Search Results - "Melnyk, James E"

The Innate Immune Protein Nod2 Binds Directly to MDP, a Bacterial Cell Wall Fragment by Grimes, Catherine Leimkuhler, Ariyananda, Lushanti De Zoysa, Melnyk, James E, O’Shea, Erin K

“…Mammalian Nod2 is an intracellular protein that is implicated in the innate immune response to the bacterial cell wall and is associated with the development…”
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Peptidoglycan Modifications Tune the Stability and Function of the Innate Immune Receptor Nod2 by Melnyk, James E, Mohanan, Vishnu, Schaefer, Amy K, Hou, Ching-Wen, Grimes, Catherine Leimkuhler

“…Natural modifications of peptidoglycan modulate the innate immune response. Peptidoglycan derivatives activate this response via the intracellular innate…”
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A SARS-CoV-2 protein interaction map reveals targets for drug repurposing by Gordon, David E, Jang, Gwendolyn M, Bouhaddou, Mehdi, Xu, Jiewei, Obernier, Kirsten, White, Kris M, O'Meara, Matthew J, Rezelj, Veronica V, Guo, Jeffrey Z, Swaney, Danielle L, Tummino, Tia A, Hüttenhain, Ruth, Kaake, Robyn M, Richards, Alicia L, Tutuncuoglu, Beril, Foussard, Helene, Batra, Jyoti, Haas, Kelsey, Modak, Maya, Kim, Minkyu, Haas, Paige, Polacco, Benjamin J, Braberg, Hannes, Fabius, Jacqueline M, Eckhardt, Manon, Soucheray, Margaret, Bennett, Melanie J, Cakir, Merve, McGregor, Michael J, Li, Qiongyu, Meyer, Bjoern, Roesch, Ferdinand, Vallet, Thomas, Mac Kain, Alice, Miorin, Lisa, Moreno, Elena, Naing, Zun Zar Chi, Zhou, Yuan, Peng, Shiming, Shi, Ying, Zhang, Ziyang, Shen, Wenqi, Kirby, Ilsa T, Melnyk, James E, Chorba, John S, Lou, Kevin, Dai, Shizhong A, Barrio-Hernandez, Inigo, Memon, Danish, Hernandez-Armenta, Claudia, Lyu, Jiankun, Mathy, Christopher J P, Perica, Tina, Pilla, Kala Bharath, Ganesan, Sai J, Saltzberg, Daniel J, Rakesh, Ramachandran, Liu, Xi, Rosenthal, Sara B, Calviello, Lorenzo, Venkataramanan, Srivats, Liboy-Lugo, Jose, Lin, Yizhu, Huang, Xi-Ping, Liu, YongFeng, Wankowicz, Stephanie A, Bohn, Markus, Safari, Maliheh, Ugur, Fatima S, Koh, Cassandra, Savar, Nastaran Sadat, Tran, Quang Dinh, Shengjuler, Djoshkun, Fletcher, Sabrina J, O'Neal, Michael C, Cai, Yiming, Chang, Jason C J, Broadhurst, David J, Klippsten, Saker, Sharp, Phillip P, Wenzell, Nicole A, Kuzuoglu-Ozturk, Duygu, Wang, Hao-Yuan, Trenker, Raphael, Young, Janet M, Cavero, Devin A, Hiatt, Joseph, Roth, Theodore L, Rathore, Ujjwal, Subramanian, Advait, Noack, Julia, Hubert, Mathieu, Stroud, Robert M, Frankel, Alan D, Rosenberg, Oren S, Verba, Kliment A, Agard, David A, Ott, Melanie, Emerman, Michael, Jura, Natalia

“…A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease 2019…”
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The splicing modulator sulfonamide indisulam reduces AR-V7 in prostate cancer cells by Melnyk, James E., Steri, Veronica, Nguyen, Hao G., Hann, Byron, Feng, Felix Y., Shokat, Kevan M.

“…[Display omitted] Alternative splicing of the androgen receptor (AR) is frequently observed in castration resistant prostate cancer (CRPC). One AR isoform, the…”
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Targeting a splicing-mediated drug resistance mechanism in prostate cancer by inhibiting transcriptional regulation by PKCβ1 by Melnyk, James E., Steri, Veronica, Nguyen, Hao G., Hwang, Y. Christina, Gordan, John D., Hann, Byron, Feng, Felix Y., Shokat, Kevan M.

