Search Results - "Melvin, Matt"

Nicotine levels and presence of selected tobacco-derived toxins in tobacco flavoured electronic cigarette refill liquids by Farsalinos, Konstantinos E, Gillman, I Gene, Melvin, Matt S, Paolantonio, Amelia R, Gardow, Wendy J, Humphries, Kathy E, Brown, Sherri E, Poulas, Konstantinos, Voudris, Vassilis

“…Some electronic cigarette (EC) liquids of tobacco flavour contain extracts of cured tobacco leaves produced by a process of solvent extraction and steeping…”
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Influence of Nitrite on Formation of Tobacco-Specific Nitrosamines in Electronic Cigarette Liquids and Aerosols by Jin, Xiaohong C., Wagner, Karl A., Melvin, Matt S., Smith, Donna C., Pithawalla, Yezdi B., Gardner, William P., Avery, Karen C., Karles, Georgios D.

“…Tobacco-specific nitrosamine (TSNA) formation occurred during aerosol generation from select commercial cig-a-like e-cigarette products. To understand the…”
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An evaluation of electronic cigarette formulations and aerosols for harmful and potentially harmful constituents (HPHCs) typically derived from combustion by Wagner, Karl A., Flora, Jason W., Melvin, Matt S., Avery, Karen C., Ballentine, Regina M., Brown, Anthony P., McKinney, Willie J.

“…U.S. FDA draft guidance recommends reporting quantities of designated harmful and potentially harmful constituents (HPHCs) in e-cigarette e-liquids and…”
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Non-Targeted Analysis Using Gas Chromatography-Mass Spectrometry for Evaluation of Chemical Composition of E-Vapor Products by Shah, Niti H, Noe, Michael R, Agnew-Heard, Kimberly A, Pithawalla, Yezdi B, Gardner, William P, Chakraborty, Saibal, McCutcheon, Nicholas, Grisevich, Hannah, Hurst, Thomas J, Morton, Michael J, Melvin, Matt S, Miller Iv, John H

“…The Premarket Tobacco Product Applications (PMTA) guidance issued by the Food and Drug Administration for electronic nicotine delivery systems (ENDSs)…”
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Determination of Formaldehyde Yields in E-Cigarette Aerosols: An Evaluation of the Efficiency of the DNPH Derivatization Method by Jin, Xiaohong C., Ballentine, Regina M., Gardner, William P., Melvin, Matt S., Pithawalla, Yezdi B., Wagner, Karl A., Avery, Karen C., Sharifi, Mehran

“…Recent reports have suggested that (1) formaldehyde levels (measured as a hydrazone derivative using the DNPH derivatization method) in Electronic Nicotine…”
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Formation of Diacetyl and Other α‑Dicarbonyl Compounds during the Generation of E‑Vapor Product Aerosols by Melvin, Matt S, Avery, Karen C, Ballentine, Regina M, Flora, Jason W, Gardner, William, Karles, Georgios D, Pithawalla, Yezdi B, Smith, Donna C, Ehman, Kimberly D, Wagner, Karl A

“…Exposure to diacetyl (DA) has been linked to the respiratory condition bronchiolitis obliterans. Previous research has demonstrated that DA and other…”
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Gas Chromatography-Mass Spectrometry Method to Quantify Benzo[a]Pyrene in Tobacco Products by Wagner, Karl A., Huang, Chorng B., Melvin, Matt S., Ballentine, Regina, Meruva, Naren K., Flora, Jason W.

“…Abstract The USA Food and Drug Administration (FDA) established benzo[a]pyrene (B[a]P) as a harmful and potentially harmful constituent (HPHC) found in tobacco…”
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Development of a Scalable Synthesis of a Pyridinyl-3-azabicyclononene, a Novel Nicotinic Partial Agonist by Breining, Scott R, Genus, John F, Mitchener, J. Pike, Cuthbertson, Timothy J, Heemstra, Ronald, Melvin, Matt S, Dull, Gary M, Yohannes, Daniel

“…The process research and development of two syntheses of a novel nicotinic partial agonist, TC-8817 ((+)-5), are described. The original Medicinal Chemistry…”
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Double-Strand DNA Cleavage by Copper·Prodigiosin by Melvin, Matt S, Tomlinson, John T, Saluta, Gilda R, Kucera, Gregory L, Lindquist, Neils, Manderville, Richard A

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Zinc and Copper Complexes of Prodigiosin:  Implications for Copper-Mediated Double-Strand DNA Cleavage by Park, Gyungse, Tomlinson, John T, Melvin, Matt S, Wright, Marcus W, Day, Cynthia S, Manderville, Richard A

