Search Results - "Melo, Bernardete F"

Peripheral Dopamine Directly Acts on Insulin-Sensitive Tissues to Regulate Insulin Signaling and Metabolic Function by Tavares, Gabriela, Martins, Fatima. O., Melo, Bernardete. F., Matafome, Paulo, Conde, Silvia. V.

“…Dopamine is a key regulator of glucose metabolism in the central nervous system. However, dopamine is also present in the periphery and may have direct effects…”
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Exploring the Mediators that Promote Carotid Body Dysfunction in Type 2 Diabetes and Obesity Related Syndromes by Sacramento, Joana F, Andrzejewski, Kryspin, Melo, Bernardete F, Ribeiro, Maria J, Obeso, Ana, Conde, Silvia V

“…Carotid bodies (CBs) are peripheral chemoreceptors that sense changes in blood O , CO , and pH levels. Apart from ventilatory control, these organs are deeply…”
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Long-Term Hypercaloric Diet Consumption Exacerbates Age-Induced Dysmetabolism and Carotid Body Dysfunction: Beneficial Effects of CSN Denervation by Melo, Bernardete F, Sacramento, Joana F, Capucho, Adriana M, Sampaio-Pires, Dinis, Prego, Cláudia S, Conde, Silvia V

“…Carotid bodies (CBs) are metabolic sensors whose dysfunction is involved in the genesis of dysmetabolic states. Ageing induces significant alterations in CB…”
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Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery by Melo, Bernardete F., Prieto-Lloret, Jesus, Cabral, Marlene D., Martins, Fatima O., Martins, Inês B., Sacramento, Joana F., Ruivo, Pedro, Carvalho, Tânia, Conde, Silvia V.

“…© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing,…”
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Blood Pressure Regulation by the Carotid Sinus Nerve: Clinical Implications for Carotid Body Neuromodulation by Conde, Silvia V, Sacramento, Joana F, Melo, Bernardete F, Fonseca-Pinto, Rui, Romero-Ortega, Mario I, Guarino, Maria P

“…Chronic carotid sinus nerve (CSN) electrical modulation through kilohertz frequency alternating current improves metabolic control in rat models of type 2…”
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Evaluating the Impact of Different Hypercaloric Diets on Weight Gain, Insulin Resistance, Glucose Intolerance, and its Comorbidities in Rats by Melo, Bernardete F, Sacramento, Joana F, Ribeiro, Maria J, Prego, Claudia S, Correia, Miguel C, Coelho, Joana C, Cunha-Guimaraes, Joao P, Rodrigues, Tiago, Martins, Ines B, Guarino, Maria P, Seiça, Raquel M, Matafome, Paulo, Conde, Silvia V

“…Animal experimentation has a long history in the study of metabolic syndrome-related disorders. However, no consensus exists on the best models to study these…”
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Chronic Intermittent Hypoxia Induces Early-Stage Metabolic Dysfunction Independently of Adipose Tissue Deregulation by Martins, Fátima O., Sacramento, Joana F., Olea, Elena, Melo, Bernardete F., Prieto-Lloret, Jesus, Obeso, Ana, Rocher, Asuncion, Matafome, Paulo, Monteiro, Emilia C., Conde, Silvia V.

“…Several studies demonstrated a link between obstructive sleep apnea (OSA) and the development of insulin resistance. However, the main event triggering insulin…”
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Bioelectronic modulation of carotid sinus nerve activity in the rat: a potential therapeutic approach for type 2 diabetes by Sacramento, Joana F., Chew, Daniel J., Melo, Bernardete F., Donegá, Matteo, Dopson, Wesley, Guarino, Maria P., Robinson, Alison, Prieto-Lloret, Jesus, Patel, Sonal, Holinski, Bradley J., Ramnarain, Nishan, Pikov, Victor, Famm, Kristoffer, Conde, Silvia V.

“…Aims/hypothesis A new class of treatments termed bioelectronic medicines are now emerging that aim to target individual nerve fibres or specific brain circuits…”
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Insulin resistance: a new consequence of altered carotid body chemoreflex? by Conde, Silvia V., Ribeiro, Maria J., Melo, Bernardete F., Guarino, Maria P., Sacramento, Joana F.

“…Metabolic diseases affect millions of individuals across the world and represent a group of chronic diseases of very high prevalence and relatively low…”
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High fat diet blunts the effects of leptin on ventilation and on carotid body activity by Ribeiro, Maria J., Sacramento, Joana F., Gallego‐Martin, Teresa, Olea, Elena, Melo, Bernardete F., Guarino, Maria P., Yubero, Sara, Obeso, Ana, Conde, Silvia V.

“…Key points Leptin plays a role in the control of breathing, acting mainly on central nervous system; however, leptin receptors have been recently shown to be…”
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Functional abolition of carotid body activity restores insulin action and glucose homeostasis in rats: key roles for visceral adipose tissue and the liver by Sacramento, Joana F., Ribeiro, Maria J., Rodrigues, Tiago, Olea, Elena, Melo, Bernardete F., Guarino, Maria P., Fonseca-Pinto, Rui, Ferreira, Cristiana R., Coelho, Joana, Obeso, Ana, Seiça, Raquel, Matafome, Paulo, Conde, Sílvia V.

“…Aims/hypothesis We recently described that carotid body (CB) over-activation is involved in the aetiology of insulin resistance and arterial hypertension in…”
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Contribution of adenosine and ATP to the carotid body chemosensory activity in ageing by Sacramento, Joana F., Olea, Elena, Ribeiro, Maria J., Prieto‐Lloret, Jesus, Melo, Bernardete F., Gonzalez, Constancio, Martins, Fatima O., Monteiro, Emilia C., Conde, Silvia V.

“…Key points Adenosine and ATP are excitatory neurotransmitters involved in the carotid body (CB) response to hypoxia. During ageing the CB exhibits a decline in…”
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Carotid Body Dysfunction in Diet-Induced Insulin Resistance Is Associated with Alterations in Its Morphology by Dos Santos, Eliano, Sacramento, Joana F, Melo, Bernardete F, Conde, Sílvia V

“…The carotid body (CB) is organized in clusters of lobules containing type I cells and type II cells, in a ratio of approximately 4:1. The CB undergoes…”
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Disclosing caffeine action on insulin sensitivity: Effects on rat skeletal muscle by Sacramento, Joana F., Ribeiro, Maria J., Yubero, Sara, Melo, Bernardete F., Obeso, Ana, Guarino, Maria P., Gonzalez, Constancio, Conde, Silvia V.

“…Caffeine, a non-selective adenosine antagonist, has distinct effects on insulin sensitivity when applied acutely or chronically. Herein, we investigated the…”
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Adenosine Mediates Hypercapnic Response in the Rat Carotid Body via A 2A and A 2B Receptors by Sacramento, Joana F, Melo, Bernardete F, Conde, Sílvia V

“…Adenosine is one of the key neurotransmitters involved in hypoxic signaling in the carotid body (CB), and it was recently found to have a modulatory role in…”
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