Search Results - "Mendelson, Michael M"

Prevalence of Familial Hypercholesterolemia in the 1999 to 2012 United States National Health and Nutrition Examination Surveys (NHANES) by de Ferranti, Sarah D, Rodday, Angie Mae, Mendelson, Michael M, Wong, John B, Leslie, Laurel K, Sheldrick, R Christopher

“…BACKGROUND—The prevalence of familial hypercholesterolemia (FH) is commonly reported as 1 in 500. European reports suggest a higher prevalence; the US FH…”
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Transgelin: a new gene involved in LDL endocytosis identified by a genome-wide CRISPR-Cas9 screen by Lucero, Diego, Dikilitas, Ozan, Mendelson, Michael M., Aligabi, Zahra, Islam, Promotto, Neufeld, Edward B., Bansal, Aruna T., Freeman, Lita A., Vaisman, Boris, Tang, Jingrong, Combs, Christian A., Li, Yuesheng, Voros, Szilard, Kullo, Iftikhar J., Remaley, Alan T.

“…A significant proportion of patients with elevated LDL and a clinical presentation of familial hypercholesterolemia do not carry known genetic mutations…”
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Methylome-wide Association Study of Atrial Fibrillation in Framingham Heart Study by Lin, Honghuang, Yin, Xiaoyan, Xie, Zhijun, Lunetta, Kathryn L., Lubitz, Steven A., Larson, Martin G., Ko, Darae, Magnani, Jared W., Mendelson, Michael M., Liu, Chunyu, McManus, David D., Levy, Daniel, Ellinor, Patrick T., Benjamin, Emelia J.

“…Atrial fibrillation (AF) is the most common cardiac arrhythmia, but little is known about the molecular mechanisms associated with AF arrhythmogenesis. DNA…”
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Aptamer Proteomics for Biomarker Discovery in Heart Failure With Preserved Ejection Fraction: The PARAGON-HF Proteomic Substudy by Patel-Murray, Natasha L, Zhang, Luqing, Claggett, Brian L, Xu, Dongchu, Serrano-Fernandez, Pablo, Healey, Margaret, Wandel, Simon, Chen, Chien-Wei, Jacob, Jaison, Xu, Huilei, Turner, Gordon M, Chutkow, William, Yates, Denise P, O'Donnell, Christopher J, Prescott, Margaret F, Lefkowitz, Martin, Gimpelewicz, Claudio R, Beste, Michael T, Zhao, Faye, Gou, Liangke, Desai, Akshay S, Jhund, Pardeep S, Packer, Milton, Pfeffer, Marc A, Redfield, Margaret M, Rouleau, Jean L, Zannad, Faiez, Zile, Michael R, McMurray, John J V, Mendelson, Michael M, Solomon, Scott D, Cunningham, Jonathan W

“…Prognostic markers and biological pathways linked to detrimental clinical outcomes in heart failure with preserved ejection fraction (HFpEF) remain…”
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Statin-Associated Myopathy in a Pediatric Preventive Cardiology Practice by Johnson, Philip K., BSc, Mendelson, Michael M., MD, ScM, Baker, Annette, PNP, Ryan, Heather H., RN, Warren, Shira, RN, Graham, Dionne, PhD, Griggs, Suzanne S., RD, Desai, Nirav K., MD, Yellen, Elizabeth, MD, Buckley, Lucy, MD, Zachariah, Justin P., MD, MPH, de Ferranti, Sarah D., MD, MPH

“…Objectives To describe muscle-related statin adverse effects in real-world pediatric practice. Study design Using prospectively collected quality improvement…”
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Correlates of Achieving Statin Therapy Goals in Children and Adolescents with Dyslipidemia by Mendelson, Michael M., MD, ScM, Regh, Todd, MStat, Chan, James, MSc, Baker, Annette, NP, Ryan, Heather Harker, RN, Palumbo, Nicole, NP, Johnson, Philip K., BSc, Griggs, Suzanne, RD, Boghani, Meera, RD, Desai, Nirav K., MD, Yellen, Elizabeth, MD, Buckley, Lucy, MD, Gillman, Matthew W., MD, SM, Zachariah, Justin P., MD, MPH, Graham, Dionne, PhD, de Ferranti, Sarah D., MD, MPH

