Synthesis and release behavior of layered double hydroxides–carbamazepine composites

Synthesis and release behavior of layered double hydroxides–carbamazepine composites

Carbamazepine (CBZ) was incorporated into layered double hydroxides (LDH) to be used as a controlled drug system in solid tumors. CBZ has a formal charge of zero, so its incorporation in the anionic clay implies a challenge. Aiming to overcome this problem, CBZ was loaded into LDH with sodium cholat...

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Bibliographic Details
Published in:Scientific reports Vol. 11; no. 1; p. 20585
Main Authors: Peralta, Ma. F., Mendieta, S. N., Scolari, I. R., Granero, G. E., Crivello, M. E.
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 18-10-2021
Nature Publishing Group
Nature Portfolio
Subjects:
639/301
639/925
Acetic acid
Carbamazepine
Cytoplasm
Fourier transforms
Humanities and Social Sciences
Hydroxides
Infrared spectroscopy
multidisciplinary
Nanocomposites
NMR
Nuclear magnetic resonance
pH effects
Science
Science (multidisciplinary)
Sodium cholate
Solid tumors
Thermal stability
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Summary:Carbamazepine (CBZ) was incorporated into layered double hydroxides (LDH) to be used as a controlled drug system in solid tumors. CBZ has a formal charge of zero, so its incorporation in the anionic clay implies a challenge. Aiming to overcome this problem, CBZ was loaded into LDH with sodium cholate (SC), a surfactant with negative charge and, for comparison, without SC by the reconstruction method. Surprisingly, it was found that both resultant nanocomposites had similar CBZ encapsulation efficiency, around 75%, and the LDH-CBZ system without SC showed a better performance in relation to the release kinetics of CBZ in simulated body fluid (pH 7.4) and acetate buffer simulating the cellular cytoplasm (pH 4.8) than the system with SC. The CBZ dimensions were measured with Chem3D and, according to the basal spacing obtained from X-ray patterns, it can be arranged in the LDH-CBZ system as a monolayer with the long axis parallel to the LDH layers. Fourier transform infrared spectroscopy and solid state NMR measurements confirmed the presence of the drug, and thermogravimetric analyses showed an enhanced thermal stability for CBZ. These results have interesting implications since they increase the spectrum of LDH application as a controlled drug system to a large number of nonionic drugs, without the addition of other components.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-00117-9