Search Results - "Melo, Luciana Garcia"

Harnessing Macrophages through the Blockage of CD47: Implications for Acute Myeloid Leukemia by Melo Garcia, Luciana, Barabé, Frédéric

“…CD47 is a surface membrane protein expressed by all normal tissues. It is the so-called "don't eat me signal" because it protects the cells against…”
Get full text

CAR‐NK cells: the next wave of cellular therapy for cancer by Daher, May, Melo Garcia, Luciana, Li, Ye, Rezvani, Katayoun

“…T cells engineered to express chimeric antigen receptors (CARs) have revolutionised the field of cellular therapy for cancer. Despite its success, this…”
Get full text

Engineered cord blood megakaryocytes evade killing by allogeneic T-cells for refractory thrombocytopenia by Kumar, Bijender, Afshar-Kharghan, Vahid, Mendt, Mayela, Sackstein, Robert, Tanner, Mark R., Popat, Uday, Ramdial, Jeremy, Daher, May, Jimenez, Juan, Basar, Rafet, Melo Garcia, Luciana, Shanley, Mayra, Kaplan, Mecit, Wan, Xinhai, Nandivada, Vandana, Reyes Silva, Francia, Woods, Vernikka, Gilbert, April, Gonzalez-Delgado, Ricardo, Acharya, Sunil, Lin, Paul, Rafei, Hind, Banerjee, Pinaki Prosad, Shpall, Elizabeth J.

“…The current global platelet supply is often insufficient to meet all the transfusion needs of patients, in particular for those with alloimmune…”
Get full text

KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape by Li, Ye, Basar, Rafet, Wang, Guohui, Liu, Enli, Moyes, Judy S., Li, Li, Kerbauy, Lucila N., Uprety, Nadima, Fathi, Mohsen, Rezvan, Ali, Banerjee, Pinaki P., Muniz-Feliciano, Luis, Laskowski, Tamara J., Ensley, Emily, Daher, May, Shanley, Mayra, Mendt, Mayela, Acharya, Sunil, Liu, Bin, Biederstädt, Alexander, Rafei, Hind, Guo, Xingliang, Melo Garcia, Luciana, Lin, Paul, Ang, Sonny, Marin, David, Chen, Ken, Bover, Laura, Champlin, Richard E., Varadarajan, Navin, Shpall, Elizabeth J., Rezvani, Katayoun

“…Trogocytosis is an active process that transfers surface material from targeted to effector cells. Using multiple in vivo tumor models and clinical data, we…”
Get full text

Combining AFM13, a Bispecific CD30/CD16 Antibody, with Cytokine-Activated Blood and Cord Blood-Derived NK Cells Facilitates CAR-like Responses Against CD30 + Malignancies by Kerbauy, Lucila N, Marin, Nancy D, Kaplan, Mecit, Banerjee, Pinaki P, Berrien-Elliott, Melissa M, Becker-Hapak, Michelle, Basar, Rafet, Foster, Mark, Garcia Melo, Luciana, Neal, Carly C, McClain, Ethan, Daher, May, Nunez Cortes, Ana Karen, Desai, Sweta, Inng Lim, Francesca Wei, Mendt, Mayela Carolina, Schappe, Timothy, Li, Li, Shaim, Hila, Shanley, Mayra, Ensley, Emily L, Uprety, Nadima, Wong, Pamela, Liu, Enli, Ang, Sonny O, Cai, Rong, Nandivada, Vandana, Mohanty, Vakul, Miao, Qi, Shen, Yifei, Baran, Natalia, Fowlkes, Natalie W, Chen, Ken, Muniz-Feliciano, Luis, Champlin, Richard E, Nieto, Yago L, Koch, Joachim, Treder, Martin, Fischer, Wolfgang, Okamoto, Oswaldo Keith, Shpall, Elizabeth J, Fehniger, Todd A, Rezvani, Katayoun

“…Natural killer (NK)-cell recognition and function against NK-resistant cancers remain substantial barriers to the broad application of NK-cell immunotherapy…”
Get full text

Generation of glucocorticoid-resistant SARS-CoV-2 T cells for adoptive cell therapy by Basar, Rafet, Uprety, Nadima, Ensley, Emily, Daher, May, Klein, Kimberly, Martinez, Fernando, Aung, Fleur, Shanley, Mayra, Hu, Bingqian, Gokdemir, Elif, Nunez Cortes, Ana Karen, Mendt, Mayela, Reyes Silva, Francia, Acharya, Sunil, Laskowski, Tamara, Muniz-Feliciano, Luis, Banerjee, Pinaki P., Li, Ye, Li, Sufang, Melo Garcia, Luciana, Lin, Paul, Shaim, Hila, Yates, Sean G., Marin, David, Kaur, Indreshpal, Rao, Sheetal, Mak, Duncan, Lin, Angelique, Miao, Qi, Dou, Jinzhuang, Chen, Ken, Champlin, Richard E., Shpall, Elizabeth J., Rezvani, Katayoun

