Search Results - "Mendonça Júnior, Francisco J.B."

An electrochemical biosensor based on Hairpin-DNA modified gold electrode for detection of DNA damage by a hybrid cancer drug intercalation by Lozano Untiveros, Katherine, da Silva, Emanuella Gomes, de Abreu, Fabiane Caxico, da Silva-Júnior, Edeildo Ferreira, de Araújo-Junior, João Xavier, Mendoça de Aquino, Thiago, Armas, Stephanie M., de Moura, Ricardo Olímpio, Mendonça-Junior, Francisco J.B., Serafim, Vanessa Lima, Chumbimuni-Torres, Karin

“…An efficient and new electrochemical biosensor for detection of DNA damage, induced by the interaction of the hybrid anti-cancer compound (7ESTAC01) with DNA,…”
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Synthetic thiophenes induce chromosomal damage and trigger apoptosis in human cancer cell lines by Franco, Filipe N., Oliveira, Júlia T., Tecchio, Kimberly B., Santos, Flaviana A., Rêgo, Moacyr J.B.M., Mendonça-Júnior, Francisco J.B., Pitta, Maira G.R., Pereira, Michelly C., Ribeiro, Rosy I.M.A., Santos, Vanessa J.S.V., Santos, Fabio V.

“…Thiophenes are heterocyclic compounds containing a five-membered ring with sulphur as the heteroatom. This class of substances has been shown to have several…”
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Natural Bioactive Products with Antioxidant Properties Useful in Neurodegenerative Diseases by Mendonça-Junior, Francisco J. B., Scotti, Marcus T., Nayarisseri, Anuraj, Zondegoumba, Ernestine N. T., Scotti, Luciana

“…Whereas oxidative stress plays an unquestionable and central role in NDs, the control of free radicals and reactive oxygen species levels represents an…”
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Docking Studies for Multi-Target Drugs by Scotti, Luciana, Mendonca Junior, Francisco J B, Ishiki, Hamilton M, Ribeiro, Frederico F, Singla, Rajeev K, Barbosa Filho, Jose M, Da Silva, Marcelo S, Scotti, Marcus T

“…The most basic principle of drug action is found in the lock and key model, where the highest possible affinity for a target that also avoids side effects is…”
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Docking of Natural Products against Neurodegenerative Diseases: General Concepts by Ribeiro, Frederico F, Mendonca Junior, Francisco J B, Ghasemi, Jahan B, Ishiki, Hamilton M, Scotti, Marcus T, Scotti, Luciana

“…Since antiquity, humanity has used medicinal plant preparations to cure its ills, and, as research has progressed, new technologies have enabled more…”
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Evaluation of Antifungal Activity and Mode of Action of New Coumarin Derivative, 7-Hydroxy-6-nitro-2H-1-benzopyran-2-one, against Aspergillus spp. by Lima, Edeltrudes Oliveira, Mendonça Junior, F. J. B., Pereira, Fillipe de Oliveira, Sousa, Janiere Pereira de, Araújo, Rodrigo Santos Aquino de, Guerra, Felipe Queiroga Sarmento, Barbosa-Filho, José M.

“…Aspergillus spp. produce a wide variety of diseases. For the treatment of such infections, the azoles and Amphotericin B are used in various formulations. The…”
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Correlation between DNA/HSA-interactions and antimalarial activity of acridine derivatives: Proposing a possible mechanism of action by de M. Silva, Marina, Macedo, Taís S., Teixeira, Helena Mariana P., Moreira, Diogo Rodrigo M., Soares, Milena B.P., da C. Pereira, Ana Ligia, de L. Serafim, Vanessa, Mendonça-Júnior, Francisco J.B., do Carmo A. de Lima, Maria, de Moura, Ricardo O., da Silva-Júnior, Edeildo F., de Araújo-Júnior, João Xavier, de A. Dantas, Maria Dayanne, de O. O. Nascimento, Eduarda, Maciel, Thamilla Maria S., de Aquino, Thiago Mendonça, Figueiredo, Isis M., Santos, Josué C.C.

“…Acridines are considered an important class of compounds due to their wide variety of biological activities. In this work, we synthesized four acridine…”
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Evidence for the involvement of descending pain-inhibitory mechanisms in the attenuation of cancer pain by carvacrol aided through a docking study by Guimarães, Adriana G., Scotti, Luciana, Scotti, Marcus Tullius, Mendonça Júnior, Francisco J.B., Melo, Nayara S.R., Alves, Rafael S., De Lucca Júnior, Waldecy, Bezerra, Daniel P., Gelain, Daniel P., Quintans Júnior, Lucindo J.

“…The present study evaluated the carvacrol (CARV) effect on hyperalgesia and nociception induced by sarcoma 180 (S180) in mice. Carvacrol treatment…”
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Thiazine-derived compounds in inhibiting efflux pump in Staphylococcus aureus K2068, mepA gene expression, and membrane permeability alteration by Freitas, Priscilla R., de Araújo, Ana C.J., Araújo, Isaac M., de Almeida, Ray S., Borges, João A.O., Paulo, Cícera L.R., Oliveira-Tintino, Cícera D.M., Miranda, Gustavo M., Araújo-Neto, José B., Nascimento, Igor J.S., Araújo-Júnior, João X., Silva, Julia M.A., Balbino, Tereza C.L., Silva-Júnior, Edeildo F., Aquino, Thiago M., Mendonca-Junior, Francisco J.B., Marinho, Emmanuel S., Santos, Hélcio S., Lima, Clara Mariana Gonçalves, Obaidullah, Ahmad J., Bin Emran, Talha, Cunha, Francisco A.B., Menezes, Irwin R.A., Tintino, Saulo R., Coutinho, Henrique D.M.

