Search Results - "Melo, Manuel N"

Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy by Uytterhoeven, Valerie, Lauwers, Elsa, Maes, Ine, Miskiewicz, Katarzyna, Melo, Manuel N., Swerts, Jef, Kuenen, Sabine, Wittocx, Rafaël, Corthout, Nikky, Marrink, Siewert-Jan, Munck, Sebastian, Verstreken, Patrik

“…Synapses are often far from their cell bodies and must largely independently cope with dysfunctional proteins resulting from synaptic activity and stress. To…”
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Ceramides bind VDAC2 to trigger mitochondrial apoptosis by Dadsena, Shashank, Bockelmann, Svenja, Mina, John G. M., Hassan, Dina G., Korneev, Sergei, Razzera, Guilherme, Jahn, Helene, Niekamp, Patrick, Müller, Dagmar, Schneider, Markus, Tafesse, Fikadu G., Marrink, Siewert J., Melo, Manuel N., Holthuis, Joost C. M.

“…Ceramides draw wide attention as tumor suppressor lipids that act directly on mitochondria to trigger apoptotic cell death. However, molecular details of the…”
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Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations by Castanho, Miguel A. R. B, Melo, Manuel N, Ferre, Rafael

“…Our understanding of the relationship between molecular properties of antimicrobial peptides and macroscopic effects on bacterial membranes remains limited. In…”
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Exchange pathways of plastoquinone and plastoquinol in the photosystem II complex by Van Eerden, Floris J., Melo, Manuel N., Frederix, Pim W. J. M., Periole, Xavier, Marrink, Siewert J.

“…Plastoquinone (PLQ) acts as an electron carrier between photosystem II (PSII) and the cytochrome b 6 f complex. To understand how PLQ enters and leaves PSII,…”
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Lipid unsaturation promotes BAX and BAK pore activity during apoptosis by Dadsena, Shashank, Cuevas Arenas, Rodrigo, Vieira, Gonçalo, Brodesser, Susanne, Melo, Manuel N., García-Sáez, Ana J.

“…BAX and BAK are proapoptotic members of the BCL2 family that directly mediate mitochondrial outer membrane permeabilition (MOMP), a central step in apoptosis…”
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Lipid–Protein Interactions Are Unique Fingerprints for Membrane Proteins by Corradi, Valentina, Mendez-Villuendas, Eduardo, Ingólfsson, Helgi I, Gu, Ruo-Xu, Siuda, Iwona, Melo, Manuel N, Moussatova, Anastassiia, DeGagné, Lucien J, Sejdiu, Besian I, Singh, Gurpreet, Wassenaar, Tsjerk A, Delgado Magnero, Karelia, Marrink, Siewert J, Tieleman, D. Peter

“…Cell membranes contain hundreds of different proteins and lipids in an asymmetric arrangement. Our current understanding of the detailed organization of cell…”
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A sporulation signature protease is required for assembly of the spore surface layers, germination and host colonization in Clostridioides difficile by Marini, Eleonora, Olivença, Carmen, Ramalhete, Sara, Aguirre, Andrea Martinez, Ingle, Patrick, Melo, Manuel N, Antunes, Wilson, Minton, Nigel P, Hernandez, Guillem, Cordeiro, Tiago N, Sorg, Joseph A, Serrano, Mónica, Henriques, Adriano O

“…A genomic signature for endosporulation includes a gene coding for a protease, YabG, which in the model organism Bacillus subtilis is involved in assembly of…”
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Temperature‐dependent re‐alignment of the short multifunctional peptide BP100 in membranes revealed by solid‐state NMR spectroscopy and molecular dynamics simulations by Strandberg, Erik, Wadhwani, Parvesh, Bürck, Jochen, Anders, Patrick, Mink, Christian, van den Berg, Jonas, Ciriello, Raffaele A. M., de Sousa Pereira Simões de Melo, Manuel Nuno, Castanho, Miguel, Bardají, Eduard, Ulmschneider, Jakob P., Ulrich, Anne S.

“…© 2022 The Authors. ChemBioChem published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which…”
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Localization Preference of Antimicrobial Peptides on Liquid-Disordered Membrane Domains by Su, Juanjuan, Marrink, Siewert J., Melo, Manuel N.

