Search Results - "Mendez, Melanie E"

Conditional Deletion of Sost in MSC‐Derived Lineages Identifies Specific Cell‐Type Contributions to Bone Mass and B‐Cell Development by Yee, Cristal S, Manilay, Jennifer O, Chang, Jiun C, Hum, Nicholas R, Murugesh, Deepa K, Bajwa, Jamila, Mendez, Melanie E, Economides, Aris E, Horan, Daniel J, Robling, Alexander G, Loots, Gabriela G

“…ABSTRACT Sclerostin (Sost) is a negative regulator of bone formation and blocking its function via antibodies has shown great therapeutic promise by increasing…”
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Antibiotic Treatment Prior to Injury Improves Post-Traumatic Osteoarthritis Outcomes in Mice by Mendez, Melanie E, Murugesh, Deepa K, Sebastian, Aimy, Hum, Nicholas R, McCloy, Summer A, Kuhn, Edward A, Christiansen, Blaine A, Loots, Gabriela G

“…Osteoarthritis (OA) is a painful and debilitating disease characterized by the chronic and progressive degradation of articular cartilage. Post-traumatic OA…”
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Global Gene Expression Analysis Identifies Age-Related Differences in Knee Joint Transcriptome during the Development of Post-Traumatic Osteoarthritis in Mice by Sebastian, Aimy, Murugesh, Deepa K, Mendez, Melanie E, Hum, Nicholas R, Rios-Arce, Naiomy D, McCool, Jillian L, Christiansen, Blaine A, Loots, Gabriela G

“…Aging and injury are two major risk factors for osteoarthritis (OA). Yet, very little is known about how aging and injury interact and contribute to OA…”
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Comparative Transcriptomics Identifies Novel Genes and Pathways Involved in Post-Traumatic Osteoarthritis Development and Progression by Sebastian, Aimy, Chang, Jiun C, Mendez, Melanie E, Murugesh, Deepa K, Hatsell, Sarah, Economides, Aris N, Christiansen, Blaine A, Loots, Gabriela G

“…Anterior cruciate ligament (ACL) injuries often result in post-traumatic osteoarthritis (PTOA). To better understand the molecular mechanisms behind PTOA…”
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Antibiotic Treatment Prior to Injury Abrogates the Detrimental Effects of LPS in STR/ort Mice Susceptible to Osteoarthritis Development by Mendez, Melanie E, Murugesh, Deepa K, Christiansen, Blaine A, Loots, Gabriela G

“…ABSTRACT Post traumatic osteoarthritis (PTOA) is a form of secondary osteoarthritis (OA) that develops in ~50% of cases of severe articular joint injuries and…”
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LPS‐Induced Inflammation Prior to Injury Exacerbates the Development of Post‐Traumatic Osteoarthritis in Mice by Mendez, Melanie E, Sebastian, Aimy, Murugesh, Deepa K, Hum, Nicholas R, McCool, Jillian L, Hsia, Allison W, Christiansen, Blaine A, Loots, Gabriela G

“…ABSTRACT Osteoarthritis (OA) is a debilitating and painful disease characterized by the progressive loss of articular cartilage. Post‐traumatic osteoarthritis…”
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Manipulation of the Gut Microbiome Alters Acetaminophen Biodisposition in Mice by Malfatti, Michael A., Kuhn, Edward A., Murugesh, Deepa K., Mendez, Melanie E., Hum, Nicholas, Thissen, James B., Jaing, Crystal J., Loots, Gabriela G.

“…The gut microbiota is a vast and diverse microbial community that has co-evolved with its host to perform a variety of essential functions involved in the…”
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LPS-Induced Inflammation Prior to Injury Exacerbates the Development of Post-Traumatic Osteoarthritis in Mice by Mendez, Melanie E., Sebastian, Aimy, Murugesh, Deepa K., Hum, Nicholas R., McCool, Jillian L., Hsia, Allison W., Christiansen, Blaine A., Loots, Gabriela G.

“…Osteoarthritis (OA) is a debilitating and painful disease characterized by the progressive loss of articular cartilage. Post-traumatic osteoarthritis (PTOA) is…”
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Post-traumatic osteoarthritis progression is diminished by early mechanical unloading and anti-inflammatory treatment in mice by Hsia, A.W., Jbeily, E.H., Mendez, M.E., Cunningham, H.C., Biris, K.K., Bang, H., Lee, C.A., Loots, G.G., Christiansen, B.A.

“…Post-traumatic osteoarthritis (PTOA) is a degenerative joint disease initiated by injury. Early phase (0–7 days) treatments often include rest (unloading) and…”
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Manipulation of the Gut Microbiome Alters Acetaminophen Biodisposition in Mice by Malfatti, Michael A., Kuhn, Edward A., Murugesh, Deepa K., Mendez, Melanie E., Hum, Nicholas, Thissen, James B., Jaing, Crystal J., Loots, Gabriela G.

“…The gut microbiota is a vast and diverse microbial community that has co-evolved with its host to perform a variety of essential functions involved in the…”
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Conditional Deletion of Sost in MSC-Derived Lineages Identifies Specific Cell-Type Contributions to Bone Mass and B-Cell Development: DELETION OF Sost IN MSC-DERIVED LINEAGES by Yee, Cristal S., Manilay, Jennifer O., Chang, Jiun C., Hum, Nicholas R., Murugesh, Deepa K., Bajwa, Jamila, Mendez, Melanie E., Economides, Aris E., Horan, Daniel J., Robling, Alexander G., Loots, Gabriela G.

“…Sclerostin (Sost) is a negative regulator of bone formation and blocking its function via antibodies has shown great therapeutic promise by increasing both…”
Get full text