“…Adoptive cell therapy with virus-specific T cells has been used successfully to treat life-threatening viral infections, supporting application of this…”
Get full text

Navigating the Immunological Crossroads: Mesenchymal Stem/Stromal Cells as Architects of Inflammatory Harmony in Tissue-Engineered Constructs by Farzamfar, Saeed, Garcia, Luciana Melo, Rahmani, Mahya, Bolduc, Stephane

“…In the dynamic landscape of tissue engineering, the integration of tissue-engineered constructs (TECs) faces a dual challenge-initiating beneficial…”
Get full text

Abstracts of the Cell Therapy Transplant Canada 2023 Annual Conference by Maier, Stephanie A, Ahmad, Imran, Berg, Tobias, Berrigan, Susan, Elsawy, Mahmoud, Garcia-Horton, Alejandro, Lam, Wilson, Lapworth, Alix, Melo Garcia, Luciana, Shah, Ravi M, Vasudevan Nampoothiri, Ram, Delisle, Jean-Sébastien

“…On behalf of Cell Therapy Transplant Canada (CTTC), we are pleased to present the Abstracts of the CTTC 2023 Annual Conference. The conference was held…”
Get full text

Metabolic Reprogramming of GMP Grade Cord Tissue Derived Mesenchymal Stem Cells Enhances Their Suppressive Potential in GVHD by Mendt, Mayela, Daher, May, Basar, Rafet, Shanley, Mayra, Kumar, Bijender, Wei Inng, Francesca Lim, Acharya, Sunil, Shaim, Hila, Fowlkes, Natalie, Tran, Jamie P, Gokdemir, Elif, Uprety, Nadima, Nunez-Cortes, Ana K, Ensley, Emily, Mai, Thao, Kerbauy, Lucila N, Melo-Garcia, Luciana, Lin, Paul, Shen, Yifei, Mohanty, Vakul, Lu, JunJun, Li, Sufang, Nandivada, Vandana, Wang, Jing, Banerjee, Pinaki, Reyes-Silva, Francia, Liu, Enli, Ang, Sonny, Gilbert, April, Li, Ye, Wan, Xinhai, Gu, Jun, Zhao, Ming, Baran, Natalia, Muniz-Feliciano, Luis, Wilson, Jeffrey, Kaur, Indreshpal, Gagea, Mihai, Konopleva, Marina, Marin, David, Tang, Guilin, Chen, Ken, Champlin, Richard, Rezvani, Katayoun, Shpall, Elizabeth J

“…Acute graft-vs.-host (GVHD) disease remains a common complication of allogeneic stem cell transplantation with very poor outcomes once the disease becomes…”
Get full text

Abstracts of the Cell Therapy Transplant Canada 2022 Annual Conference by Maier, Stephanie A, Berg, Tobias, Berrigan, Susan, Bramson, Jonathan, Bredeson, Chris, Cantin, Guy, Daly, Andrew, Davies, Gwynivere A, Elsawy, Mahmoud, Garcia-Horton, Alejandro, Lam, Wilson, Lapworth, Alix, Lepic, Kylie, Melo Garcia, Luciana, Schultz, Kirk R, Vasudevan Nampoothiri, Ram, White, Darrell, Delisle, Jean-Sébastien

“…On behalf of Cell Therapy Transplant Canada (CTTC), we are pleased to present the Abstracts of the CTTC 2022 Annual Conference. The conference was held…”
Get full text

531 AFM13-targeted blood and cord-blood-derived memory-like NK cells as therapy for CD30+ malignancies by Kerbauy, Lucila, Marin, Nancy, Kaplan, Mecit, Banerjee, Pinaki, Berrien-Elliott, Melissa, Becker-Hapak, Michelle, Basar, Rafet, Foster, Mark, Melo, Luciana Garcia, Neal, Carly, McClain, Ethan, Daher, May, Nunez Cortes, Ana Karen, Desai, Sweta, Inng Lim, Francesca Wei, Mendt, Mayela Carolina, Schappe, Timothy, Li, Li, Shaim, Hila, Sanabria, Mayra Hernandez, Wong, Pamela, Liu, Enli, Ang, Sonny, Cai, Rong, Nandivada, Vandana, Mohanty, Vakul, Shen, Yifei, Baran, Natalia, Fowlkes, Natalie, Chen, Ken, Muniz-Feliciano, Luis, Koch, Joachim, Treder, Martin, Fischer, Wolfgang, Okamoto, Oswaldo Keith, Nieto, Yago, Champlin, Richard, Shpall, Elizabeth, Fehniger, Todd, Rezvani, Katy