“…We performed coarse-grained simulations of the antimicrobial peptides Magainin-2, BP100, MSI-103, and MSI-78 on a phase-separated membrane to study their…”
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Bacteriocin AS-48 binding to model membranes and pore formation as revealed by coarse-grained simulations by Cruz, Victor L., Ramos, Javier, Melo, Manuel N., Martinez-Salazar, Javier

“…Bacteriocin AS-48 is a membrane-interacting peptide that acts as a broad-spectrum antimicrobial against Gram-positive and Gram-negative bacteria. Prior Nuclear…”
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Studies on the Interaction between Model Proteins and Fluorinated Ionic Liquids by Alves, Márcia M S, Melo, Manuel N, Mertens, Haydyn D T, Pereiro, Ana B, Archer, Margarida

“…Proteins are inherently unstable, which limits their use as therapeutic agents. However, the use of biocompatible cosolvents or surfactants can help to…”
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Overlapping properties of the short membrane-active peptide BP100 with (i) Polycationic TAT and (ii) α-helical Magainin Family Peptides by Mink, Christian, Strandberg, Erik, Wadhwani, Parvesh, de Sousa Pereira Simões de Melo, Manuel Nuno, Reichert, Johannes, Wacker, Irene, Castanho, Miguel, Ulrich, Anne S.

“…Copyright © 2021 Mink, Strandberg, Wadhwani, Melo, Reichert, Wacker, Castanho and Ulrich. This is an open-access article distributed under the terms of the…”
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Rotation of the c ‐Ring Promotes the Curvature Sorting of Monomeric ATP Synthases by Valdivieso González, David, Makowski, Marcin, Lillo, M. Pilar, Cao‐García, Francisco J., Melo, Manuel N., Almendro‐Vedia, Víctor G., López‐Montero, Iván

“…Abstract ATP synthases are proteins that catalyse the formation of ATP through the rotatory movement of their membrane‐spanning subunit. In mitochondria, ATP…”
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SARS-CoV-2 variants impact RBD conformational dynamics and ACE2 accessibility by Valério, Mariana, Borges-Araújo, Luís, Melo, Manuel N, Lousa, Diana, Soares, Cláudio M

“…Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has killed over 6 million people and is having…”
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Xport-A functions as a chaperone by stabilizing the first five transmembrane domains of rhodopsin-1 by Gaspar, Catarina J., Gomes, Tiago, Martins, Joana C., Melo, Manuel N., Adrain, Colin, Cordeiro, Tiago N., Domingos, Pedro M.

“…Rhodopsin-1 (Rh1), the main photosensitive protein of Drosophila, is a seven-transmembrane domain protein, which is inserted co-translationally in the…”
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Prediction of antibacterial activity from physicochemical properties of antimicrobial peptides by Melo, Manuel N, Ferre, Rafael, Feliu, Lídia, Bardají, Eduard, Planas, Marta, Castanho, Miguel A R B

“…Consensus is gathering that antimicrobial peptides that exert their antibacterial action at the membrane level must reach a local concentration threshold to…”
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Activity modulation of the Escherichia coli F1FO ATP synthase by a designed antimicrobial peptide via cardiolipin sequestering by Makowski, Marcin, Almendro-Vedia, Víctor G., Domingues, Marco M., Franco, Octavio L., López-Montero, Iván, Melo, Manuel N., Santos, Nuno C.

“…Most antimicrobial peptides (AMPs) exert their microbicidal activity through membrane permeabilization. The designed AMP EcDBS1R4 has a cryptic mechanism of…”
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Coarse-Grain Simulations of Membrane-Adsorbed Helical Peptides by Melo, Manuel N

“…The amphipathic α-helix is a common motif for peptide adsorption to membranes. Many physiologically relevant events involving membrane-adsorbed peptides occur…”
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Acyl-chain saturation regulates the order of phosphatidylinositol 4,5-bisphosphate nanodomains by Borges-Araújo, Luís, Domingues, Marco M., Fedorov, Alexander, Santos, Nuno C., Melo, Manuel N., Fernandes, Fábio

“…Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P 2 ) plays a critical role in the regulation of various plasma membrane processes and signaling pathways in…”
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The Mechanism of Action of Antimicrobial Peptides: Lipid Vesicles vs. Bacteria by Melo, Manuel N, Castanho, Miguel A R B

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