Search Results - "Melnick, M."

The International Consensus Classification of Mature Lymphoid Neoplasms: A Report from the Clinical Advisory Committee by Campo, Elias, Jaffe, Elaine S, Cook, James R, Quintanilla-Martinez, Leticia, Swerdlow, Steven H, Anderson, Kenneth C, Brousset, Pierre, Cerroni, Lorenzo, DeLeval, Laurence, Dirnhoffer, Stefan, Dogan, Ahmet, Feldman, Andrew L, Fend, Falko, Friedberg, Jonathan W, Gaulard, Philippe, Ghia, Paolo, Horwitz, Steven M, King, Rebecca L, Salles, Gilles, San-Miguel, Jesus, Seymour, John F, Treon, Steven P, Vose, Julie M, Zucca, Emanuele, Advani, Ranjana, Ansell, Stephen, Au, Wing-Yan, Barrionuevo, Carlos, Bergsagel, Leif, Chan, Wing C., Cohen, Jeffrey I, d’Amore, Francesco, Davies, Andrew, Falini, Brunangelo, Ghobrial, Irene M, Goodlad, John, Gribben, John G, Hsi, Eric D, Kahl, Brad S, Kim, Won-Seog, Kumar, Shaji, LaCasce, Ann S, Laurent, Camille, Lenz, George, Leonard, John P, Link, Michael P, Lopez-Guillermo, Armando, Manteca, Maria Victoria Mateos, Macintyre, Elizabeth, Melnick, Ari M, Morschhauser, Franck, Nakamura, Shigeo, Narbaitz, Marina, Paulovsky, Astrid, Pileri, Stefano A, Piris, Miguel, Pro, Barbara, Rajkumar, Vincent, Rosen, Steven T, Sander, Birgitta, Sehn, Laurie, Shipp, Margaret A, Smith, Sonali M, Staudt, Louis M, Thieblemont, Catherine, Tousseyn, Thomas, Wilson, Wyndham H, Yoshino, Tadashi, Zinzani, Pier-Luigi, Dreyling, Martin, Scott, David W, Winter, Jane N, Zelenetz, Andrew D

“…Since the publication of the Revised European-American Classification of mature lymphoid neoplasms in 1994, subsequent updates of the classification of mature…”
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A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations by Han, Dali, Lu, Xingyu, Shih, Alan H., Nie, Ji, You, Qiancheng, Xu, Meng Michelle, Melnick, Ari M., Levine, Ross L., He, Chuan

“…We present a highly sensitive and selective chemical labeling and capture approach for genome-wide profiling of 5-hydroxylmethylcytosine (5hmC) using DNA…”
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The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight by Garrett-Bakelman, Francine E, Darshi, Manjula, Green, Stefan J, Gur, Ruben C, Lin, Ling, Macias, Brandon R, McKenna, Miles J, Meydan, Cem, Mishra, Tejaswini, Nasrini, Jad, Piening, Brian D, Rizzardi, Lindsay F, Sharma, Kumar, Siamwala, Jamila H, Taylor, Lynn, Vitaterna, Martha Hotz, Afkarian, Maryam, Afshinnekoo, Ebrahim, Ahadi, Sara, Ambati, Aditya, Arya, Maneesh, Bezdan, Daniela, Callahan, Colin M, Chen, Songjie, Choi, Augustine M K, Chlipala, George E, Contrepois, Kévin, Covington, Marisa, Crucian, Brian E, De Vivo, Immaculata, Dinges, David F, Ebert, Douglas J, Feinberg, Jason I, Gandara, Jorge A, George, Kerry A, Goutsias, John, Grills, George S, Hargens, Alan R, Heer, Martina, Hillary, Ryan P, Hoofnagle, Andrew N, Hook, Vivian Y H, Jenkinson, Garrett, Jiang, Peng, Keshavarzian, Ali, Laurie, Steven S, Lee-McMullen, Brittany, Lumpkins, Sarah B, MacKay, Matthew, Maienschein-Cline, Mark G, Melnick, Ari M, Moore, Tyler M, Nakahira, Kiichi, Patel, Hemal H, Pietrzyk, Robert, Rao, Varsha, Saito, Rintaro, Salins, Denis N, Schilling, Jan M, Sears, Dorothy D, Sheridan, Caroline K, Stenger, Michael B, Tryggvadottir, Rakel, Urban, Alexander E, Vaisar, Tomas, Van Espen, Benjamin, Zhang, Jing, Ziegler, Michael G, Zwart, Sara R, Charles, John B, Kundrot, Craig E, Scott, Graham B I, Bailey, Susan M, Basner, Mathias, Feinberg, Andrew P, Lee, Stuart M C, Mason, Christopher E, Mignot, Emmanuel, Rana, Brinda K, Smith, Scott M, Snyder, Michael P, Turek, Fred W

