Plasmacytoid myoepithelioma of minor salivary glands: report of case with emphasis in the immunohistochemical findings

Plasmacytoid myoepithelioma of minor salivary glands: report of case with emphasis in the immunohistochemical findings

Myoepithelioma is a rare benign tumor of the salivary glands and is usually seen in the parotid gland and the minor salivary glands. It was once considered to be a type of pleomorphic adenoma (PA), but myoepitheliomas are today believed to be relatively aggressive tumors. Myoepitheliomas are most co...

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Bibliographic Details
Published in:Head & face medicine Vol. 7; no. 1; p. 24
Main Authors: Santos, Esaú P, Cavalcante, Danielle Rr, Melo, Allan Uc, Pereira, José C, Gomes, Margarete Z, Albuquerque, Jr, Ricardo Lc
Format: Journal Article
Language:English
Published: England BioMed Central Ltd 12-12-2011
BioMed Central
BMC
Subjects:
Adolescent
Analysis
Biomarkers, Tumor - analysis
Case Report
Dentistry
Diagnosis
Diagnosis, Differential
Diagnostic Imaging
Glial Fibrillary Acidic Protein - analysis
Humans
Immunohistochemistry
Male
Medical imaging
Medical research
Myoepithelioma - diagnosis
Myoepithelioma - metabolism
Neoplasm Staging
Plasmacytoma - diagnosis
Plasmacytoma - metabolism
S100 Proteins - analysis
Salivary Gland Neoplasms - diagnosis
Salivary Gland Neoplasms - metabolism
Salivary gland tumors
Salivary Glands, Minor
Studies
Tomography
Tumors
Vimentin - analysis
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Summary:Myoepithelioma is a rare benign tumor of the salivary glands and is usually seen in the parotid gland and the minor salivary glands. It was once considered to be a type of pleomorphic adenoma (PA), but myoepitheliomas are today believed to be relatively aggressive tumors. Myoepitheliomas are most common in young adults between the ages of 30 and 50 and there are very few cases reported in individuals less than 18 years of age. We report a case of myoepithelioma located in the hard palate in a 15-year-old Brazilian male. The tumor was composed of plasmacytoid myoepithelial cells. An analysis of the immunohistochemical profile of the tumor cells showed positivity for vimentin, S-100 protein, and glial fibrillary acidic protein (GFAP), but not for smooth muscle actin (α-SMA) and cytokeratin 14 (CK14). We report this case because of the rarity of this tumor, especially in adolescents. We also discuss the histological parameters of the differential diagnosis of this tumor as well as its immunohistochemical profile.
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ISSN:1746-160X
1746-160X
DOI:10.1186/1746-160X-7-24