Search Results - "Melo, Fabio R."

Mast Cell Proteoglycans by Rönnberg, Elin, Melo, Fabio R., Pejler, Gunnar

“…Mast cells are versatile effector cells of the immune system, contributing to both innate and adaptive immunity toward pathogens but also having profound…”
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Tryptase-catalyzed core histone truncation: a novel epigenetic regulatory mechanism in mast cells by Melo, Fabio R., PhD, Wallerman, Ola, PhD, Paivandy, Aida, MSc, Calounova, Gabriela, PhD, Gustafson, Ann-Marie, Ms, Sabari, Benjamin R., PhD, Zabucchi, Giuliano, PhD, Allis, C David, PhD, Pejler, Gunnar, PhD

“…Abstract Background Mast cells are key effector cells in allergic reactions. When activated to degranulate, they release a plethora of bioactive compounds from…”
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Slight differences in sulfation of algal galactans account for differences in their anticoagulant and venous antithrombotic activities by Fonseca, Roberto J C, Oliveira, Stephan-Nicollas M C G, Melo, Fábio R, Pereira, Maria G, Benevides, Norma M B, Mourão, Paulo A S

“…We compared sulfated galactans (SGs) from two species of red algae using specific coagulation assays and experimental models of thrombosis. These…”
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Mitogen-Activated Protein Kinase Signaling Regulates Proteoglycan Composition of Mast Cell Secretory Granules by Hu Frisk, Jun Mei, Kjellén, Lena, Melo, Fabio R, Öhrvik, Helena, Pejler, Gunnar

“…Mast cells (MCs) are characterized by an abundance of lysosome-like secretory granules filled with immunomodulatory compounds including histamine, cytokines,…”
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Induction of Human Lung Mast Cell Apoptosis by Granule Permeabilization: A Novel Approach for Targeting Mast Cells by Paivandy, Aida, Sandelin, Martin, Igelström, Helena, Landelius, Per, Janson, Christer, Melo, Fabio R, Pejler, Gunnar

“…Mast cells are implicated as detrimental players in inflammatory lung diseases, particularly asthma. Mast cells respond to activating stimuli by releasing a…”
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An algal sulfated galactan has an unusual dual effect on venous thrombosis due to activation of factor XII and inhibition of the coagulation proteases by Melo, Fábio R, Mourão, Paulo A S

“…Sulfated galactan from the red alga Botryocladia occidentalis has a potent anticoagulant activity, due to its ability to enhance thrombin and factor Xa…”
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Nuclear receptor 4a3 (nr4a3) regulates murine mast cell responses and granule content by Garcia-Faroldi, Gianni, Melo, Fabio R, Bruemmer, Dennis, Conneely, Orla M, Pejler, Gunnar, Lundequist, Anders

“…Nuclear receptor 4a3 (Nr4a3) is a transcription factor implicated in various settings such as vascular biology and inflammation. We have recently shown that…”
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Anticoagulant activity of a sulfated galactan: serpin-independent effect and specific interaction with factor Xa by Glauser, Bianca F, Rezende, Ricardo M, Melo, Fabio R, Pereira, Mariana S, Francischetti, Ivo M B, Monteiro, Robson Q, Rezaie, Alireza R, Mourão, Paulo A S

“…An algal sulfated galactan has high anticoagulant and antithrombotic activities. Its serpin-dependent anticoagulant action is due to promoting thrombin and…”
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Proteolytic Histone Modification by Mast Cell Tryptase, a Serglycin Proteoglycan-dependent Secretory Granule Protease by Melo, Fabio R., Vita, Francesca, Berent-Maoz, Beata, Levi-Schaffer, Francesca, Zabucchi, Giuliano, Pejler, Gunnar

“…A hallmark feature of mast cells is their high content of cytoplasmic secretory granules filled with various preformed compounds, including proteases of…”
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Active caspase-3 is stored within secretory compartments of viable mast cells by Garcia-Faroldi, Gianni, Melo, Fabio R, Rönnberg, Elin, Grujic, Mirjana, Pejler, Gunnar

“…Caspase-3 is a main executioner of apoptotic cell death. The general notion is that, in viable cells, caspase-3 is found as a cytosolic inactive proenzyme and…”
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Structural composition and differential anticoagulant activities of dermatan sulfates from the skin of four species of rays, Dasyatis americana, Dasyatis gutatta, Aetobatus narinari and Potamotrygon motoro by Dellias, João M.M., Onofre, Glaucia R., Werneck, Cláudio C., Landeira-Fernandez, Ana M., Melo, Fabio R., Farias, Wladimir R.L., Silva, Luiz-Claudio F.