“…To understand the health impact of long-duration spaceflight, one identical twin astronaut was monitored before, during, and after a 1-year mission onboard the…”
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Clinical and Biological Subtypes of B-cell Lymphoma Revealed by Microenvironmental Signatures by Kotlov, Nikita, Bagaev, Alexander, Revuelta, Maria V, Phillip, Jude M, Cacciapuoti, Maria Teresa, Antysheva, Zoya, Svekolkin, Viktor, Tikhonova, Ekaterina, Miheecheva, Natalia, Kuzkina, Natalia, Nos, Grigorii, Tabbo, Fabrizio, Frenkel, Felix, Ghione, Paola, Tsiper, Maria, Almog, Nava, Fowler, Nathan, Melnick, Ari M, Leonard, John P, Inghirami, Giorgio, Cerchietti, Leandro

“…Diffuse large B-cell lymphoma (DLBCL) is a biologically and clinically heterogeneous disease. Transcriptomic and genetic characterization of DLBCL has…”
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The Expanding Role of the BCL6 Oncoprotein as a Cancer Therapeutic Target by Cardenas, Mariano G, Oswald, Erin, Yu, Wenbo, Xue, Fengtian, MacKerell, Jr, Alexander D, Melnick, Ari M

“…BCL6 was initially discovered as an oncogene in B-cell lymphomas, where it drives the malignant phenotype by repressing proliferation and DNA damage…”
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Multi-tiered Reorganization of the Genome during B Cell Affinity Maturation Anchored by a Germinal Center-Specific Locus Control Region by Bunting, Karen L., Soong, T. David, Singh, Rajat, Jiang, Yanwen, Béguelin, Wendy, Poloway, David W., Swed, Brandon L., Hatzi, Katerina, Reisacher, William, Teater, Matt, Elemento, Olivier, Melnick, Ari M.

“…During the humoral immune response, B cells undergo a dramatic change in phenotype to enable antibody affinity maturation in germinal centers (GCs). Using…”
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Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition by Ennishi, Daisuke, Takata, Katsuyoshi, Béguelin, Wendy, Duns, Gerben, Mottok, Anja, Farinha, Pedro, Bashashati, Ali, Saberi, Saeed, Boyle, Merrill, Meissner, Barbara, Ben-Neriah, Susana, Woolcock, Bruce W, Telenius, Adèle, Lai, Daniel, Teater, Matt, Kridel, Robert, Savage, Kerry J, Sehn, Laurie H, Morin, Ryan D, Marra, Marco A, Shah, Sohrab P, Connors, Joseph M, Gascoyne, Randy D, Scott, David W, Melnick, Ari M, Steidl, Christian

“…We performed a genomic, transcriptomic, and immunophenotypic study of 347 patients with diffuse large B-cell lymphoma (DLBCL) to uncover the molecular basis…”
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EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop by Béguelin, Wendy, Rivas, Martín A., Calvo Fernández, María T., Teater, Matt, Purwada, Alberto, Redmond, David, Shen, Hao, Challman, Matt F., Elemento, Olivier, Singh, Ankur, Melnick, Ari M.

“…The EZH2 histone methyltransferase is required for B cells to form germinal centers (GC). Here we show that EZH2 mediates GC formation through repression of…”
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CD99 is a therapeutic target on disease stem cells in myeloid malignancies by Chung, Stephen S, Eng, William S, Hu, Wenhuo, Khalaj, Mona, Garrett-Bakelman, Francine E, Tavakkoli, Montreh, Levine, Ross L, Carroll, Martin, Klimek, Virginia M, Melnick, Ari M, Park, Christopher Y

