Search Results - "Menegazzo, Lisa"

NETosis Delays Diabetic Wound Healing in Mice and Humans by Fadini, Gian Paolo, Menegazzo, Lisa, Rigato, Mauro, Scattolini, Valentina, Poncina, Nicol, Bruttocao, Andrea, Ciciliot, Stefano, Mammano, Fabio, Ciubotaru, Catalin Dacian, Brocco, Enrico, Marescotti, Maria Cristina, Cappellari, Roberta, Arrigoni, Giorgio, Millioni, Renato, Vigili de Kreutzenberg, Saula, Albiero, Mattia, Avogaro, Angelo

“…Upon activation, neutrophils undergo histone citrullination by protein arginine deiminase (PAD)4, exocytosis of chromatin and enzymes as neutrophil…”
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Diabetes-Associated Myelopoiesis Drives Stem Cell Mobilopathy Through an OSM-p66Shc Signaling Pathway by Albiero, Mattia, Ciciliot, Stefano, Tedesco, Serena, Menegazzo, Lisa, D'Anna, Marianna, Scattolini, Valentina, Cappellari, Roberta, Zuccolotto, Gaia, Rosato, Antonio, Cignarella, Andrea, Giorgio, Marco, Avogaro, Angelo, Fadini, Gian Paolo

“…Diabetes impairs the mobilization of hematopoietic stem/progenitor cells (HSPCs) from the bone marrow (BM), which can worsen the outcomes of HSPC…”
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Diabetes Causes Bone Marrow Autonomic Neuropathy and Impairs Stem Cell Mobilization via Dysregulated p66Shc and Sirt1 by ALBIERO, Mattia, PONCINA, Nicol, AVOGARO, Angelo, FADINI, Gian Paolo, TJWA, Marc, CICILIOT, Stefano, MENEGAZZO, Lisa, CEOLOTTO, Giulio, DE KREUTZENBERG, Saula Vigili, MOURA, Rute, GIORGIO, Marco, PELICCI, Piergiuseppe

“…Diabetes compromises the bone marrow (BM) microenvironment and reduces the number of circulating CD34(+) cells. Diabetic autonomic neuropathy (DAN) may impact…”
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Bone Marrow Macrophages Contribute to Diabetic Stem Cell Mobilopathy by Producing Oncostatin M by Albiero, Mattia, Poncina, Nicol, Ciciliot, Stefano, Cappellari, Roberta, Menegazzo, Lisa, Ferraro, Francesca, Bolego, Chiara, Cignarella, Andrea, Avogaro, Angelo, Fadini, Gian Paolo

“…Diabetes affects bone marrow (BM) structure and impairs mobilization of stem cells (SCs) into peripheral blood (PB). This amplifies multiorgan complications…”
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Acute Effects of Linagliptin on Progenitor Cells, Monocyte Phenotypes, and Soluble Mediators in Type 2 Diabetes by Fadini, Gian Paolo, Bonora, Benedetta Maria, Cappellari, Roberta, Menegazzo, Lisa, Vedovato, Monica, Iori, Elisabetta, Marescotti, Maria Cristina, Albiero, Mattia, Avogaro, Angelo

“…Context: Circulating cells, including endothelial progenitor cells (EPCs) and monocyte subtypes, are involved in diabetic complications. Modulation of these…”
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Endothelial progenitor cells in diabetes mellitus by Menegazzo, Lisa, Albiero, Mattia, Avogaro, Angelo, Fadini, Gian Paolo

“…Diabetes mellitus is associated with an increased risk of cardiovascular disease due to its negative impact on the vascular endothelium. The damaged…”
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Widespread Increase in Myeloid Calcifying Cells Contributes to Ectopic Vascular Calcification in Type 2 Diabetes by Fadini, Gian Paolo, Albiero, Mattia, Menegazzo, Lisa, Boscaro, Elisa, Vigili de Kreutzenberg, Saula, Agostini, Carlo, Cabrelle, Anna, Binotto, Gianni, Rattazzi, Marcello, Bertacco, Elisa, Bertorelle, Roberta, Biasini, Lorena, Mion, Monica, Plebani, Mario, Ceolotto, Giulio, Angelini, Annalisa, Castellani, Chiara, Menegolo, Mirko, Grego, Franco, Dimmeler, Stefanie, Seeger, Florian, Zeiher, Andreas, Tiengo, Antonio, Avogaro, Angelo

“…RATIONALE:Acquisition of a procalcific phenotype by resident or circulating cells is important for calcification of atherosclerotic plaques, which is common in…”
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The Redox Enzyme p66Shc Contributes to Diabetes and Ischemia-Induced Delay in Cutaneous Wound Healing by PAOLO FADINI, Gian, ALBIERO, Mattia, AGOSTINI, Carlo, GIUSEPPE PELICCI, Pier, GIORGIO, Marco, AVOGARO, Angelo, MENEGAZZO, Lisa, BOSCARO, Elisa, PAGNIN, Elisa, IORI, Elisabetta, COSMA, Chiara, LAPOLLA, Annunziata, PENGO, Vittorio, STENDARDO, Massimo

“…The redox enzyme p66Shc produces hydrogen peroxide and triggers proapoptotic signals. Genetic deletion of p66Shc prolongs life span and protects against…”
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Effects of Age, Diabetes, and Vascular Disease on Growth Differentiation Factor 11: First-in-Human Study by Fadini, Gian Paolo, Menegazzo, Lisa, Bonora, Benedetta Maria, Mazzucato, Marta, Persano, Sara, Vigili de Kreutzenberg, Saula, Avogaro, Angelo