“…Zinc(II) and copper(II) complexes of prodigiosin (1) have been characterized. All N-atoms of 1 bind Cu(II) to generate 5:  the complex exhibits regiospecific…”
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Copper-Mediated Nuclease Activity of a Tambjamine Alkaloid by Borah, Sumit, Melvin, Matt S, Lindquist, Niels, Manderville, Richard A

“…The marine natural product tambjamine E (5) has been found to efficiently bind DNA and carry out DNA cleavage in the presence of Cu(II) and molecular oxygen…”
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DNA Binding by 4-Methoxypyrrolic Natural Products. Preference for Intercalation at AT Sites by Tambjamine E and Prodigiosin by Melvin, Matt S, Ferguson, David C, Lindquist, Neils, Manderville, Richard A

“…The 4-methoxypyrrolic natural products contain a common 4-methoxy-2,2‘-bipyrrole chromophore and exhibit promising anticancer, antimicrobial, and…”
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Influence of the A-Ring on the Redox and Nuclease Properties of the Prodigiosins:  Importance of the Bipyrrole Moiety in Oxidative DNA Cleavage by Melvin, Matt S, Calcutt, M. Wade, Noftle, Ronald E, Manderville, Richard A

“…Prodigiosin (Prod, 1) is the parent member of a class of polypyrrole natural products that exhibit promising immunosuppressive and cytotoxic activity. They can…”
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N-Substituted 4β-Methyl-5-(3-hydroxyphenyl)-7α-amidomorphans Are Potent, Selective κ Opioid Receptor Antagonists by Carroll, F. Ivy, Melvin, Matt S, Nuckols, Michel C, Mascarella, S. Wayne, Navarro, Hernán A, Thomas, James B

“…In a previous study, we identified…”
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Influence of the A-Ring on the Proton Affinity and Anticancer Properties of the Prodigiosins by Melvin, Matt S, Tomlinson, John T, Park, Gyungse, Day, Cynthia S, Saluta, Gilda R, Kucera, Gregory L, Manderville, Richard A

“…Prodigiosin (Prod, 1) is the parent member of a class of polypyrrole natural products that exhibit promising immunosuppressive and anticancer activities. They…”
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Copper-nuclease efficiency correlates with cytotoxicity for the 4-methoxypyrrolic natural products by Melvin, Matt S, Wooton, Katie E, Rich, Cassandra C, Saluta, Gilda R, Kucera, Gregory L, Lindquist, Niels, Manderville, Richard A

“…The DNA-targeting activities of the 4-methoxypyrrolic natural products, that include prodigiosin ( 1), tambjamine E ( 2), and the blue pigment ( 3), have been…”
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The Causes and Consequences of the Federal Student Financial Aid Policy Shift from Grants to Loans by Melvin, Matt, Stick, Sheldon

“…Discusses the history of student financial aid's emergence as a major issue in American education, including why a policy of financial assistance was…”
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Structure–Activity Studies of 7‑Heteroaryl-3-azabicyclo[3.3.1]non-6-enes: A Novel Class of Highly Potent Nicotinic Receptor Ligands by Breining, Scott R, Melvin, Matt, Bhatti, Balwinder S, Byrd, Gary D, Kiser, Melanie N, Hepler, Christopher D, Hooker, Dawn N, Zhang, Jenny, Reynolds, Leslie A, Benson, Lisa R, Fedorov, Nikolai B, Sidach, Serguei S, Mitchener, J. Pike, Lucero, Linda M, Lukas, Ronald J, Whiteaker, Paul, Yohannes, Daniel

“…The potential for nicotinic ligands with affinity for the α4β2 or α7 subtypes to treat such diverse diseases as nicotine addiction, neuropathic pain, and…”
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N-substituted 4beta-methyl-5-(3-hydroxyphenyl)-7alpha-amidomorphans are potent, selective kappa opioid receptor antagonists by Carroll, F Ivy, Melvin, Matt S, Nuckols, Michel C, Mascarella, S Wayne, Navarro, Hernán A, Thomas, James B

“…In a previous study, we identified…”
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DNA interactions of the 4-methoxy-2,2'-bipyrrole natural products: Binding, cleavage, and structure-activity relationships by Melvin, Matt S

“…The 4-methoxy-2,2′-bipyrroles (4MOBP) are a class of natural products that exhibit a wide range of biological activity including antitumor and…”
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