“…Acute myeloid leukemia (AML) and the myelodysplastic syndromes (MDS) are initiated and sustained by self-renewing malignant stem cells; thus, eradication of…”
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Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions by Butler, Daniel, Mozsary, Christopher, Meydan, Cem, Foox, Jonathan, Rosiene, Joel, Shaiber, Alon, Danko, David, Afshinnekoo, Ebrahim, MacKay, Matthew, Sedlazeck, Fritz J., Ivanov, Nikolay A., Sierra, Maria, Pohle, Diana, Zietz, Michael, Gisladottir, Undina, Ramlall, Vijendra, Sholle, Evan T., Schenck, Edward J., Westover, Craig D., Hassan, Ciaran, Ryon, Krista, Young, Benjamin, Bhattacharya, Chandrima, Ng, Dianna L., Granados, Andrea C., Santos, Yale A., Servellita, Venice, Federman, Scot, Ruggiero, Phyllis, Fungtammasan, Arkarachai, Chin, Chen-Shan, Pearson, Nathaniel M., Langhorst, Bradley W., Tanner, Nathan A., Kim, Youngmi, Reeves, Jason W., Hether, Tyler D., Warren, Sarah E., Bailey, Michael, Gawrys, Justyna, Meleshko, Dmitry, Xu, Dong, Couto-Rodriguez, Mara, Nagy-Szakal, Dorottya, Barrows, Joseph, Wells, Heather, O’Hara, Niamh B., Rosenfeld, Jeffrey A., Chen, Ying, Steel, Peter A. D., Shemesh, Amos J., Xiang, Jenny, Thierry-Mieg, Jean, Thierry-Mieg, Danielle, Iftner, Angelika, Bezdan, Daniela, Sanchez, Elizabeth, Campion, Thomas R., Sipley, John, Cong, Lin, Craney, Arryn, Velu, Priya, Melnick, Ari M., Shapira, Sagi, Hajirasouliha, Iman, Borczuk, Alain, Iftner, Thomas, Salvatore, Mirella, Loda, Massimo, Westblade, Lars F., Cushing, Melissa, Wu, Shixiu, Levy, Shawn, Chiu, Charles, Schwartz, Robert E., Tatonetti, Nicholas, Rennert, Hanna, Imielinski, Marcin, Mason, Christopher E.

“…In less than nine months, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) killed over a million people, including >25,000 in New York City…”
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Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia by Li, Sheng, Garrett-Bakelman, Francine E, Chung, Stephen S, Sanders, Mathijs A, Hricik, Todd, Rapaport, Franck, Patel, Jay, Dillon, Richard, Vijay, Priyanka, Brown, Anna L, Perl, Alexander E, Cannon, Joy, Bullinger, Lars, Luger, Selina, Becker, Michael, Lewis, Ian D, To, Luen Bik, Delwel, Ruud, Löwenberg, Bob, Döhner, Hartmut, Döhner, Konstanze, Guzman, Monica L, Hassane, Duane C, Roboz, Gail J, Grimwade, David, Valk, Peter J M, D'Andrea, Richard J, Carroll, Martin, Park, Christopher Y, Neuberg, Donna, Levine, Ross, Melnick, Ari M, Mason, Christopher E

“…Genome-wide methylome sequencing of serial samples obtained from patients with acute myeloid leukemia reveals that epigenetic alleles and genetic alleles…”
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The Impact of Heterogeneity on Single-Cell Sequencing by Goldman, Samantha L, MacKay, Matthew, Afshinnekoo, Ebrahim, Melnick, Ari M, Wu, Shuxiu, Mason, Christopher E

“…The importance of diversity and cellular specialization is clear for many reasons, from population-level diversification, to improved resiliency to unforeseen…”
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Genomic profiling for clinical decision making in lymphoid neoplasms by de Leval, Laurence, Alizadeh, Ash A., Bergsagel, P. Leif, Campo, Elias, Davies, Andrew, Dogan, Ahmet, Fitzgibbon, Jude, Horwitz, Steven M., Melnick, Ari M., Morice, William G., Morin, Ryan D., Nadel, Bertrand, Pileri, Stefano A., Rosenquist, Richard, Rossi, Davide, Salaverria, Itziar, Steidl, Christian, Treon, Steven P., Zelenetz, Andrew D., Advani, Ranjana H., Allen, Carl E., Ansell, Stephen M., Chan, Wing C., Cook, James R., Cook, Lucy B., d’Amore, Francesco, Dirnhofer, Stefan, Dreyling, Martin, Dunleavy, Kieron, Feldman, Andrew L., Fend, Falko, Gaulard, Philippe, Ghia, Paolo, Gribben, John G., Hermine, Olivier, Hodson, Daniel J., Hsi, Eric D., Inghirami, Giorgio, Jaffe, Elaine S., Karube, Kennosuke, Kataoka, Keisuke, Klapper, Wolfram, Kim, Won Seog, King, Rebecca L., Ko, Young H., LaCasce, Ann S., Lenz, Georg, Martin-Subero, José I., Piris, Miguel A., Pittaluga, Stefania, Pasqualucci, Laura, Quintanilla-Martinez, Leticia, Rodig, Scott J., Rosenwald, Andreas, Salles, Gilles A., San-Miguel, Jesus, Savage, Kerry J., Sehn, Laurie H., Semenzato, Gianpietro, Staudt, Louis M., Swerdlow, Steven H., Tam, Constantine S., Trotman, Judith, Vose, Julie M., Weigert, Oliver, Wilson, Wyndham H., Winter, Jane N., Wu, Catherine J., Zinzani, Pier L., Zucca, Emanuele, Bagg, Adam, Scott, David W.