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Stem cell compartmentalization in diabetes and high cardiovascular risk reveals the role of DPP-4 in diabetic stem cell mobilopathy by Fadini, Gian Paolo, Albiero, Mattia, Seeger, Florian, Poncina, Nicol, Menegazzo, Lisa, Angelini, Annalisa, Castellani, Chiara, Thiene, Gaetano, Agostini, Carlo, Cappellari, Roberta, Boscaro, Elisa, Zeiher, Andreas, Dimmeler, Stefanie, Avogaro, Angelo

“…Bone marrow (BM) derived stem and progenitor cells contribute to cardiovascular homeostasis and are affected by cardiovascular risk factors. We devised a…”
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The dipeptidyl peptidase-4 inhibitor saxagliptin improves function of circulating pro-angiogenic cells from type 2 diabetic patients by Poncina, Nicol, Albiero, Mattia, Menegazzo, Lisa, Cappellari, Roberta, Avogaro, Angelo, Fadini, Gian Paolo

“…Type 2 diabetes (T2D) is associated with reduction and dysfunction of circulating pro-angiogenic cells (PACs). DPP-4 inhibitors, a class of oral agents for…”
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Circulating Smooth Muscle Progenitors and Atherosclerosis by Albiero, Mattia, PhD, Menegazzo, Lisa, BSc, Fadini, Gian Paolo, MD

“…Atherosclerosis is a chronic inflammatory disease of the arterial wall; during the transition from primitive fatty streaks to more complex lesions, smooth…”
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Myeloid calcifying cells promote atherosclerotic calcification via paracrine activity and allograft inflammatory factor-1 overexpression by Albiero, Mattia, Rattazzi, Marcello, Menegazzo, Lisa, Boscaro, Elisa, Cappellari, Roberta, Pagnin, Elisa, Bertacco, Elisa, Poncina, Nicol, Dyar, Kenneth, Ciciliot, Stefano, Iwabuchi, Kazuya, Millioni, Renato, Arrigoni, Giorgio, Kraenkel, Nicolle, Landmesser, Ulf, Agostini, Carlo, Avogaro, Angelo, Fadini, Gian Paolo

“…Several cell types contribute to atherosclerotic calcification. Myeloid calcifying cells (MCCs) are monocytes expressing osteocalcin (OC) and bone alkaline…”
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Rosuvastatin stimulates clonogenic potential and anti-inflammatory properties of endothelial progenitor cells by Fadini, Gian Paolo, Albiero, Mattia, Boscaro, Elisa, Menegazzo, Lisa, Cabrelle, Anna, Piliego, Teodoro, Federici, Massimo, Agostini, Carlo, Avogaro, Angelo

“…EPCs (endothelial progenitor cells) exert vasculoprotective effects and can be used for regenerative therapies. However, several isolation protocols have been…”
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Endothelial dysfunction in diabetes: the role of reparatory mechanisms by Avogaro, Angelo, Albiero, Mattia, Menegazzo, Lisa, de Kreutzenberg, Saula, Fadini, Gian Paolo

“…Vascular injury and tissue ischemia, through the release of growth factors and cytokines, mobilize EPCs, which, once in the peripheral circulation,…”
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Oral Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Increases Circulating Endothelial Progenitor Cells in Patients With Type 2 Diabetes: Possible role of stromal-derived factor-1α by Fadini, Gian Paolo, Boscaro, Elisa, Albiero, Mattia, Menegazzo, Lisa, Frison, Vera, de Kreutzenberg, Saula, Agostini, Carlo, Tiengo, Antonio, Avogaro, Angelo

“…OBJECTIVE: Vasculoprotective endothelial progenitor cells (EPCs) are regulated by stromal-derived factor-1α (SDF-1α) and are reduced in type 2 diabetes…”
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NETosis is induced by high glucose and associated with type 2 diabetes by Menegazzo, Lisa, Ciciliot, Stefano, Poncina, Nicol, Mazzucato, Marta, Persano, Mariasara, Bonora, Benedetta, Albiero, Mattia, Vigili de Kreutzenberg, Saula, Avogaro, Angelo, Fadini, Gian Paolo

“…Aims The role of neutrophils in diabetes and its complications is unclear. Upon challenge with microbes and inflammatory triggers, neutrophils release enzymes…”
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The antidiabetic drug metformin blunts NETosis in vitro and reduces circulating NETosis biomarkers in vivo by Menegazzo, Lisa, Scattolini, Valentina, Cappellari, Roberta, Bonora, Benedetta Maria, Albiero, Mattia, Bortolozzi, Mario, Romanato, Filippo, Ceolotto, Giulio, Vigili de Kreutzeberg, Saula, Avogaro, Angelo, Fadini, Gian Paolo

“…Aims Diabetes is associated with an excess release of neutrophil extracellular traps (NETs) and an enhanced NETosis, a neutrophil cell death programme…”
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Pharmacologic PPAR-γ Activation Reprograms Bone Marrow Macrophages and Partially Rescues HSPC Mobilization in Human and Murine Diabetes by Tedesco, Serena, Ciciliot, Stefano, Menegazzo, Lisa, D'Anna, Marianna, Scattolini, Valentina, Cappellari, Roberta, Cignarella, Andrea, Avogaro, Angelo, Albiero, Mattia, Fadini, Gian Paolo

“…Mobilization of hematopoietic stem/progenitor cells (HSPC) from the bone marrow (BM) is impaired in diabetes. Excess oncostatin M (OSM) produced by M1…”
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Diabetes mellitus impairs circulating proangiogenic granulocytes by Cappellari, Roberta, D’Anna, Marianna, Menegazzo, Lisa, Bonora, Benedetta Maria, Albiero, Mattia, Avogaro, Angelo, Fadini, Gian Paolo

“…Aims/hypothesis Cardiovascular risk in diabetes is at least in part attributable to defective angiogenesis. Since diabetes negatively affects blood cells…”
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