“…Objective To determine the real-world effectiveness of statins and impact of baseline factors on low-density lipoprotein cholesterol (LDL-C) reduction among…”
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Epigenome-Wide Association Study of Soluble Tumor Necrosis Factor Receptor 2 Levels in the Framingham Heart Study by Mendelson, Michael M, Johannes, Roby, Liu, Chunyu, Huan, Tianxiao, Yao, Chen, Miao, Xiao, Murabito, Joanne M, Dupuis, Josée, Levy, Daniel, Benjamin, Emelia J, Lin, Honghuang

“…Transmembrane tumor necrosis factor (TNF) receptors are involved in inflammatory, apoptotic, and proliferative processes. In the bloodstream, soluble TNF…”
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Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation by Di Gioia, Marco, Spreafico, Roberto, Springstead, James R., Mendelson, Michael M., Joehanes, Roby, Levy, Daniel, Zanoni, Ivan

“…Pathogen-associated molecular patterns (PAMPs) have the capacity to couple inflammatory gene expression to changes in macrophage metabolism, both of which…”
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Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction and Coronary Heart Disease by Agha, Golareh, Mendelson, Michael M, Ward-Caviness, Cavin K, Joehanes, Roby, Huan, TianXiao, Gondalia, Rahul, Salfati, Elias, Brody, Jennifer A, Fiorito, Giovanni, Bressler, Jan, Chen, Brian H, Ligthart, Symen, Guarrera, Simonetta, Colicino, Elena, Just, Allan C, Wahl, Simone, Gieger, Christian, Vandiver, Amy R, Tanaka, Toshiko, Hernandez, Dena G, Pilling, Luke C, Singleton, Andrew B, Sacerdote, Carlotta, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Li, Yun, Zhang, Guosheng, Stewart, James D, Floyd, James S, Wiggins, Kerri L, Rotter, Jerome I, Multhaup, Michael, Bakulski, Kelly, Horvath, Steven, Tsao, Philip S, Absher, Devin M, Vokonas, Pantel, Hirschhorn, Joel, Fallin, M Daniele, Liu, Chunyu, Bandinelli, Stefania, Boerwinkle, Eric, Dehghan, Abbas, Schwartz, Joel D, Psaty, Bruce M, Feinberg, Andrew P, Hou, Lifang, Ferrucci, Luigi, Sotoodehnia, Nona, Matullo, Giuseppe, Peters, Annette, Fornage, Myriam, Assimes, Themistocles L, Whitsel, Eric A, Levy, Daniel, Baccarelli, Andrea A

“…DNA methylation is implicated in coronary heart disease (CHD), but current evidence is based on small, cross-sectional studies. We examined blood DNA…”
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Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction and Coronary Heart Disease: A Longitudinal Study of 11 461 Participants From Population-Based Cohorts by Agha, Golareh, Mendelson, Michael M, Ward-Caviness, Cavin K, Joehanes, Roby, Huan, TianXiao, Gondalia, Rahul, Salfati, Elias, Brody, Jennifer A, Fiorito, Giovanni, Bressler, Jan, Chen, Brian H, Ligthart, Symen, Guarrera, Simonetta, Colicino, Elena, Just, Allan C, Wahl, Simone, Gieger, Christian, Vandiver, Amy R, Tanaka, Toshiko, Hernandez, Dena G, Pilling, Luke C, Singleton, Andrew B, Sacerdote, Carlotta, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Li, Yun, Zhang, Guosheng, Stewart, James D, Floyd, James S, Wiggins, Kerri L, Rotter, Jerome I, Multhaup, Michael, Bakulski, Kelly, Horvath, Steven, Tsao, Philip S, Absher, Devin M, Vokonas, Pantel, Hirschhorn, Joel, Fallin, M Daniele, Liu, Chunyu, Bandinelli, Stefania, Boerwinkle, Eric, Dehghan, Abbas, Schwartz, Joel D, Psaty, Bruce M, Feinberg, Andrew P, Hou, Lifang, Ferrucci, Luigi, Sotoodehnia, Nona, Matullo, Giuseppe, Peters, Annette, Fornage, Myriam, Assimes, Themistocles L, Whitsel, Eric A, Levy, Daniel, Baccarelli, Andrea A