“…We compared the disaccharide composition of dermatan sulfate (DS) purified from the ventral skin of three species of rays from the Brazilian seacoast, Dasyatis…”
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Induction of mast cell apoptosis by a novel secretory granule-mediated pathway by Melo, Fabio R, Wernersson, Sara, Pejler, Gunnar

“…Mast cells (MCs) have detrimental functions in the context of numerous pathologies, and regimens aimed at neutralizing MCs or individual MC products can thus…”
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Serglycin Proteoglycan Promotes Apoptotic versus Necrotic Cell Death in Mast Cells by Melo, Fabio R., Grujic, Mirjana, Spirkoski, Jane, Calounova, Gabriela, Pejler, Gunnar

“…The mechanisms that govern whether a cell dies by apoptosis or necrosis are not fully understood. Here we show that serglycin, a secretory granule proteoglycan…”
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Mast cell apoptosis induced by siramesine, a sigma-2 receptor agonist by Spirkoski, Jane, Melo, Fabio R., Grujic, Mirjana, Calounova, Gabriela, Lundequist, Anders, Wernersson, Sara, Pejler, Gunnar

“…Mast cells (MCs) are well known for their detrimental effects in the context of allergic disorders. Strategies that limit MC function can therefore have a…”
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Ablation of human skin mast cells in situ by lysosomotropic agents by Hagforsen, Eva, Paivandy, Aida, Lampinen, Maria, Weström, Simone, Calounova, Gabriela, Melo, Fabio R., Rollman, Ola, Pejler, Gunnar

“…Mast cells are known to have a detrimental impact on numerous types of inflammatory skin diseases such as contact dermatitis, atopic eczema and cutaneous…”
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Damnacanthal inhibits IgE receptor-mediated activation of mast cells by Garcia-Vilas, Javier A., Medina, Miguel A., Melo, Fabio R., Pejler, Gunnar, Garcia-Faroldi, Gianni

“…•The anthraquinone damnacanthal completely inhibits mast cell degranulation upon IgE-R-cross-linking and calcium ionophore stimulation.•Damnacanthal abrogates…”
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Is there a correlation between structure and anticoagulant action of sulfated galactans and sulfated fucans? by Pereira, Mariana S., Melo, Fábio R., Mourão, Paulo A.S.

“…We attempted to identify the specific structural features in sulfated galactans and sulfated fucans that confer anticoagulant activity. For this study we…”
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Mefloquine, an anti‐malaria agent, causes reactive oxygen species‐dependent cell death in mast cells via a secretory granule‐mediated pathway by Paivandy, Aida, Calounova, Gabriela, Zarnegar, Behdad, Öhrvik, Helena, Melo, Fabio R., Pejler, Gunnar

“…Mast cells are known to have a detrimental impact on a variety of pathological conditions. There is therefore an urgent need of developing strategies that…”
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Sulfated galactan is a catalyst of antithrombin-mediated inactivation of α-thrombin by Melo, Fábio R., Pereira, Mariana S., Monteiro, Robson Q., Foguel, Débora, Mourão, Paulo A.S.

“…Novel compounds presenting anticoagulant activity, such as sulfated polysaccharides, open new perspectives in medicine. Elucidation of the molecular mechanism…”
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Structural composition and anticoagulant activity of dermatan sulfate from the skin of the electric eel, Electrophorus electricus (L.) by Souza, Maisa L.S., Dellias, João M.M., Melo, Fábio R., Silva, Luiz-Claudio F.

“…We determined the disaccharide composition of dermatan sulfate (DS) purified from the skin of the electric eel Electrophorus electricus. DS obtained from the…”
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