Search Results - "Memme, Jonathan M"

Maintenance of Skeletal Muscle Mitochondria in Health, Exercise, and Aging by Hood, David A, Memme, Jonathan M, Oliveira, Ashley N, Triolo, Matthew

“…Mitochondria are critical organelles responsible for regulating the metabolic status of skeletal muscle. These organelles exhibit remarkable plasticity by…”
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Exercise and mitochondrial health by Memme, Jonathan M., Erlich, Avigail T., Phukan, Geetika, Hood, David A.

“…Mitochondrial health is an important mediator of cellular function across a range of tissues, and as a result contributes to whole‐body vitality in health and…”
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Mitochondrial Bioenergetics and Turnover during Chronic Muscle Disuse by Memme, Jonathan M., Slavin, Mikhaela, Moradi, Neushaw, Hood, David A.

“…Periods of muscle disuse promote marked mitochondrial alterations that contribute to the impaired metabolic health and degree of atrophy in the muscle. Thus,…”
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Activating transcription factor 4 regulates mitochondrial content, morphology, and function in differentiating skeletal muscle myotubes by Memme, Jonathan M, Sanfrancesco, Victoria C, Hood, David A

“…Mitochondrial function is widely recognized as a major determinant of health, emphasizing the importance of understanding the mechanisms promoting…”
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Molecular Basis for the Therapeutic Effects of Exercise on Mitochondrial Defects by Memme, Jonathan M, Hood, David A

“…Mitochondrial dysfunction is common to many organ system disorders, including skeletal muscle. Aging muscle and diseases of muscle are often accompanied by…”
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Dimorphic effect of TFE3 in determining mitochondrial and lysosomal content in muscle following denervation by Oliveira, Ashley N, Memme, Jonathan M, Wong, Jenna, Hood, David A

“…Muscle atrophy is a common consequence of the loss of innervation and is accompanied by mitochondrial dysfunction. Mitophagy is the adaptive process through…”
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p53 regulates skeletal muscle mitophagy and mitochondrial quality control following denervation-induced muscle disuse by Memme, Jonathan M., Oliveira, Ashley N., Hood, David A.

“…Persistent inactivity promotes skeletal muscle atrophy, marked by mitochondrial aberrations that affect strength, mobility, and metabolic health leading to the…”
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Function of specialized regulatory proteins and signaling pathways in exercise-induced muscle mitochondrial biogenesis by Erlich, Avigail T., Tryon, Liam D., Crilly, Matthew J., Memme, Jonathan M., Moosavi, Zahra S. Mesbah, Oliveira, Ashley N., Beyfuss, Kaitlyn, Hood, David A.

“…Skeletal muscle mitochondrial content and function are regulated by a number of specialized molecular pathways that remain to be fully defined. Although a…”
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Recent advances in mitochondrial turnover during chronic muscle disuse by Tryon, Liam D., Vainshtein, Anna, Memme, Jonathan M., Crilly, Matthew J., Hood, David A.

“…Chronic muscle disuse, such as that resulting from immobilization, denervation, or prolonged physical inactivity, produces atrophy and a loss of mitochondria,…”
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Chronology of UPR activation in skeletal muscle adaptations to chronic contractile activity by Memme, Jonathan M, Oliveira, Ashley N, Hood, David A

“…The mitochondrial and endoplasmic reticulum unfolded protein responses (UPR(mt) and UPR(ER)) are important for cellular homeostasis during stimulus-induced…”
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Determining the role of ATF4 in the regulation of mitochondrial remodeling during myotube differentiation and contractile activity by Memme, Jonathan M., Sanfrancesco, Victoria C., Hood, David A.

“…ATF4 is a transcriptional regulator that is selectively induced in response to cellular stress conditions, such as exercise, through the activation of the…”
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Role of TFE3 in Mitochondrial Adaptations to Skeletal Muscle Disuse by Oliveira, Ashley N., Memme, Jonathan M., Wong, Jenna, Hood, David A.

“…Prolonged muscle disuse is accompanied by a phenotypic shift characterized by declines in mitochondrial content and function within skeletal muscle. This loss…”
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Scientific meeting report: International Biochemistry of Exercise 2022 by Vainshtein, Anna, Slavin, Mikhaela B, Cheng, Arthur J, Memme, Jonathan M, Oliveira, Ashley N, Perry, Christopher G R, Abdul-Sater, Ali A, Belcastro, Angelo N, Riddell, Michael C, Triolo, Matthew, Haas, Tara L, Roudier, Emilie, Hood, David A

“…Exercise is one of the only nonpharmacological remedies known to counteract genetic and chronic diseases by enhancing health and improving life span. Although…”
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The importance of TP53/p53 in regulating the mitophagy-lysosomal machinery in muscle following disuse by Memme, Jonathan M., Oliveira, Ashley N., Hood, David A.

“…Since being discovered in the late 1990s, TP53/TRP53/p53 has been a focal point of research, lauded for its role as a tumor-suppressor protein. Considerable…”
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Application of Chronic Stimulation to Study Contractile Activity-induced Rat Skeletal Muscle Phenotypic Adaptations by Kim, Yuho, Memme, Jonathan M, Hood, David A

“…Skeletal muscle is a highly adaptable tissue, as its biochemical and physiological properties are greatly altered in response to chronic exercise. To…”
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Mitochondrial Quality Control Regulation by p53 During Disuse‐Induced Atrophy by Memme, Jonathan M, Oliveira, Ashley N, Hood, David A

“…Chronic muscle disuse, as observed in conditions of aging, prolonged bedrest, or limb immobilization, contributes to progressive atrophy of the affected…”
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Inhibition of UPR ER Does Not Impair Signaling to Mitochondrial Biogenesis During Chronic Contractile Activity by Oliveira, Ashley N, Memme, Jonathan M, Hood, David

“…Abstract only Cellular stresses that perturb the protein folding environment can be detrimental to cell health and may provoke apoptosis. In order to combat…”
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Application of Chronic Stimulation to Study Contractile Activity-induced Rat Skeletal Muscle Phenotypic Adaptations by Kim, Yuho, Memme, Jonathan M., Hood, David A.

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