“…BACKGROUND:DNA methylation is implicated in coronary heart disease (CHD), but current evidence is based on small, cross-sectional studies. We examined blood…”
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Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population: EPIC-Norfolk Study by Cardona, Alexia, Day, Felix R, Perry, John R B, Loh, Marie, Chu, Audrey Y, Lehne, Benjamin, Paul, Dirk S, Lotta, Luca A, Stewart, Isobel D, Kerrison, Nicola D, Scott, Robert A, Khaw, Kay-Tee, Forouhi, Nita G, Langenberg, Claudia, Liu, Chunyu, Mendelson, Michael M, Levy, Daniel, Beck, Stephan, Leslie, R David, Dupuis, Josée, Meigs, James B, Kooner, Jaspal S, Pihlajamäki, Jussi, Vaag, Allan, Perfilyev, Alexander, Ling, Charlotte, Hivert, Marie-France, Chambers, John C, Wareham, Nicholas J, Ong, Ken K

“…Epigenetic changes may contribute substantially to risks of diseases of aging. Previous studies reported seven methylation variable positions (MVPs) robustly…”
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Epigenetic Age Acceleration: A Biological Doomsday Clock for Cardiovascular Disease? by Mendelson, Michael M

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DNA Methylation Signatures of Depressive Symptoms in Middle-aged and Elderly Persons: Meta-analysis of Multiethnic Epigenome-wide Studies by Story Jovanova, Olivera, Nedeljkovic, Ivana, Spieler, Derek, Walker, Rosie M, Liu, Chunyu, Luciano, Michelle, Bressler, Jan, Brody, Jennifer, Drake, Amanda J, Evans, Kathryn L, Gondalia, Rahul, Kunze, Sonja, Kuhnel, Brigitte, Lahti, Jari, Lemaitre, Rozenn N, Marioni, Riccardo E, Swenson, Brenton, Himali, Jayandra Jung, Wu, Hongsheng, Li, Yun, McRae, Allan F, Russ, Tom C, Stewart, James, Wang, Zhiying, Zhang, Guosheng, Ladwig, Karl-Heinz, Uitterlinden, Andre G, Guo, Xiuqing, Peters, Annette, Räikkönen, Katri, Starr, John M, Waldenberger, Melanie, Wray, Naomi R, Whitsel, Eric A, Sotoodehnia, Nona, Seshadri, Sudha, Porteous, David J, van Meurs, Joyce, Mosley, Thomas H, McIntosh, Andrew M, Mendelson, Michael M, Levy, Daniel, Hou, Lifang, Eriksson, Johan G, Fornage, Myriam, Deary, Ian J, Baccarelli, Andrea, Tiemeier, Henning, Amin, Najaf

“…Depressive disorders arise from a combination of genetic and environmental risk factors. Epigenetic disruption provides a plausible mechanism through which…”
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Improving Cardiovascular Health in a Pediatric Preventive Cardiology Practice by Gooding, Holly C., Gauvreau, Kimberlee, Bachman, Jennifer, Baker, Annette, Griggs, S. Skylar, Hartz, Jacob, Huang, Yisong, Mendelson, Michael M., Palfrey, Hannah, de Ferranti, Sarah D.