“…The androgen receptor (AR) is a central driver of aggressive prostate cancer. After initial treatment with androgen receptor signaling inhibitors (ARSi),…”
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Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets by Haas, Kelsey M., McGregor, Michael J., Bouhaddou, Mehdi, Polacco, Benjamin J., Kim, Eun-Young, Nguyen, Thong T., Newton, Billy W., Urbanowski, Matthew, Kim, Heejin, Williams, Michael A. P., Rezelj, Veronica V., Hardy, Alexandra, Fossati, Andrea, Stevenson, Erica J., Sukerman, Ellie, Kim, Tiffany, Penugonda, Sudhir, Moreno, Elena, Braberg, Hannes, Zhou, Yuan, Metreveli, Giorgi, Harjai, Bhavya, Tummino, Tia A., Melnyk, James E., Soucheray, Margaret, Batra, Jyoti, Pache, Lars, Martin-Sancho, Laura, Carlson-Stevermer, Jared, Jureka, Alexander S., Basler, Christopher F., Shokat, Kevan M., Shoichet, Brian K., Shriver, Leah P., Johnson, Jeffrey R., Shaw, Megan L., Chanda, Sumit K., Roden, Dan M., Carter, Tonia C., Kottyan, Leah C., Chisholm, Rex L., Pacheco, Jennifer A., Smith, Maureen E., Schrodi, Steven J., Albrecht, Randy A., Vignuzzi, Marco, Zuliani-Alvarez, Lorena, Swaney, Danielle L., Eckhardt, Manon, Wolinsky, Steven M., White, Kris M., Hultquist, Judd F., Kaake, Robyn M., García-Sastre, Adolfo, Krogan, Nevan J.

“…Influenza A Virus (IAV) is a recurring respiratory virus with limited availability of antiviral therapies. Understanding host proteins essential for IAV…”
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Membrane Association Dictates Ligand Specificity for the Innate Immune Receptor NOD2 by Schaefer, Amy K, Melnyk, James E, Baksh, Michael M, Lazor, Klare M, Finn, M. G, Grimes, Catherine Leimkuhler

“…The human gut must regulate its immune response to resident and pathogenic bacteria, numbering in the trillions. The peptidoglycan component of the bacterial…”
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Crohn’s Disease Variants of Nod2 Are Stabilized by the Critical Contact Region of Hsp70 by Schaefer, Amy K, Wastyk, Hannah C, Mohanan, Vishnu, Hou, Ching-Wen, Lauro, Mackenzie L, Melnyk, James E, Burch, Jason M, Grimes, Catherine L

“…Nod2 is a cytosolic, innate immune receptor responsible for binding to bacterial cell wall fragments such as muramyl dipeptide (MDP). Upon binding, subsequent…”
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A SARS-CoV-2 protein interaction map reveals targets for drug repurposing by Gordon, David E., Jang, Gwendolyn M., Bouhaddou, Mehdi, Xu, Jiewei, Obernier, Kirsten, White, Kris M., O’Meara, Matthew J., Rezelj, Veronica V., Guo, Jeffrey Z., Swaney, Danielle L., Tummino, Tia A., Kaake, Robyn M., Richards, Alicia L., Tutuncuoglu, Beril, Foussard, Helene, Haas, Kelsey, Modak, Maya, Haas, Paige, Braberg, Hannes, Fabius, Jacqueline M., Eckhardt, Manon, Bennett, Melanie J., Cakir, Merve, McGregor, Michael J., Li, Qiongyu, Roesch, Ferdinand, Vallet, Thomas, Mac Kain, Alice, Miorin, Lisa, Moreno, Elena, Naing, Zun Zar Chi, Zhou, Yuan, Peng, Shiming, Shi, Ying, Zhang, Ziyang, Shen, Wenqi, Kirby, Ilsa T., Melnyk, James E., Chorba, John S., Lou, Kevin, Dai, Shizhong A., Barrio-Hernandez, Inigo, Memon, Danish, Hernandez-Armenta, Claudia, Perica, Tina, Ganesan, Sai J., Saltzberg, Daniel J., Calviello, Lorenzo, Venkataramanan, Srivats, Lin, Yizhu, Liu, YongFeng, Wankowicz, Stephanie A., Bohn, Markus, Safari, Maliheh, Ugur, Fatima S., Koh, Cassandra, Savar, Nastaran Sadat, Tran, Quang Dinh, Fletcher, Sabrina J., Cai, Yiming, Chang, Jason C. J., Broadhurst, David J., Klippsten, Saker, Sharp, Phillip P., Kuzuoglu-Ozturk, Duygu, Wang, Hao-Yuan, Trenker, Raphael, Cavero, Devin A., Hiatt, Joseph, Roth, Theodore L., Rathore, Ujjwal, Subramanian, Advait, Noack, Julia, Hubert, Mathieu, Stroud, Robert M., Frankel, Alan D., Verba, Kliment A., Agard, David A., Emerman, Michael, Jura, Natalia, von Zastrow, Mark, Verdin, Eric, Ashworth, Alan, Schwartz, Olivier, Mukherjee, Shaeri, Jacobson, Matt, Fujimori, Danica G., Ideker, Trey, Craik, Charles S., Floor, Stephen N., Fraser, James S., Gross, John D., Roth, Bryan L., Ruggero, Davide, Taunton, Jack, Beltrao, Pedro, Vignuzzi, Marco, Shokat, Kevan M., Shoichet, Brian K., Krogan, Nevan J.

