Search Results - "Mendez, Lourdes M"

The Interplay Between the Genetic and Immune Landscapes of AML: Mechanisms and Implications for Risk Stratification and Therapy by Mendez, Lourdes M., Posey, Ryan R., Pandolfi, Pier Paolo

“…AML holds a unique place in the history of immunotherapy by virtue of being among the first malignancies in which durable remissions were achieved with…”
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Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas by Ding, B. Belinda, Yu, J. Jessica, Yu, Raymond Y.-L., Mendez, Lourdes M., Shaknovich, Rita, Zhang, Yonghui, Cattoretti, Giorgio, Ye, B. Hilda

“…Diffuse large B-cell lymphoma (DLBCL) consists of at least 2 phenotypic subtypes; that is, the germinal center B-cell–like (GCB-DLBCL) and the activated…”
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CtBP Is an Essential Corepressor for BCL6 Autoregulation by Mendez, Lourdes M., Polo, Jose M., Yu, J. Jessica, Krupski, Melissa, Ding, B. Belinda, Melnick, Ari, Ye, B. Hilda

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Clonal Hematopoiesis: Origins and determinants of evolution by Mendez, Lourdes M., Patnaik, Mrinal M.

“…The accrual of somatic mutations is a byproduct of aging. When a clone bearing a somatic genetic alteration, conferring comparative competitive advantage,…”
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Therapeutic Potential of Targeting the SUMO Pathway in Cancer by Kukkula, Antti, Ojala, Veera K, Mendez, Lourdes M, Sistonen, Lea, Elenius, Klaus, Sundvall, Maria

“…SUMOylation is a dynamic and reversible post-translational modification, characterized more than 20 years ago, that regulates protein function at multiple…”
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Germline NPM1 mutations lead to altered rRNA 2′-O-methylation and cause dyskeratosis congenita by Nachmani, Daphna, Bothmer, Anne H., Grisendi, Silvia, Mele, Aldo, Bothmer, Dietmar, Lee, Jonathan D., Monteleone, Emanuele, Cheng, Ke, Zhang, Yang, Bester, Assaf C., Guzzetti, Alison, Mitchell, Caitlin A., Mendez, Lourdes M., Pozdnyakova, Olga, Sportoletti, Paolo, Martelli, Maria-Paola, Vulliamy, Tom J., Safra, Modi, Schwartz, Schraga, Luzzatto, Lucio, Bluteau, Olivier, Soulier, Jean, Darnell, Robert B., Falini, Brunangelo, Dokal, Inderjeet, Ito, Keisuke, Clohessy, John G., Pandolfi, Pier Paolo

“…RNA modifications are emerging as key determinants of gene expression. However, compelling genetic demonstrations of their relevance to human disease are…”
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Circulating Protein Disulfide Isomerase Is Associated with Increased Risk of Thrombosis in JAK2 -Mutated Myeloproliferative Neoplasms by Sharda, Anish V, Bogue, Thomas, Barr, Alexandra, Mendez, Lourdes M, Flaumenhaft, Robert, Zwicker, Jeffrey I

“…Thromboembolic events (TE) are the most common complications of myeloproliferative neoplasms (MPN). Clinical parameters, including patient age and mutation…”
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Ipilimumab plus decitabine for patients with MDS or AML in posttransplant or transplant-naïve settings by Garcia, Jacqueline S., Flamand, Yael, Penter, Livius, Keng, Michael, Tomlinson, Benjamin K., Mendez, Lourdes M., Koller, Paul, Cullen, Nicole, Arihara, Yohei, Pfaff, Kathleen, Wolff, Jacquelyn O., Brunner, Andrew M., Galinsky, Ilene, Bashey, Asad, Antin, Joseph H., Cutler, Corey, Ho, Vincent, Jonas, Brian A., Luskin, Marlise R., Wadleigh, Martha, Winer, Eric S., Savell, Alexandra, Leonard, Rebecca, Robertson, Taylor, Davids, Matthew S., Streicher, Howard, Rodig, Scott J., Ritz, Jerome, Wu, Catherine J., DeAngelo, Daniel J., Neuberg, Donna, Stone, Richard M., Soiffer, Robert J.

“…Two articles in this week’s issue focus on the use of ipilimumab and decitabine for patients with myelodysplasia (MDS) and acute myeloid leukemia (AML) before…”
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Spectrum From Clonal Hematopoiesis to Myelodysplastic Neoplasm/Syndromes and Other Myeloid Neoplasms by Xie, Zhuoer, Chen, Evan C., Mendez, Lourdes M., Komrokji, Rami, Zeidan, Amer M.

“…Clonal hematopoiesis (CH) confers a high risk of aging-related diseases and hematologic malignancy. There are still significant knowledge gaps in identifying…”
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VWF maturation and release are controlled by 2 regulators of Weibel-Palade body biogenesis: exocyst and BLOC-2 by Sharda, Anish V., Barr, Alexandra M., Harrison, Joshua A., Wilkie, Adrian R., Fang, Chao, Mendez, Lourdes M., Ghiran, Ionita C., Italiano, Joseph E., Flaumenhaft, Robert

“…von Willebrand factor (VWF) is an essential hemostatic protein that is synthesized in endothelial cells and stored in Weibel-Palade bodies (WPBs)…”
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Clonal cytopenia of undetermined significance: definitions, risk and therapeutic targets by Taborda, Cristian C., Zeidan, Amer M., Mendez, Lourdes M.

“…Cancer-related somatic genetic alterations are detectable in the blood of individuals without hematologic malignancy, reflecting the outgrowth of a mutated…”
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Older patients with chronic myeloid leukemia face suboptimal molecular testing and tyrosine kinase inhibitor adherence by Shallis, Rory M., Wang, Rong, Zeidan, Amer M., Huntington, Scott F., Neparidze, Natalia, Stempel, Jessica M., Mendez, Lourdes M., Di, Mengyang, Ma, Xiaomei, Podoltsev, Nikolai A.

