Application of central composite design for the optimization of on-line solid phase extraction of Cu2+ by calix[4]arene bonded silica resin

Present study deals with the optimization of on-line solid phase extraction of Cu2+ using calix[4]arene based silica resin by the assessment of central composite design of response surface methodology. The immobilized resin was characterized with FT-IR and SEM techniques. The data obtained from expe...

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Bibliographic Details
Published in:	Chemometrics and intelligent laboratory systems Vol. 146; pp. 158 - 168
Main Authors:	Memon, Fakhar N., Ayyilidiz, H. Filiz, Kara, Hüseyin, Memon, Shahabuddin, Kenar, Adnan, Leghari, Muhammad Khan, Topkafa, Mustafa, Sherazi, Syed Tufail Hussain, Memon, Naeem Ahmed, Durmaz, Fatih, Tarhan, Ismail
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 15-08-2015
Subjects:	Atomic absorption spectroscopy Break through curve Calixarene Chemometrics solid phase extraction Copper Break through curve Chemometrics solid phase extraction Calixarene Atomic absorption spectroscopy Copper
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Summary:	Present study deals with the optimization of on-line solid phase extraction of Cu2+ using calix[4]arene based silica resin by the assessment of central composite design of response surface methodology. The immobilized resin was characterized with FT-IR and SEM techniques. The data obtained from experimental program of central composite design was used to model the parameters that significantly affect on Cu2+ extraction. The variables chosen were metal ion concentration, pH, and temperature. Second-order quadratic model was used to approximate the effect of variables on extraction efficiency. Furthermore, suggested model was also validated with the analysis of variance. The predicted values were in good agreement with experimental results, suggesting proficient application of central composite design as an economical alternative to acquire maximum amount of information for the modeling of on-line solid phase extraction with little number of experiments. Additionally, data obtained for different concentrations was analyzed by Freundlich, Langmuir, D-R isotherms, and Scatchard plot analysis. The results suggested that Langmuir isotherm was best fit model with R20.99, the energy calculated from D-R isotherm was 15.14KJ/mol suggesting that chemical force is involved in sorption process. The method was also validated for its linearity, accuracy, and precision. •Synthesis and characterization of a new calix[4]arene based resin•Optimization of on-line SPE for Cu2+ by assessment of CCD•Proposed second-order polynomial model was found to be significant.•The optimized method was validated for its linearity, precision, and accuracy.•Methodology is a valuable tool for monitoring toxic metal ions in column.
ISSN:	0169-7439 1873-3239
DOI:	10.1016/j.chemolab.2015.05.020