“…BackgroundNatural killer (NK) cells are a nascent cellular immunotherapy for hematologic malignancies. Target recognition of NK cell-resistant cancers remains…”
Get full text

Mapping Expressive Differences Around the World: The Relationship Between Emotional Display Rules and Individualism Versus Collectivism by Matsumoto, David, Seung Hee Yoo, Fontaine, Johnny

“…Despite the importance of the concept of cultural display rules in explaining cultural differences in emotional expression and despite the fact that it has…”
Get full text

Chimeric Antigen Receptor-Engineered NK Cells Overcome CD226 Downregulation As an Immune Escape Mechanism in Acute Myeloid Leukemia by Melo Garcia, Luciana, Gangadharan, Achintyan, Banerjee, Pinaki, Lin, Paul, Daher, MD, May, Rafei, Hind, Kumar, Bijender, Rezvani, Katayoun

“…Background: Natural killer (NK) cells are part of the innate immune system, and their killing capacity depends on the inputs from activating and inhibitory…”
Get full text

Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia by Baran, Natalia, Lodi, Alessia, Dhungana, Yogesh, Herbrich, Shelley, Collins, Meghan, Sweeney, Shannon, Pandey, Renu, Skwarska, Anna, Patel, Shraddha, Tremblay, Mathieu, Kuruvilla, Vinitha Mary, Cavazos, Antonio, Kaplan, Mecit, Warmoes, Marc O., Veiga, Diogo Troggian, Furudate, Ken, Rojas-Sutterin, Shanti, Haman, Andre, Gareau, Yves, Marinier, Anne, Ma, Helen, Harutyunyan, Karine, Daher, May, Garcia, Luciana Melo, Al-Atrash, Gheath, Piya, Sujan, Ruvolo, Vivian, Yang, Wentao, Shanmugavelandy, Sriram Saravanan, Feng, Ningping, Gay, Jason, Du, Di, Yang, Jun J., Hoff, Fieke W., Kaminski, Marcin, Tomczak, Katarzyna, Eric Davis, R., Herranz, Daniel, Ferrando, Adolfo, Jabbour, Elias J., Emilia Di Francesco, M., Teachey, David T., Horton, Terzah M., Kornblau, Steven, Rezvani, Katayoun, Sauvageau, Guy, Gagea, Mihai, Andreeff, Michael, Takahashi, Koichi, Marszalek, Joseph R., Lorenzi, Philip L., Yu, Jiyang, Tiziani, Stefano, Hoang, Trang, Konopleva, Marina

“…T-cell acute lymphoblastic leukemia (T-ALL) is commonly driven by activating mutations in NOTCH1 that facilitate glutamine oxidation. Here we identify…”
Get full text

NK Cell Dysfunction in CLL Is Mediated through SHP-1 Signaling and Is Associated with Poor Prognosis by Shaim, Hila, Rafei, Hind, Kaplan, Mecit, Basar, Rafet, Daher, MD, May, Shanley, Mayra, Banerjee, Pinaki, Kumar, Bijender, Nunez Cortes, Ana K., Islam, Sanjida, Jiang, Xin Ru, Kerbauy, Lucila Nassif, Lin, Paul, Gokdemir, Elif, Uprety, Nadima, Acharya, Sunil, Mendt, Mayela Carolina, Melo Garcia, Luciana, Biederstädt, Alexander, Liu, Bin, Liu, Enli, Ang, Sonny, Burger, Jan A., Wierda, William G., Ferrajoli, Alessandra, Shpall, Elizabeth J., Rezvani, Katayoun

“…Chronic lymphocytic leukemia (CLL) is a heterogeneous disease, presenting with a highly variable clinical course, outcome and response to therapy. This…”
Get full text

CD70 CAR NK Cells in the Treatment of Multiple Myeloma by Lin, Paul, Reyes Silva, Francia C., Lin, Pei, Gilbert, April L., Acharya, Sunil, Nunez Cortes, Ana K., Banerjee, Pinaki, Fang, Dexing, Melo Garcia, Luciana, Daher, MD, May, Basar, Rafet, Patel, Krina K., Lee, Hans C., Orlowski, Robert Z., Rafei, Hind, Marin, David, Champlin, Richard E., Shpall, Elizabeth J., Rezvani, Katayoun