“…A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease 2019…”
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The Global Phosphorylation Landscape of SARS-CoV-2 Infection by Bouhaddou, Mehdi, Memon, Danish, Meyer, Bjoern, White, Kris M., Rezelj, Veronica V., Correa Marrero, Miguel, Polacco, Benjamin J., Melnyk, James E., Ulferts, Svenja, Kaake, Robyn M., Batra, Jyoti, Richards, Alicia L., Stevenson, Erica, Gordon, David E., Rojc, Ajda, Obernier, Kirsten, Fabius, Jacqueline M., Soucheray, Margaret, Miorin, Lisa, Moreno, Elena, Koh, Cassandra, Tran, Quang Dinh, Hardy, Alexandra, Robinot, Rémy, Vallet, Thomas, Nilsson-Payant, Benjamin E., Hernandez-Armenta, Claudia, Dunham, Alistair, Weigang, Sebastian, Knerr, Julian, Modak, Maya, Quintero, Diego, Zhou, Yuan, Dugourd, Aurelien, Valdeolivas, Alberto, Patil, Trupti, Li, Qiongyu, Hüttenhain, Ruth, Cakir, Merve, Muralidharan, Monita, Kim, Minkyu, Jang, Gwendolyn, Tutuncuoglu, Beril, Hiatt, Joseph, Guo, Jeffrey Z., Xu, Jiewei, Bouhaddou, Sophia, Mathy, Christopher J.P., Gaulton, Anna, Manners, Emma J., Félix, Eloy, Shi, Ying, Goff, Marisa, Lim, Jean K., McBride, Timothy, O’Neal, Michael C., Cai, Yiming, Chang, Jason C.J., Broadhurst, David J., Klippsten, Saker, De wit, Emmie, Leach, Andrew R., Kortemme, Tanja, Shoichet, Brian, Ott, Melanie, Saez-Rodriguez, Julio, tenOever, Benjamin R., Mullins, R. Dyche, Fischer, Elizabeth R., Kochs, Georg, Grosse, Robert, García-Sastre, Adolfo, Vignuzzi, Marco, Johnson, Jeffery R., Shokat, Kevan M., Swaney, Danielle L., Beltrao, Pedro, Krogan, Nevan J.

“…The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions…”
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Abstract B066: Genome-wide CRISPR screens identify PTGES3 as a druggable AR modulator by Li, Haolong, Melnyk, James E., Fu, Becky Xu Hua, Feng, Siyu, Sjöström, Martin, Shrestha, Raunak, Zhang, Meng, Chesner, Lisa N., Shin, Hyun Jin, Calvert, Marsha, Chou, Jonathan, Das, Rajdeep, Egusa, Emily A., Winters, Aidan, Zhu, Jun, Maheshwari, Ashutosh, Hua, Junjie T., Alshalalfa, Mohammed, Chen, William S., Stohr, Bradley A., Siddiqui, Javed, Huang, Bo, Small, Eric J., Quigley, David A., Shokat, Kevan M., Gilbert, Luke A., Feng, Felix Y.

“…Abstract BACKGROUND The androgen receptor (AR) is the central therapeutic target in advanced prostate cancer (PCa). While treatments that directly target AR…”
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Synthesis and Application of Peptidoglycan Derivatives to Study the Recognition and Activation of the Innate Immune Receptor NOD2 by Melnyk, James E

“…The bacterial cell wall fragment, muramyl dipeptide, has been recognized since the 1970s as the minimal fragment necessary to initiate an innate immune…”
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