Search Results - "Melo, Marcos F Vidal"
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Intraoperative protective mechanical ventilation and risk of postoperative respiratory complications: hospital based registry study
Published in BMJ (Online) (14-07-2015)“…Objective To evaluate the effects of intraoperative protective ventilation on major postoperative respiratory complications and to define safe intraoperative…”
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2
Deterioration of Regional Lung Strain and Inflammation during Early Lung Injury
Published in American journal of respiratory and critical care medicine (01-10-2018)“…The contribution of aeration heterogeneity to lung injury during early mechanical ventilation of uninjured lungs is unknown. To test the hypotheses that a…”
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3
High Positive End-Expiratory Pressure Renders Spontaneous Effort Noninjurious
Published in American journal of respiratory and critical care medicine (15-05-2018)“…In acute respiratory distress syndrome (ARDS), atelectatic solid-like lung tissue impairs transmission of negative swings in pleural pressure (Ppl) that result…”
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4
Neuroinflammation of the spinal cord and nerve roots in chronic radicular pain patients
Published in Pain (Amsterdam) (01-05-2018)“…Numerous preclinical studies support the role of spinal neuroimmune activation in the pathogenesis of chronic pain, and targeting glia (eg,…”
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Proteomics of lung tissue reveals differences in inflammation and alveolar-capillary barrier response between atelectasis and aerated regions
Published in Scientific reports (29-04-2022)“…Atelectasis is a frequent clinical condition, yet knowledge is limited and controversial on its biological contribution towards lung injury. We assessed the…”
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An anesthesia-centered bundle to reduce postoperative pulmonary complications: The PRIME-AIR study protocol
Published in PloS one (06-04-2023)“…Postoperative pulmonary complications (PPCs) are a major cause of morbidity and mortality after open abdominal surgery. Optimized perioperative lung expansion…”
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Effect of Local Tidal Lung Strain on Inflammation in Normal and Lipopolysaccharide-Exposed Sheep
Published in Critical care medicine (01-07-2014)“…OBJECTIVES:Regional tidal lung strain may trigger local inflammation during mechanical ventilation, particularly when additional inflammatory stimuli are…”
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Differential Effects of Intraoperative Positive End-expiratory Pressure (PEEP) on Respiratory Outcome in Major Abdominal Surgery Versus Craniotomy
Published in Annals of surgery (01-08-2016)“…In this study, we examined whether (1) positive end-expiratory pressure (PEEP) has a protective effect on the risk of major postoperative respiratory…”
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Quantitative Imaging Metrics for the Assessment of Pulmonary Pathophysiology: An Official American Thoracic Society and Fleischner Society Joint Workshop Report
Published in Annals of the American Thoracic Society (01-02-2023)“…Multiple thoracic imaging modalities have been developed to link structure to function in the diagnosis and monitoring of lung disease. Volumetric computed…”
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10
Relation between Respiratory Mechanics, Inflammation, and Survival in Experimental Mechanical Ventilation
Published in American journal of respiratory cell and molecular biology (01-02-2019)“…Low-tidal volume (Vt) ventilation might protect healthy lungs from volutrauma but lead to inflammation resulting from other mechanisms, namely alveolar…”
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11
Effects of Positive End-Expiratory Pressure and Spontaneous Breathing Activity on Regional Lung Inflammation in Experimental Acute Respiratory Distress Syndrome
Published in Critical care medicine (01-04-2019)“…OBJECTIVES:To determine the impact of positive end-expiratory pressure during mechanical ventilation with and without spontaneous breathing activity on…”
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12
Regional tidal lung strain in mechanically ventilated normal lungs
Published in Journal of applied physiology (1985) (01-12-2016)“…Parenchymal strain is a key determinant of lung injury produced by mechanical ventilation. However, imaging estimates of volumetric tidal strain (ε = regional…”
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13
Perioperative Pulmonary Atelectasis: Part II. Clinical Implications
Published in Anesthesiology (Philadelphia) (01-01-2022)“…The development of pulmonary atelectasis is common in the surgical patient. Pulmonary atelectasis can cause various degrees of gas exchange and respiratory…”
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14
Self-organized patchiness in asthma as a prelude to catastrophic shifts
Published in Nature (07-04-2005)“…Asthma is a common disease affecting an increasing number of children throughout the world. In asthma, pulmonary airways narrow in response to contraction of…”
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15
Perioperative Pulmonary Atelectasis: Part I. Biology and Mechanisms
Published in Anesthesiology (Philadelphia) (01-01-2022)“…Pulmonary atelectasis is common in the perioperative period. Physiologically, it is produced when collapsing forces derived from positive pleural pressure and…”
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16
Effect of regional lung inflation on ventilation heterogeneity at different length scales during mechanical ventilation of normal sheep lungs
Published in Journal of applied physiology (1985) (15-09-2012)“…Heterogeneous, small-airway diameters and alveolar derecruitment in poorly aerated regions of normal lungs could produce ventilation heterogeneity at those…”
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17
Regional gas exchange and cellular metabolic activity in ventilator-induced lung injury
Published in Anesthesiology (Philadelphia) (01-04-2007)“…Alveolar overdistension and repetitive derecruitment-recruitment contribute to ventilator-induced lung injury (VILI). The authors investigated (1) whether…”
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Temporal trends and current practice patterns for intraoperative ventilation at U.S. academic medical centers: a retrospective study
Published in BMC anesthesiology (28-03-2015)“…Lung protective ventilation strategies utilizing lower tidal volumes per predicted body weight (PBW) and positive end-expiratory pressure (PEEP) have been…”
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19
Ability of dynamic airway pressure curve profile and elastance for positive end-expiratory pressure titration
Published in Intensive care medicine (01-12-2008)“…Objective To evaluate the ability of three indices derived from the airway pressure curve for titrating positive end-expiratory pressure (PEEP) to minimize…”
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Mild Endotoxemia during Mechanical Ventilation Produces Spatially Heterogeneous Pulmonary Neutrophilic Inflammation in Sheep
Published in Anesthesiology (Philadelphia) (01-03-2010)“…There is limited information on the regional inflammatory effects of mechanical ventilation and endotoxemia on the production of acute lung injury. Measurement…”
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