Tolerance of preschoolers to two dosage strengths of vitamin A preparation

The tolerance to two alternative large-dosage strengths of vitamin A preparation was determined in a double-blind study involving 2471 children in two municipalities in the Philippines. Each child, aged 1–6 y, not suffering from active xerophthalmia or from nausea and/or vomiting, headache, diarrhea...

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Bibliographic Details
Published in:	The American journal of clinical nutrition Vol. 52; no. 4; pp. 694 - 700
Main Authors:	Florentino, RF, Tanchoco, CC, Ramos, AC, Mendoza, TS, Natividad, EP, Tangco, JB, Sommer, A
Format:	Journal Article
Language:	English
Published:	Bethesda, MD Elsevier Inc 01-10-1990 American Society for Clinical Nutrition
Subjects:	Aging - physiology Biological and medical sciences Child Child, Preschool Diarrhea - chemically induced Dose-Response Relationship, Drug EFECTOS SECUNDARIOS EFFET SECONDAIRE ENVENENAMIENTO ESSAI Fever - chemically induced FILIPINAS General and cellular metabolism. Vitamins Headache - chemically induced Humans Infant INTOXICATION Medical sciences Nausea - chemically induced Pharmacology. Drug treatments PHILIPPINES PRUEBAS RETINOL SINTOMAS SYMPTOME TOXICIDAD TOXICITE Vitamin A - administration & dosage Vitamin A - adverse effects VITAMINAS VITAMINE Vomiting - chemically induced Human Assay Chemotherapy Treatment Toxicity Vitamin Tolerance Infant Child Comparative study Retinol
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Summary:	The tolerance to two alternative large-dosage strengths of vitamin A preparation was determined in a double-blind study involving 2471 children in two municipalities in the Philippines. Each child, aged 1–6 y, not suffering from active xerophthalmia or from nausea and/or vomiting, headache, diarrhea, and fever, was randomly given 1 mL of a syrupy suspension later identified to contain 0, 60, or 30 mg vitamin A. Clinical evaluation of subjects was done by physicians 24 h and 1 wk after dosing. Nausea and/or vomiting and headache were twice as common among children given 60 mg than those given 30 mg. Severe vomiting (1.2%) was confined to those given 60 mg. Almost all experienced their symptoms within 24 h after dosing; symptoms lasted for no more than 12–24 h. The incidence of diarrhea and fever for vitamin A recipients was not significantly different from that of those receiving placebo.
Bibliography:	S30 9105448
ISSN:	0002-9165 1938-3207
DOI:	10.1093/ajcn/52.4.694