Search Results - "Melms, Arthur"

Clinical features, pathogenesis, and treatment of myasthenia gravis: a supplement to the Guidelines of the German Neurological Society by Melzer, Nico, Ruck, Tobias, Fuhr, Peter, Gold, Ralf, Hohlfeld, Reinhard, Marx, Alexander, Melms, Arthur, Tackenberg, Björn, Schalke, Berthold, Schneider-Gold, Christiane, Zimprich, Fritz, Meuth, Sven G., Wiendl, Heinz

“…Myasthenia gravis (MG) is an autoimmune antibody-mediated disorder of neuromuscular synaptic transmission. The clinical hallmark of MG consists of fluctuating…”
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The different roles of the thymus in the pathogenesis of the various myasthenia gravis subtypes by Marx, Alexander, Pfister, Frederick, Schalke, Berthold, Saruhan-Direskeneli, Güher, Melms, Arthur, Ströbel, Philipp

“…Abstract The thymus plays distinct roles in the pathogenesis of the different Myasthenia gravis (MG) subtypes. Inflammatory, neoplastic and age-related…”
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Anti-LRP4 autoantibodies in AChR- and MuSK-antibody-negative myasthenia gravis by Pevzner, Alexandra, Schoser, Benedikt, Peters, Katja, Cosma, Nicoleta-Carmen, Karakatsani, Andromachi, Schalke, Berthold, Melms, Arthur, Kröger, Stephan

“…Myasthenia gravis (MG) is an autoimmune disorder characterized by a defect in synaptic transmission at the neuromuscular junction causing fluctuating muscle…”
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Pivotal Role for CD16+ Monocytes in Immune Surveillance of the Central Nervous System by Waschbisch, Anne, Schröder, Sina, Schraudner, Dana, Sammet, Laura, Weksler, Babette, Melms, Arthur, Pfeifenbring, Sabine, Stadelmann, Christine, Schwab, Stefan, Linker, Ralf A

“…Monocytes represent a heterogeneous population of primary immune effector cells. At least three different subsets can be distinguished based on expression of…”
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Exploring the MHC-peptide matrix of central tolerance in the human thymus by Adamopoulou, Eleni, Tenzer, Stefan, Hillen, Nina, Klug, Paula, Rota, Ioanna A., Tietz, Silvia, Gebhardt, Madlen, Stevanovic, Stefan, Schild, Hansjörg, Tolosa, Eva, Melms, Arthur, Stoeckle, Christina

“…Ever since it was discovered that central tolerance to self is imposed on developing T cells in the thymus through their interaction with self-peptide major…”
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Cortical PIB binding in Lewy body disease is associated with Alzheimer-like characteristics by Maetzler, Walter, Liepelt, Inga, Reimold, Matthias, Reischl, Gerald, Solbach, Christoph, Becker, Clemens, Schulte, Claudia, Leyhe, Thomas, Keller, Stefanie, Melms, Arthur, Gasser, Thomas, Berg, Daniela

“…Abstract About one fourth of Lewy body disease (LBD) patients show cortical β-amyloid load, basically a hallmark of Alzheimer disease (AD). Using [11…”
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Fingolimod effects in neuroinflammation: Regulation of astroglial glutamate transporters? by Lee, De-Hyung, Seubert, Silvia, Huhn, Konstantin, Brecht, Lukas, Rötger, Caroline, Waschbisch, Anne, Schlachetzki, Johannes, Klausmeyer, Alice, Melms, Arthur, Wiese, Stefan, Winkler, Jürgen, Linker, Ralf A

“…Fingolimod is an oral sphingosine-1-phosphate-receptor modulator which reduces the recirculation of immune cells and may also directly target glial cells. Here…”
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Guideline for the management of myasthenic syndromes by Wiendl, Heinz, Abicht, Angela, Chan, Andrew, Della Marina, Adela, Hagenacker, Tim, Hekmat, Khosro, Hoffmann, Sarah, Hoffmann, Hans-Stefan, Jander, Sebastian, Keller, Christian, Marx, Alexander, Melms, Arthur, Melzer, Nico, Müller-Felber, Wolfgang, Pawlitzki, Marc, Rückert, Jens-Carsten, Schara-Schmidt, Ulrike, Schneider-Gold, Christiane, Schoser, Benedikt, Schreiner, Bettina, Schroeter, Michael, Schubert, Bettina, Sieb, Jörn-Peter, Zimprich, Fritz, Meisel, Andreas

“…Myasthenia gravis (MG), Lambert-Eaton myasthenic syndrome (LEMS), and congenital myasthenic syndromes (CMS) represent an etiologically heterogeneous group of…”
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Prednisolone Treatment Induces Tolerogenic Dendritic Cells and a Regulatory Milieu in Myasthenia Gravis Patients by Luther, Claudia, Adamopoulou, Eleni, Stoeckle, Christina, Brucklacher-Waldert, Verena, Rosenkranz, Daniela, Stoltze, Lars, Lauer, Sigrid, Poeschel, Simone, Melms, Arthur, Tolosa, Eva

“…FOXP3-expressing naturally occurring CD4(+)CD25(high) T regulatory cells (Treg) are relevant in the control of autoimmunity, and a defect in this cell…”
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Osteopontin is elevated in Parkinson’s disease and its absence leads to reduced neurodegeneration in the MPTP model by Maetzler, Walter, Berg, Daniela, Schalamberidze, Natalie, Melms, Arthur, Schott, Klaus, Mueller, Jakob C, Liaw, Lucy, Gasser, Thomas, Nitsch, Cordula

