ANALYSING THE RELATIONSHIP BETWEEN SFLT-1/PLGF RATIO AND PREMATURE BIRTH

Objective: To analyse the relationship between sFlt-1/PlGF ratio and the occurrence of premature birth (<37 week) Design and method: An observational, retrospective, cross-sectional study that includes pregnant women who under sFlt-1/PlGF ratio determination since January until September 2022 in...

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Published in:	Journal of hypertension Vol. 42; no. Suppl 1; pp. e315 - e316
Main Authors:	Rodríguez, Claudia Martín, Morales, Eduardo Martínez, González, Esther Rubio, Sánchez, Paula López, Testillano, Lucía Martín, Pujol, Javier Relea, García, Irene García, Sánchez, Paola Carolina Villegas, García, M Mercedes Pérez, Fernández, M Isabel Galán, Arroyo, Ana María Huerta, Briales, Paula Sánchez, Vidas, María Marques, Recio, María De Valdenebro, Sánchez, Ana Muñoz, Menéndez, Estefanya Lisset García, Marín, Darío Janeiro, Salazar, María Luisa Serrano, Carratalá, Rosario Llópez, Pérez, Jose María Portolés
Format:	Journal Article
Language:	English
Published:	01-05-2024
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Summary:	Objective: To analyse the relationship between sFlt-1/PlGF ratio and the occurrence of premature birth (<37 week) Design and method: An observational, retrospective, cross-sectional study that includes pregnant women who under sFlt-1/PlGF ratio determination since January until September 2022 in a tertiary hospital. Baseline characteristics and data related with the pregnancy, birth and the development of hypertensive disorders of pregnancy (HDP) were included. A multivariate logistic regression was applied to identify risk factors. Results: Out of 109 recruited patients, 104 were analyzed (5 were excluded due to the lost of follow-up). The mean age was 33.9 years (SD 5.0), 52.5% were primiparous and 4.8% were twin pregnancies. 7.7% had pre-pregnancy hypertension and 15.4% had a prior HDP. Additional data are specified in Table 1. During pregnancy, a total of 64.4% women developed HDP; 45.2% presented pre-eclampsia (PE) / eclampsia; 4.8% had chronic hypertension and 14.4% had gestational hypertension. The mean week of birth presentation was 37.9 (SD 2.4).18.3% were preterm births (<37 week). Among patients with PE, 30.6% had a preterm birth compared with 7.3% of preterm births in cases without PE (p-value 0.002). Fifty-four percent women obtained a pathological sFlt-1/PlGF ratio (>38). 30.4% of patients with a pathological ratio underwent preterm birth, whereas only 4.2% with a normal ratio developed preterm birth (p-value 0.001). 73.7% of preterm births had a ratio >65, and 26.3% had a ratio between 26-65. No differences in neonate weight (p- value 0.058) between women with a pathological ratio (2.9 kg, SD 90.1) and a normal one (3.1 kg, SD 82.4) In multivariate analysis, excluding twin pregnancies, patients with a pathological ratio had a higher risk of preterm birth, OR 5.2 (CI95% [1.0-28.0]), regardless of patient's age or the presence or not of preeclampsia. Conclusions: The sFlt-1/PlGF ratio could be a valuable tool to predict the risk of preterm birth, as patients with a pathological ratio had higher risk of preterm birth, regardless women's age or the presence of preeclampsia. More studies are necessary to establish thisratio in clinical practice for this purpose.
ISSN:	0263-6352 1473-5598
DOI:	10.1097/01.hjh.0001022788.97769.31