“…Poor childhood cardiovascular health translates into poor adult cardiovascular health. We hypothesized care in a preventive cardiology clinic would improve…”
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Aptamer Proteomics for Biomarker Discovery in Heart Failure With Reduced Ejection Fraction by Zhang, Luqing, Cunningham, Jonathan W., Claggett, Brian L., Jacob, Jaison, Mendelson, Michael M., Serrano-Fernandez, Pablo, Kaiser, Sergio, Yates, Denise P., Healey, Margaret, Chen, Chien-Wei, Turner, Gordon M., Patel-Murray, Natasha L., Zhao, Faye, Beste, Michael T., Laramie, Jason M., Abraham, William T., Jhund, Pardeep S., Kober, Lars, Packer, Milton, Rouleau, Jean, Zile, Michael R., Prescott, Margaret F., Lefkowitz, Martin, McMurray, John J.V., Solomon, Scott D., Chutkow, William

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Epigenetics: Is the Mode of Conception a Marker for Future Cardiovascular Risk? by Weinrauch, Larry A., Gerhard-Herman, Marie D., Mendelson, Michael M.

“…[Display omitted]…”
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A Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Nonalcoholic Fatty Liver Disease by Ma, Jiantao, Nano, Jana, Ding, Jingzhong, Zheng, Yinan, Hennein, Rachel, Liu, Chunyu, Speliotes, Elizabeth K, Huan, Tianxiao, Song, Ci, Mendelson, Michael M, Joehanes, Roby, Long, Michelle T, Liang, Liming, Smith, Jennifer A, Reynolds, Lindsay M, Ghanbari, Mohsen, Muka, Taulant, van Meurs, Joyce B J, Alferink, Louise J M, Franco, Oscar H, Dehghan, Abbas, Ratliff, Scott, Zhao, Wei, Bielak, Lawrence, Kardia, Sharon L R, Peyser, Patricia A, Ning, Hongyan, VanWagner, Lisa B, Lloyd-Jones, Donald M, Carr, John Jeffrey, Greenland, Philip, Lichtenstein, Alice H, Hu, Frank B, Liu, Yongmei, Hou, Lifang, Darwish Murad, Sarwa, Levy, Daniel

“…Nonalcoholic fatty liver disease (NAFLD) is a risk factor for type 2 diabetes (T2D). We aimed to identify the peripheral blood DNA methylation signature of…”
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Machine Learning for Proteomic Risk Scores in Heart Failure by Xu, Dongchu, Cunningham, Jonathan, Marti-Castellote, Pablo-Miki, Zhang, Luqing, Patel-Murray, Natasha L, Prescott, Margaret F, Chutkow, William, Mendelson, Michael M, Solomon, Scott D, Claggett, Brian L

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Childhood Environmental Tobacco Smoke Exposure: A Smoking Gun for Atherosclerosis in Adulthood by Mendelson, Michael M, de Ferranti, Sarah D

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Clinical characteristics of heart failure with reduced ejection fraction patients with rare pathogenic variants in dilated cardiomyopathy‐associated genes: A subgroup analysis of the PARADIGM‐HF trial by Barat, Ana, Chen, Chien‐Wei, Patel‐Murray, Natasha, McMurray, John J.V., Packer, Milton, Solomon, Scott D., Desai, Akshay S., Rouleau, Jean L., Zile, Michael R., Attari, Zenab, Zhang, Cong, Xu, Huilei, Hartman, Nicole, Hon, Claudia, Healey, Margaret, Chutkow, William, O'Donnell, Christopher J., Jacob, Jaison, Lefkowitz, Marty, Mendelson, Michael M., Wandel, Simon, Yates, Denise, Gimpelewicz, Claudio

“…Aims To evaluate the prevalence of pathogenic variants in genes associated with dilated cardiomyopathy (DCM) in a clinical trial population with heart failure…”
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