Search Results - "Mencher, Simon K."

Natura-Alpha Targets Forkhead Box M1 and Inhibits Androgen-Dependent and -Independent Prostate Cancer Growth and Invasion by YIRONG LI, LIGR, Martin, MENCHER, Simon K, LEPOR, Hebert, WANG, Long G, LEE, Peng, MCCARRON, James P, DANIELS, Garrett, ZHANG, David, XIN ZHAO, FEI YE, JINHUA WANG, XIAOMEI LIU, OSMAN, Iman

“…The development of new effective therapeutic agents with minimal side effects for prostate cancer (PC) treatment is much needed. Indirubin, an active molecule…”
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Interaction of a small molecule Natura-α and STAT3-SH2 domain to block Y705 phosphorylation and inhibit lupus nephritis by Chiao, J.W., Melikian, Maxime, Han, Liying, Xue, Chengsen, Tsao, Allen, Wang, Luxi, Mencher, Simon K., Fallon, John, Solangi, Karim, Bertho, Gildas, Wang, Long G.

“…Natura-α binds SH2 domain of STAT3, forms H-bonds with Glu594 and Arg609, preventing Y705 phosphorylation. The efficacy was evaluated in lupus mice, Natura-α…”
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Treatment of collagen-induced arthritis by Natura-α via regulation of Th-1/Th-17 responses by Glatigny, Simon, Blaton, Marie-Agnès, Mencher, Simon K, Mistou, Sylvie, Lucas, Bruno, Fournier, Catherine, Wang, Long G, Chiocchia, Gilles

“…Cytokines and CD4⁺ Th cells play a crucial role in the pathogenesis of rheumatoid arthritis. Among the Th populations, Th-1 and Th-17 have been described as…”
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Promiscuous drugs compared to selective drugs (promiscuity can be a virtue) by Mencher, Simon K, Wang, Long G

“…The word selectivity describes a drug's ability to affect a particular cell population in preference to others. As part of the current state of art in the…”
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The biological basis for the use of an anti-androgen and a 5-alpha-reductase inhibitor in the treatment of recurrent prostate cancer: Case report and review by Wang, Long G, Mencher, Simon K, McCarron, J P, Ferrari, Anna C

“…Although many prostate cancer cases relapse to a hormone-insensitive state, endocrine therapy involving androgen depletion by orchiectomy or by treatment with…”
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