Bone marrow fibrosis (pseudo-myelofibrosis) in human kala-azar

Bone marrow fibrosis (pseudo-myelofibrosis) in human kala-azar

Thirty cases of human kala-azar were diagnosed by iliac crest biopsy and myeloculture. Histological analysis of 12 patients showed diffuse thickening of reticulin fibers. To the best of our knowledge, this is the third report describing secondary bone marrow fibrosis (myelofibrosis-like) associated...

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Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical Vol. 33; no. 4; pp. 363 - 366
Main Authors: Rocha Filho, F D, Ferreira, F V, Mendes, F de O, Ferreira, F N, Karbage, A, Alencar, M L, Costa, D
Format: Journal Article
Language:English
Published: Brazil Sociedade Brasileira de Medicina Tropical 01-07-2000
Sociedade Brasileira de Medicina Tropical - SBMT
Sociedade Brasileira de Medicina Tropical (SBMT)
Subjects:
Biopsy
Bone marrow
Bone Marrow - pathology
Bone marrow biopsy
Female
Fibers
Fibrosis - complications
Fibrosis - pathology
Human kala-azar
Humans
Leishmaniasis, Visceral - complications
Leishmaniasis, Visceral - pathology
Male
Myelofibrosis
TROPICAL MEDICINE
Bone marrow biopsy
Human kala-azar
Myelofibrosis
Calazar humano
Mielofibrose
Fibrose da medula óssea
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Summary:Thirty cases of human kala-azar were diagnosed by iliac crest biopsy and myeloculture. Histological analysis of 12 patients showed diffuse thickening of reticulin fibers. To the best of our knowledge, this is the third report describing secondary bone marrow fibrosis (myelofibrosis-like) associated with kala-azar. Patients with positive bone marrow fibrosis (pbmf = 12) were compared to patients without detectable bone marrow fibrosis (wbmf = 18). There were no significant differences in clinical and blood parameters following treatment. All patients showed regression of hepatosplenomegaly. Our findings suggest that associated bone marrow fibrosis is transient and did not interfere in the evolution of treated patients.
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ISSN:0037-8682
1678-9849
0037-8682
1678-9849
DOI:10.1590/S0037-86822000000400005