Search Results - "Melo, Fabiana H M"
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The promigratory activity of the matricellular protein galectin-3 depends on the activation of PI-3 kinase
Published in PloS one (28-12-2011)“…Expression of galectin-3 is associated with sarcoma progression, invasion and metastasis. Here we determined the role of extracellular galectin-3 on migration…”
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Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation
Published in Molecular cancer (25-03-2013)“…Anoikis resistance is one of the abilities acquired along tumor progression. This characteristic is associated with metastasis development, since tumorigenic…”
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Enhanced OXPHOS, glutaminolysis and β-oxidation constitute the metastatic phenotype of melanoma cells
Published in Biochemical journal (15-03-2016)“…Tumours display different cell populations with distinct metabolic phenotypes. Thus, subpopulations can adjust to different environments, particularly with…”
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Timp1 Promotes Cell Survival by Activating the PDK1 Signaling Pathway in Melanoma
Published in Cancers (21-04-2017)“…High TIMP1 expression is associated with poor prognosis in melanoma, where it can bind to CD63 and β1 integrin, inducing PI3-kinase pathway and cell survival…”
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Oxidative Stress Modulates DNA Methylation during Melanocyte Anchorage Blockade Associated with Malignant Transformation
Published in Neoplasia (New York, N.Y.) (01-12-2007)“…Both oxidative/nitrosative stress and alterations in DNA methylation are observed during carcinogenesis of different tumor types, but no clear correlation…”
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Endothelial nitric oxide synthase uncoupling as a key mediator of melanocyte malignant transformation associated with sustained stress conditions
Published in Free radical biology & medicine (15-05-2011)“…Melanoma cell lines and cells corresponding to premalignant melanocytes were established by our group after subjecting a nontumorigenic murine melanocyte…”
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Biological Applications of a Chimeric Probe for the Assessment of Galectin-3 Ligands
Published in The journal of histochemistry and cytochemistry (01-10-2007)“…β1–6 branching of N-linked oligosaccharides has been correlated with the progression of different cancers. The leukoagglutinins of Phaseolus vulgaris (L-PHA)…”
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Abstract 426: Transcriptional regulation of dnmt1 by E2F1 in melanoma progression
Published in Cancer research (Chicago, Ill.) (01-10-2014)“…Abstract Melanoma is the most aggressive skin cancer due to its high resistance to currently available therapy. Like other kinds of cancer, melanoma presents…”
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Oxidative Stress Modulates DNA Methylation during Melanocyte Anchorage Blockade Associated with Malignant Transformation1
Published in Neoplasia (New York, N.Y.) (01-12-2007)“…Both oxidative/nitrosative stress and alterations in DNA methylation are observed during carcinogenesis of different tumor types, but no clear correlation…”
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Journal Article