jordi, Luciano-Mateo, Fedra, Menéndez, Javier A., Riera-Borrull, Marta, Rodríguez-Gallego, Esther, Hernández-Aguilera, Anna, Rull, Anna

“…Obesity is not necessarily a predisposing factor for disease. It is the handling of fat and/or excessive energy intake that encompasses the linkage of…”
Get full text

Efficacy of two behavioural management techniques during inferior alveolar nerve block administration in pre-school children: a randomised clinical trial by Leyda-Menéndez, A. M., Vidigal, E. A., Abanto, J., Ribelles-Llop, M.

“…Purpose To evaluate and compare the efficacy of the hands–eyes–mouth distraction technique (HEM-DT) in reducing anxiety and pain levels and improving the…”
Get full text

Structure-Biological Activity Relationships of Extra-Virgin Olive Oil Phenolic Compounds: Health Properties and Bioavailability by Rodríguez-López, Paloma, Lozano-Sanchez, Jesús, Borrás-Linares, Isabel, Emanuelli, Tatiana, Menéndez, Javier A, Segura-Carretero, Antonio

“…Extra-virgin olive oil is regarded as functional food since epidemiological studies and multidisciplinary research have reported convincing evidence that its…”
Get full text

The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells by Vazquez-Martin, Alejandro, Oliveras-Ferraros, Cristina, Menendez, Javier A.

“…Population studies have revealed that treatment with the anti-diabetic drug metformin significantly associates with reduced breast cancer risk.  Animal studies…”
Get full text