Search Results - "Menard, P R"

New 4-Point Pharmacophore Method for Molecular Similarity and Diversity Applications:  Overview of the Method and Applications, Including a Novel Approach to the Design of Combinatorial Libraries Containing Privileged Substructures by Mason, Jonathan S, Morize, Isabelle, Menard, Paul R, Cheney, Daniel L, Hulme, Christopher, Labaudiniere, Richard F

“…A new 4-point pharmacophore method for molecular similarity and diversity that rapidly calculates all potential pharmacophores/pharmacophoric shapes for a…”
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Angiotensin-converting enzyme inhibitors: new orally active 1,4-thiazepine-2,5-diones, 1,4-thiazine-2,5-diones, and 1,4-benzothiazepine-2,5-diones possessing antihypertensive activity by Skiles, Jerry W, Suh, John T, Williams, Bruce E, Menard, Paul R, Barton, Jeffrey N, Loev, Bernard, Jones, Howard, Neiss, Edward S, Schwab, Alfred

“…The preparation of a series of 1,4-thiazepine-2,5-diones, 1,4-thiazine-2,5-diones, and 1,4-benzothiazepine-2,5-diones and their ability in inhibiting the…”
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Angiotensin converting enzyme inhibitors. (Mercaptoaroyl)amino acids by Menard, Paul R, Suh, John T, Jones, Howard, Loev, Bernard, Neiss, Edward S, Wilde, Joyce, Schwab, Alfred, Mann, William S

“…A series of (mercaptoaroyl)amino acids and related compounds was synthesized and tested for ability to inhibit angiotensin converting enzyme (ACE). The most…”
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Chemistry Space Metrics in Diversity Analysis, Library Design, and Compound Selection by Menard, Paul R, Mason, Jonathan S, Morize, Isabelle, Bauerschmidt, Susanne

“…DiverseSolutions software was used to generate a “universal” chemistry space that can be used as a standard for profiling most structural sets of interest. A…”
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Rational Screening Set Design and Compound Selection:  Cascaded Clustering by Menard, Paul R, Lewis, Richard A, Mason, Jonathan S

“…The use of cascaded clustering is reported. This technique was developed to permit the application of Jarvis-Patrick clustering based on structural…”
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Synthesis and diversity analysis of lead discovery piperazine-2-carboxamide libraries by Herpin, T F, Morton, G C, Dunn, A K, Fillon, C, Menard, P R, Tang, S Y, Salvino, J M, Labaudinière, R F

“…A Lead Discovery Library of piperazine-2-carboxamide derivatives was produced for general screening. This paper discloses two novel solid phase synthetic…”
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Angiotensin converting enzyme inhibitors. 9. Novel [[N-(1-carboxyl-3-phenylpropyl)amino]acyl]glycine derivatives with diuretic activity by Barton, Jeffrey N, Piwinski, John J, Skiles, Jerry W, Regan, John R, Menard, Paul R, Desai, Rohit, Golec, F. S, Reilly, Laurence W, Goetzen, Thomas

“…A series of molecules 1 having sulfonamide diuretic moieties covalently linked to non-sulfhydryl angiotensin-converting enzyme inhibitors (ACEI) were prepared…”
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Angiotensin converting enzyme inhibitors. 10. Aryl sulfonamide substituted N-[1-carboxy-3-phenylpropyl]-L-alanyl-L-proline derivatives as novel antihypertensives by Mencel, James J, Regan, John R, Barton, Jeffrey, Menard, Paul R, Bruno, Joseph G, Calvo, Raul R, Kornberg, Brian E, Schwab, Alfred, Neiss, Edward S, Suh, John T

“…Compounds 1a-g consisting of enalaprilat covalently bonded to aryl sulfonamides, including several known thiazide diuretics, were synthesized and tested for…”
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Angiotensin converting enzyme inhibiors. 10. Aryl sulfonamide substitued N-[1-carboxy-3-phenylpropyl]-L-alanyl-L-proline derivatives as novel antihypertensives by MENCEL, J. J, REGAN, J. R, BARTON, J, MENARD, P. R, BRUNO, J. G, CALVO, R. R, KORNBERG, B. E, SCHWAB, A, NEISS, E. S, SUH, J. T

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Angiotensin-converting enzyme inhibitors. 9.1 novel [[N-(1-carboxy-3-phenylpropyl)amino]acyl]glycine derivatives with diuretic activity by BARTON, J. N, PIWINSKI, J. J, WARUS, J. D, SCHWAB, A, SAMUELS, A. I, NEISS, E. S, SUH, J. T, SKILES, J. W, REGAN, J. R, MENARD, P. R, DESAI, R, GOLEC, F. S, REILLY, L. W, GOETZEN, T, UENG, S.-N

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Angiotensin-converting enzyme inhibitors. 9. Novel ((N-(-carboxy-3-phenylpropyl)-amino)acyl)glycine derivatives with diuretic activity by Barton, J N, Piwinski, J J, Skiles, J W, Regan, J R, Menard, PR, Desai, R, Golec, F S, Reilly, L W, Suhn, J T

“…A series of molecules 1 having sulfonamide diuretic moieties covalently linked to non-sulfhydryl angiotensin-converting enzyme inhibitors (ACEI) were prepared…”
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Angiotensin converting inhibitors. (Mercaptoaroyl)amino acids by Menard, PR, Suh, J T, Jones, H, Leov, B, Neiss, E S, Wilde, J, Schwab, A, Mann, W S

“…A series of (mercaptoaroyl)amino acids and related compounds was synthesized and tested for ability to inhibit angiotensin converting enzyme (ACE). The most…”
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