“…With the introduction of large-scale molecular profiling methods and high-throughput sequencing technologies, the genomic features of most lymphoid neoplasms…”
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The relationship between community food environment around schools and student meal participation: the role of school CEP participation status by Melnick, Emily M, Acciai, Francesco, Yedidia, Michael J, Ohri-Vachaspati, Punam

“…Despite the many benefits of school meals, not all students participate. One reason students may not participate in school meals is because they instead…”
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H1 histones control the epigenetic landscape by local chromatin compaction by Willcockson, Michael A., Healton, Sean E., Weiss, Cary N., Bartholdy, Boris A., Botbol, Yair, Mishra, Laxmi N., Sidhwani, Dhruv S., Wilson, Tommy J., Pinto, Hugo B., Maron, Maxim I., Skalina, Karin A., Toro, Laura Norwood, Zhao, Jie, Lee, Chul-Hwan, Hou, Harry, Yusufova, Nevin, Meydan, Cem, Osunsade, Adewola, David, Yael, Cesarman, Ethel, Melnick, Ari M., Sidoli, Simone, Garcia, Benjamin A., Edelmann, Winfried, Macian, Fernando, Skoultchi, Arthur I.

“…H1 linker histones are the most abundant chromatin-binding proteins 1 . In vitro studies indicate that their association with chromatin determines nucleosome…”
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EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis by Béguelin, Wendy, Teater, Matt, Gearhart, Micah D., Calvo Fernández, María Teresa, Goldstein, Rebecca L., Cárdenas, Mariano G., Hatzi, Katerina, Rosen, Monica, Shen, Hao, Corcoran, Connie M., Hamline, Michelle Y., Gascoyne, Randy D., Levine, Ross L., Abdel-Wahab, Omar, Licht, Jonathan D., Shaknovich, Rita, Elemento, Olivier, Bardwell, Vivian J., Melnick, Ari M.

“…The EZH2 histone methyltransferase mediates the humoral immune response and drives lymphomagenesis through formation of bivalent chromatin domains at critical…”
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EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation by Béguelin, Wendy, Popovic, Relja, Teater, Matt, Jiang, Yanwen, Bunting, Karen L., Rosen, Monica, Shen, Hao, Yang, Shao Ning, Wang, Ling, Ezponda, Teresa, Martinez-Garcia, Eva, Zhang, Haikuo, Zheng, Yupeng, Verma, Sharad K., McCabe, Michael T., Ott, Heidi M., Van Aller, Glenn S., Kruger, Ryan G., Liu, Yan, McHugh, Charles F., Scott, David W., Chung, Young Rock, Kelleher, Neil, Shaknovich, Rita, Creasy, Caretha L., Gascoyne, Randy D., Wong, Kwok-Kin, Cerchietti, Leandro, Levine, Ross L., Abdel-Wahab, Omar, Licht, Jonathan D., Elemento, Olivier, Melnick, Ari M.

“…The EZH2 histone methyltransferase is highly expressed in germinal center (GC) B cells and targeted by somatic mutations in B cell lymphomas. Here, we find…”
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EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis by Velichutina, Irina, Shaknovich, Rita, Geng, Huimin, Johnson, Nathalie A., Gascoyne, Randy D., Melnick, Ari M., Elemento, Olivier

“…EZH2 is the catalytic subunit of the PRC2 Polycomb complex and mediates transcriptional repression through its histone methyltransferase activity. EZH2 is…”
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Selective Inhibition of HDAC3 Targets Synthetic Vulnerabilities and Activates Immune Surveillance in Lymphoma by Mondello, Patrizia, Tadros, Saber, Teater, Matt, Fontan, Lorena, Chang, Aaron Y, Jain, Neeraj, Yang, Haopeng, Singh, Shailbala, Ying, Hsia-Yuan, Chu, Chi-Shuen, Ma, Man Chun John, Toska, Eneda, Alig, Stefan, Durant, Matthew, de Stanchina, Elisa, Ghosh, Sreejoyee, Mottok, Anja, Nastoupil, Loretta, Neelapu, Sattva S, Weigert, Oliver, Inghirami, Giorgio, Baselga, José, Younes, Anas, Yee, Cassian, Dogan, Ahmet, Scheinberg, David A, Roeder, Robert G, Melnick, Ari M, Green, Michael R

“…mutations are highly recurrent in B-cell lymphomas and either inactivate its histone acetyltransferase (HAT) domain or truncate the protein. Herein, we show…”
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Tee-ing up a New Follicular Lymphoma Classification System by Melnick, Ari M

“…In this issue of Blood Cancer Discovery, Han and colleagues find that follicular lymphomas (FL) can be stratified into distinct classes with clinical and…”
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