Modulation of Non-alcoholic Fatty Liver Disease by Exercise
Non-alcoholic fatty liver disease (NAFLD) affects up to one-third of the population in the western countries. Diet is the major cause related to NAFLD, however other factors including lack of exercise, genetic predisposition and metabolic sexual dimorphism could also be associated with the disease....
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| Format: | Dissertation |
| Language: | English |
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ProQuest Dissertations & Theses
01-01-2021
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| Online Access: | Get full text |
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| Summary: | Non-alcoholic fatty liver disease (NAFLD) affects up to one-third of the population in the western countries. Diet is the major cause related to NAFLD, however other factors including lack of exercise, genetic predisposition and metabolic sexual dimorphism could also be associated with the disease. Therefore, chronic endurance exercise and change in diet are therapeutic strategies in the treatment of NAFLD. Metabolic, cardiorespiratory, and endocrine pathways targeted by chronic endurance exercise have been widely identified in literature, however, the liver cellular and molecular pathways modified by exercise remain unresolved. On top of exercise, the role of diet has been well documented in the initiation and progression of NAFLD. Hepatocytes absorb fatty acids proportional to their concentration in the blood. An overabundance of saturated fats, sugars and cholesterol in the diet may lead to the steatosis in the liver, and so change of diet is essential. Given that, these studies show how the transcription of hepatic genes related to metabolic disease and steatosis can be modified by chronic exercise in both male and female mice, exploring the hepatic gene expression differences between female and male mice, in addition to exploring the potential of using exercise by itself and combined with change of diet as a treatment to NAFLD. |
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| ISBN: | 9798516919701 |