“…Abstract In the pathogenesis of Parkinson’s disease (PD), oxidative and nitrosative stress, apoptosis, mitochondrial dysfunction, and excitotoxicity are…”
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Genome-Wide Association Study of Late-Onset Myasthenia Gravis: Confirmation of TNFRSF11A and Identification of ZBTB10 and Three Distinct HLA Associations by Seldin, Michael F, Alkhairy, Omar K, Lee, Annette T, Lamb, Janine A, Sussman, Jon, Pirskanen-Matell, Ritva, Piehl, Fredrik, Verschuuren, Jan J G M, Kostera-Pruszczyk, Anna, Szczudlik, Piotr, McKee, David, Maniaol, Angelina H, Harbo, Hanne F, Lie, Benedicte A, Melms, Arthur, Garchon, Henri-Jean, Willcox, Nicholas, Gregersen, Peter K, Hammarstrom, Lennart

“…To investigate the genetics of late-onset myasthenia gravis (LOMG), we conducted a genome-wide association study imputation of>6 million single nucleotide…”
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Elevated Plasma Levels of Neuropeptide Proenkephalin A Predict Mortality and Functional Outcome in Ischemic Stroke by Doehner, Wolfram, MD, PhD, von Haehling, Stephan, MD, PhD, Suhr, Jennifer, Ebner, Nicole, MSc, Schuster, Andreas, MD, Nagel, Eike, MD, Melms, Arthur, MD, Wurster, Thomas, MD, Stellos, Konstantinos, MD, Gawaz, Meinrad, MD, Bigalke, Boris, MD

“…Objectives The purpose of this study was to investigate neuropeptides in patients presenting with symptoms of acute cerebrovascular disease. Background The…”
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Suppression of experimental autoimmune encephalomyelitis by interleukin-10 transduced neural stem/progenitor cells by Klose, Juliane, Schmidt, Nils Ole, Melms, Arthur, Dohi, Makoto, Miyazaki, Jun-ichi, Bischof, Felix, Greve, Bernhard

“…Neural stem/progenitor cells (NSPCs) have the ability to migrate into the central nervous system (CNS) to replace damaged cells. In inflammatory CNS disease,…”
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New poteintial serum biomarkers in multiple sclerosis identified by proteomic strategies by Amin, Bushra, Maurer, Andreas, Voelter, Wolfgang, Melms, Arthur, Kalbacher, Hubert

“…Proteome analysis of body fluids is a powerful tool to identify biomarkers of neurological disorders. Multiple sclerosis (MScl) is a chronic disabling disorder…”
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Serum and cerebrospinal fluid levels of transthyretin in Lewy body disorders with and without dementia by Maetzler, Walter, Tian, Youyong, Baur, Stephanie Maria, Gauger, Tina, Odoj, Bartholomäus, Schmid, Benjamin, Schulte, Claudia, Deuschle, Christian, Heck, Susanna, Apel, Anja, Melms, Arthur, Gasser, Thomas, Berg, Daniela

“…Parkinson's disease (PD) without (non-demented, PDND) and with dementia (PDD), and dementia with Lewy bodies (DLB) are subsumed under the umbrella term Lewy…”
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Isolation of myeloid dendritic cells and epithelial cells from human thymus by Stoeckle, Christina, Rota, Ioanna A, Tolosa, Eva, Haller, Christoph, Melms, Arthur, Adamopoulou, Eleni

“…In this protocol we provide a method to isolate dendritic cells (DC) and epithelial cells (TEC) from the human thymus. DC and TEC are the major antigen…”
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Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis by Tolosa, Eva, Li, Weijie, Yasuda, Yoshiyuki, Wienhold, Wolfgang, Denzin, Lisa K, Lautwein, Alfred, Driessen, Christoph, Schnorrer, Petra, Weber, Ekkehard, Stevanovic, Stefan, Kurek, Raffael, Melms, Arthur, Bromme, Dieter

“…Stepwise degradation of the invariant chain (Ii) is required for the binding of antigenic peptides to MHC class II molecules. Cathepsin (Cat) L in the murine…”
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No differences of butyrylcholinesterase protein activity and allele frequency in Lewy body diseases by Maetzler, Walter, Keller, Stefanie, Michelis, Joan, Koehler, Niklas, Stransky, Elke, Becker, Clemens, Schulte, Claudia, Melms, Arthur, Gasser, Thomas, Berg, Daniela

“…Abstract Butyrylcholinesterase (BChE) genotypes and protein (BuChE) activity, especially in combination with Apolipoprotein E4 (ApoE4), have been investigated…”
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International Consensus Guidance for Management of Myasthenia Gravis: 2020 Update by Narayanaswami, Pushpa, Sanders, Donald B., Wolfe, Gil, Benatar, Michael, Cea, Gabriel, Evoli, Amelia, Gilhus, Nils Erik, Illa, Isabel, Kuntz, Nancy L., Massey, Janice, Melms, Arthur, Murai, Hiroyuki, Nicolle, Michael, Palace, Jacqueline, Richman, David, Verschuuren, Jan

“…OBJECTIVETo update the 2016 formal consensus-based guidance for the management of myasthenia gravis (MG) based on the latest evidence in the literature…”
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International consensus guidance for management of myasthenia gravis: Executive summary by Sanders, Donald B, Wolfe, Gil I, Benatar, Michael, Evoli, Amelia, Gilhus, Nils E, Illa, Isabel, Kuntz, Nancy, Massey, Janice M, Melms, Arthur, Murai, Hiroyuki, Nicolle, Michael, Palace, Jacqueline, Richman, David P, Verschuuren, Jan, Narayanaswami, Pushpa

“…OBJECTIVE:To develop formal consensus-based guidance for the management of myasthenia gravis (MG). METHODS:In October 2013, the Myasthenia Gravis Foundation of…”
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