“…Staphylococcus aureus is a bacterium responsible for resistance to multiple drugs and the efflux system is widely studied among the resistance mechanisms…”
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Artificial Neural Network Methods Applied to Drug Discovery for Neglected Diseases by Scotti, Luciana, Ishiki, Hamilton, Mendonça Júnior, Francisco J B, da Silva, Marcelo S, Scotti, Marcus T

“…Among the chemometric tools used in rational drug design, we find artificial neural network methods (ANNs), a statistical learning algorithm similar to the…”
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Chemical analysis of Brasilimeria Stach, 1949 (Hexapoda, Collembola, Neanuridae) hemolymphatic secretion, and description of a new species by Zeppelini, Douglas, Queiroz, Gabriel C, Lopes, Norberto P, Mendonça-Junior, Francisco J B

“…Though Collembola is a widespread hexapod its use of chemical compounds for defense has been reported for only a few European species. Chemical composition…”
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Synthesis and Evaluation of 2‐Aminothiophene Derivatives as Staphylococcus aureus Efflux Pump Inhibitors by Cruz, Rayssa M. D., Zelli, Renaud, Benshain, Sarah, Cruz, Ryldene M. D., Siqueira‐Júnior, José P., Décout, Jean‐Luc, Mingeot‐Leclercq, Marie‐Paule, Mendonça‐Junior, Francisco J. B.

“…2‐aminothiophene derivatives (2AT) in which the thiophene ring is fused with a cycloalkyl or a N‐acylated piperidine ring by positions 5 and 6 and carrying a…”
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A new coumarin derivative, 4-acetatecoumarin, with antifungal activity and association study against Aspergillus spp by Guerra, Felipe Q.S., Araújo, Rodrigo S.A., Sousa, Janiere P., Silva, Viviane A., Pereira, Fillipe O., Mendonça-Junior, Francisco J.B., Barbosa-Filho, José M., Pereira, Julio Abrantes, Lima, Edeltrudes O.

“…Fungal infections have become a concern for health professionals, and the emergence of resistant strains has been reported for all known classes of antifungal…”
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Dynamic Simulation, Docking and DFT Studies Applied to a Set of Anti-Acetylcholinesterase Inhibitors in the enzyme β-Secretase (BACE-1): An Important Therapeutic Target in Alzheimer`s disease by Silva-Junior, Edeildo F, Barcellos Franca, Paulo H, Quintans-Junior, Lucindo J, Mendonca-Junior, Francisco J B, Scotti, Luciana, Scotti, Marcus T, de Aquino, Thiago M, de Araujo-Junior, Joao X

“…Alzheimer`s disease (AD) affects mainly elderly people over 60 years of age. Currently, there are more than 35 million people with this disease worldwide. The…”
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Theoretical research into anticancer activity of diterpenes isolated from the paraiban flora by Ishiki, Hamilton, Junior, Francisco J B Mendonça, Santos, Paula F, Tavares, Josean F, Silva, Marcelo S, Scotti, Marcus T

“…Many studies of the scientific literature discuss the anticancer activity of diterpenes inhibiting the Akt/IKK/NF-kappaB pro-survival signaling cascade, mainly…”
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Synthesis and preliminary ex vivo evaluation of the spasmolytic activity of 1,3-thiazolium- and 1,3,4-thiadiazolium-5-methylthio- and 5-thioacetate derivatives by Luis, José A. S., Aquino, Thiago M. De, Lira, Bruno F., Filho, Petrônio F. A., Scotti, Marcus T., Scotti, Luciana, Moura, Ricardo O. De, Junior, Francisco J. B. Mendonça

“…Seven new compounds have been synthetized in satisfactory yields (51-78 %) through the treatment of mesoionic 1,3-thiazolium-5-thiolate (4a-d) and…”
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Dimethyl 2-[(acridin-9-yl)methyl-idene]malonate by de Almeida, Sinara M V, Pitta, Ivan R, de Lima, Maria do Carmo A, Mendonça Junior, Francisco J B, de Simone, Carlos A

“…In the title compound, C(19)H(15)NO(4), the acridine system is essentially planar (r.m.s. deviation = 0.015 Å). The crystal packing exhibits π-π inter-actions…”
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2-(2-Nitroanilino)-4,5,6,7-tetrahydrobenzo[ b ]thiophene-3-carbonitrile by Mendonça Junior, Francisco J.B., Lima, Maria do Carmo A. de, Galdino, Suely L., Pitta, Ivan R., Simone, Carlos A. de

“…The title compound, C15H13N3O2S, was synthesized by the reaction of 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carbonitrile and…”
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2-(2-Nitroanilino)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carbonitrile by Maria do Carmo A. de Lima, Francisco J. B. Mendonça Junior, Suely L. Galdino, Ivan R. Pitta, Carlos A. de Simone

“…The title compound, C16H15N3O2S, was synthesized by the reaction of 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carbonitrile and…”
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Chemometric studies on potential larvicidal compounds against Aedes aegypti by Scotti, Luciana, Scotti, Marcus Tullius, Silva, Viviane Barros, Santos, Sandra Regina Lima, Cavalcanti, Sócrates C H, Mendonça, Jr, Francisco J B

“…The mosquito Aedes aegypti (Diptera, Culicidae) is the vector of yellow and dengue fever. In this study, chemometric tools, such as, Principal Component…”
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