“…•Approximately 20% of older patients with CML had no molecular monitoring during the first year of TKI therapy.•Nearly half of the patients had suboptimal…”
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Alisertib plus induction chemotherapy in previously untreated patients with high-risk, acute myeloid leukaemia: a single-arm, phase 2 trial by Brunner, Andrew M, Blonquist, Traci M, DeAngelo, Daniel J, McMasters, Malgorzata, Fell, Geoffrey, Hermance, Nicole M, Winer, Eric S, Lindsley, R Coleman, Hobbs, Gabriela S, Amrein, Philip C, Hock, Hanno R, Steensma, David P, Garcia, Jacqueline S, Luskin, Marlise R, Stone, Richard M, Ballen, Karen K, Rosenblatt, Jacalyn, Avigan, David, Nahas, Myrna R, Mendez, Lourdes M, McAfee, Steven L, Moran, Jenna A, Bergeron, Meghan, Foster, Julia, Bertoli, Christina, Manning, Amity L, McGregor, Kristin L, Fishman, Kaitlyn M, Kuo, Frank C, Baltay, Michele T, Macrae, Molly, Burke, Meghan, Behnan, Tanya, Wey, Margaret C, Som, Tina T, Ramos, Aura Y, Rae, Jessica, Lombardi Story, Jennifer, Nelson, Nicole, Logan, Emma, Connolly, Christine, Neuberg, Donna S, Chen, Yi-Bin, Graubert, Timothy A, Fathi, Amir T

“…Increased aurora A kinase (AAK) expression occurs in acute myeloid leukaemia; AAK inhibition is a promising therapeutic target in this disease. We therefore…”
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Aberrant rRNA 2′-O-Methylation Causes Bone Marrow Failure and Defective Immune Function by Nachmani, Daphna, Mendez, Lourdes M., Pandolfi, Pier Paolo

“…RNA modifications are emerging as key determinants of development and disease. Understanding the mechanisms regulating their functional impact is crucial to…”
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Abstract 1694: CHIP and AML mutations dictate the composition of hematopoietic microenvironments by Posey, Ryan R., Mendez, Lourdes M., Lee, Jonathan D., Clohessy, John G., Pandolfi, Pier Paolo

“…Clonal Hematopoiesis of Indeterminate Potential (CHIP) is the age-associated acquisition of detectable stem cell mutations, known to predispose patients…”
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VWF Exocytosis and Biogenesis of Weibel Palade Bodies in Endothelial Cells Are Differentially Controlled By Interactions between Bloc-2 and the Exocyst Complex by Sharda, Anish V., Harrison, Joshua, Wilkie, Adrian R., Fang, Chao, Mendez, Lourdes M., Italiano, Joseph E., Flaumenhaft, Robert C.

“…von Willebrand factor (vWF) is an essential plasma hemostatic factor that also participates in pathophysiologic processes such as thrombosis, angiogenesis and…”
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Inhibition of ATR with AZD6738 (Ceralasertib) for the Treatment of Progressive or Relapsed Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia: Safety and Preliminary Activity from a Phase Ib/II Study by Brunner, Andrew M., Liu, Yiwen, Mendez, Lourdes M., Garcia, Jacqueline S., Amrein, Philip C., Neuberg, Donna S., Dean, Emma, Smith, Simon, Stone, Richard M., Fathi, Amir T., Walter, Matthew J., Graubert, Timothy A., Jacoby, Meagan A.

“…Introduction: Myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML) are advanced myeloid neoplasms with poor survival and no curative…”
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A Phase I Study of Asciminib (ABL001) in Combination with Dasatinib and Prednisone for BCR-ABL1-Positive ALL in Adults by Luskin, Marlise R., Stevenson, Kristen E., Mendez, Lourdes M., Wang, Eunice S., Wadleigh, Martha, Garcia, Jacqueline S., Stone, Richard M., An, Hyun Hwan, Hagopian, Ella, Galinsky, Ilene, Rae, Lindsey, Leonard, Rebecca, DeAngelo, Daniel J., Murakami, Mark A.

“…Introduction Oral tyrosine kinase inhibitors (TKIs) that inhibit the constitutively active ABL1 kinase have improved outcomes for BCR-ABL1+ acute lymphoblastic…”
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Induction Therapy for Gamma-Heavy Chain Disease with Bortezomib and Dexamethasone: A Case Report by Arnason, Jon E., Mendez, Lourdes M.

“…Abstract 5051 Heavy chain diseases (HCD) are rare B-cell lymphoproliferative disorders characterized by production of a monoclonal immunoglobulin without a…”
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Post-Transplant Vaccination with a Personalized Dendritic Cell/AML Fusion Cell Vaccine for Prevention of Relapse by Liegel, Jessica J., Bindal, Poorva, Stone, Richard M., Soiffer, Robert J., Stroopinsky, Dina, Cheloni, Giulia, Bisharat, Lina, Torres, Daniela, Rahimian, Maryam, Yoo, Seo Yeon, Logan, Emma K., Elavalakanar, Pavania, El Banna, Hassan, Hauser, Joshua, Koshy, Anita G., Romee, Rizwan, Ho, Vincent T., Neuberg, Donna S., Liu, Yiwen, Mendez, Lourdes M., Dias, Ajoy L., Ebert, Benjamin L., Kufe, Donald, Avigan, David, Rosenblatt, Jacalyn

“…Allogeneic transplantation is uniquely curative for a subset of patients with acute myeloid leukemia (AML) however, post-transplant relapse and graft versus…”
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