“…Despite the high response rates of chimeric antigen receptor (CAR) - T cells targeting the B-cell maturation antigen (BCMA) for multiple myeloma (MM), patients…”
Get full text

Generation and Screening of Various CD70 CAR NK Cells Identify the Most Effective Construct Against Hematologic Malignancies by Acharya, Sunil, Basar, Rafet, Daher, MD, May, Li, Ping, Rafei, Hind, Uprety, Nadima, Ensley, Emily, Shanley, Mayra, Kumar, Bijender, Banerjee, Pinaki, Melo Garcia, Luciana, Lin, Paul, Mohanty, Vakul, Pan, Yuchen, Miao, Qi, Kim, Kun Hee, Jiang, Xianli, Li, Ye, Liu, Bin, Nunez Cortes, Ana K., Zhang, Patrick, Fathi, Mohsen, Rezvan, Ali, Montalvo, Melisa J, Liu, Enli, Varadarajan, Navin, Chen, Ken, Marin, David, Champlin, Richard E., Shpall, Elizabeth J., Rezvani, Katayoun

“…The ability to re-direct the intrinsic power of the immune system against cancer has resulted in unprecedented outcomes in certain patients with otherwise…”
Get full text

Targeting T-Cell Lymphoma Using CD70-Directed Cord Blood-Derived CAR-NK Cells by Rafei, Hind, Basar, Rafet, Acharya, Sunil, Zhang, Patrick, Liu, Pinghua, Moseley, Sadie Mae, Li, Ping, Daher, MD, May, Agarwal, Nitin, Marques-Piubelli, Mario L., Uprety, Nadima, Melo Garcia, Luciana, Shanley, Mayra, Banerjee, Pinaki, Li, Ye, Rosemore, Samuel Levi, Kumar, Bijender, Nunez Cortes, Ana K., Biederstädt, Alexander, Islam, Sanjida, Kaplan, Mecit, Hu, Bingqian, Manzar, Gohar, Lin, Paul, Marin, David, Champlin, Richard E., Vega, Francisco, Shpall, Elizabeth J., Rezvani, Katayoun

“…T-cell lymphomas (TCL) are a heterogenous group of non-Hodgkin lymphoma characterized by resistance to conventional therapies posing an urgent need for safe…”
Get full text

Author Correction: KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape by Li, Ye, Basar, Rafet, Wang, Guohui, Liu, Enli, Moyes, Judy S., Li, Li, Kerbauy, Lucila N., Uprety, Nadima, Fathi, Mohsen, Rezvan, Ali, Banerjee, Pinaki P., Muniz-Feliciano, Luis, Laskowski, Tamara J., Ensley, Emily, Daher, May, Shanley, Mayra, Mendt, Mayela, Acharya, Sunil, Liu, Bin, Biederstädt, Alexander, Rafei, Hind, Guo, Xingliang, Melo Garcia, Luciana, Lin, Paul, Ang, Sonny, Marin, David, Chen, Ken, Bover, Laura, Champlin, Richard E., Varadarajan, Navin, Shpall, Elizabeth J., Rezvani, Katayoun

Get full text

Epigenetic Scarring Leads to Irreversible NK Cell Dysfunction in Myeloid Malignancies by Kumar, Bijender, Singh, Anand, Basar, Rafet, Uprety, Nadima, Li, Ye, Fan, Huihui, Shanley, Mayra, Acharya, Sunil, Mendt, Mayela Carolina, Lin, Paul, Biederstädt, Alexander, Rafei, Hind, Banerjee, Pinaki, Mohanty, Vakul, Shaim, Hila, Dede, Merve, Melo Garcia, Luciana, Kerbauy, Lucila Nassif, Nunez Cortes, Ana K., Miao, Qi, Dou, Jinzhuang, Silva Reyes, Francia, Guo, Xingliang, Kaplan, Mecit, Ang, Sonny, Jiang, Xin Ru, Liu, Enli, Liu, Bin, Champlin, Richard E., Kantarjian, Hagop, Marin, David, Chen, Ken, Abbas, Hussein A, Shpall, Elizabeth J., Rai, Kunal, Rezvani, Katayoun, Daher, MD, May

“…Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) belong to the same spectrum of myeloid malignancies and have extremely poor outcomes in the…”
Get full text