Search Results - "Melmed, Raun"

Pediatric Prolonged-Release Melatonin for Sleep in Children with Autism Spectrum Disorder: Impact on Child Behavior and Caregiver’s Quality of Life by Schroder, Carmen M., Malow, Beth A., Maras, Athanasios, Melmed, Raun D., Findling, Robert L., Breddy, John, Nir, Tali, Shahmoon, Shiri, Zisapel, Nava, Gringras, Paul

“…A randomized, 13-weeks, placebo-controlled double-blind study in 125 subjects aged 2–17.5 years with Autism Spectrum Disorder or Smith-Magenis syndrome and…”
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Autism and increased paternal age related changes in global levels of gene expression regulation by Alter, Mark D, Kharkar, Rutwik, Ramsey, Keri E, Craig, David W, Melmed, Raun D, Grebe, Theresa A, Bay, R Curtis, Ober-Reynolds, Sharman, Kirwan, Janet, Jones, Josh J, Turner, J Blake, Hen, Rene, Stephan, Dietrich A

“…A causal role of mutations in multiple general transcription factors in neurodevelopmental disorders including autism suggested that alterations in global…”
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A Randomized, Double-Blind, Placebo-Controlled Study of Guanfacine Extended Release in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder by Biederman, Joseph, Melmed, Raun D, Patel, Anil, McBurnett, Keith, Konow, Jennifer, Lyne, Andrew, Scherer, Noreen, SPD503 Study Group

“…With this study we assessed the efficacy and safety of an extended-release formulation of guanfacine compared with placebo for the treatment of children and…”
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The SOFIA Study: Negative Multi-center Study of Low Dose Fluoxetine on Repetitive Behaviors in Children and Adolescents with Autistic Disorder by Herscu, Paul, Handen, Benjamin L., Arnold, L. Eugene, Snape, Michael F., Bregman, Joel D., Ginsberg, Lawrence, Hendren, Robert, Kolevzon, Alexander, Melmed, Raun, Mintz, Mark, Minshew, Nancy, Sikich, Linmarie, Attalla, Ashraf, King, Brian, Owley, Thomas, Childress, Ann, Chugani, Harry, Frazier, Jean, Cartwright, Charles, Murphy, Tanya

“…Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that reduces obsessive–compulsive symptoms. There is limited evidence supporting its efficacy for…”
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STX209 (Arbaclofen) for Autism Spectrum Disorders: An 8-Week Open-Label Study by Erickson, Craig A., Veenstra-Vanderweele, Jeremy M., Melmed, Raun D., McCracken, James T., Ginsberg, Lawrence D., Sikich, Linmarie, Scahill, Lawrence, Cherubini, Maryann, Zarevics, Peter, Walton-Bowen, Karen, Carpenter, Randall L., Bear, Mark F., Wang, Paul P., King, Bryan H.

“…STX209 (arbaclofen), a selective GABA-B agonist, is hypothesized to modulate the balance of excitatory to inhibitory neurotransmission, and has shown…”
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The STARS Phase 2 Study: A Randomized Controlled Trial of Gaboxadol in Angelman Syndrome by Bird, Lynne M., Ochoa-Lubinoff, Cesar, Tan, Wen-Hann, Heimer, Gali, Melmed, Raun D., Rakhit, Amit, Visootsak, Jeannie, During, Matthew J., Holcroft, Christina, Burdine, Rebecca D., Kolevzon, Alexander, Thibert, Ronald L.

“…To evaluate safety and tolerability and exploratory efficacy end points for gaboxadol (OV101) compared with placebo in individuals with Angelman syndrome (AS)…”
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Safety and Efficacy of Memantine in Children with Autism: Randomized, Placebo-Controlled Study and Open-Label Extension by Aman, Michael G, Findling, Robert L, Hardan, Antonio Y, Hendren, Robert L, Melmed, Raun D, Kehinde-Nelson, Ola, Hsu, Hai-An, Trugman, Joel M, Palmer, Robert H, Graham, Stephen M, Gage, Allyson T, Perhach, James L, Katz, Ephraim

“…Abnormal glutamatergic neurotransmission is implicated in the pathophysiology of autism spectrum disorder (ASD). In this study, the safety, tolerability, and…”
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Plasma cytokine profiling in sibling pairs discordant for autism spectrum disorder by Napolioni, Valerio, Ober-Reynolds, Benjamin, Szelinger, Szabolcs, Corneveaux, Jason J, Pawlowski, Traci, Ober-Reynolds, Sharman, Kirwan, Janet, Persico, Antonio M, Melmed, Raun D, Craig, David W, Smith, Christopher J, Huentelman, Matthew J

“…Converging lines of evidence point to the existence of immune dysfunction in autism spectrum disorder (ASD), which could directly affect several key…”
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Efficacy and safety of memantine in children with autism spectrum disorder: Results from three phase 2 multicenter studies by Hardan, Antonio Y, Hendren, Robert L, Aman, Michael G, Robb, Adelaide, Melmed, Raun D, Andersen, Kristen A, Luchini, Rachel, Rahman, Rezwanur, Ali, Sanjida, Jia, X Daniel, Mallick, Madhuja, Lateiner, Jordan E, Palmer, Robert H, Graham, Stephen M

“…Three phase 2 trials were conducted to assess the efficacy and long-term safety of weight-based memantine extended release (ER) treatment in children with…”
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A Genetic Variant That Disrupts MET Transcription Is Associated with Autism by Campbell, Daniel B., Sutcliffe, James S., Ebert, Philip J., Militerni, Roberto, Bravaccio, Carmela, Trillo, Simona, Elia, Maurizio, Schneider, Cindy, Melmed, Raun, Sacco, Roberto, Persico, Antonio M., Levitt, Pat

“…There is strong evidence for a genetic predisposition to autism and an intense interest in discovering heritable risk factors that disrupt gene function. Based…”
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Evaluation of an artificial intelligence-based medical device for diagnosis of autism spectrum disorder by Megerian, Jonathan T., Dey, Sangeeta, Melmed, Raun D., Coury, Daniel L., Lerner, Marc, Nicholls, Christopher J., Sohl, Kristin, Rouhbakhsh, Rambod, Narasimhan, Anandhi, Romain, Jonathan, Golla, Sailaja, Shareef, Safiullah, Ostrovsky, Andrey, Shannon, Jennifer, Kraft, Colleen, Liu-Mayo, Stuart, Abbas, Halim, Gal-Szabo, Diana E., Wall, Dennis P., Taraman, Sharief

“…Autism spectrum disorder (ASD) can be reliably diagnosed at 18 months, yet significant diagnostic delays persist in the United States. This double-blinded,…”
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Two single arm trials of AKL-T01, a digital therapeutic for adolescents and adults with ADHD by Stamatis, Caitlin A, Farlow, Deborah N, Mercaldi, Catherine, Suh, Minny, Maple, Amanda, Savarese, Antonia, Childress, Ann, Melmed, Raun D, Kollins, Scott H

“…Inattention symptoms represent a key driver of functional impairment in ADHD and often persist into adolescence and adulthood, underscoring a need for novel…”
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Long-Term, Open-Label Extension Study of Guanfacine Extended Release in Children and Adolescents with ADHD by Biederman, Joseph, Melmed, Raun D., Patel, Anil, McBurnett, Keith, Donahue, Jessica, Lyne, Andrew

“…Guanfacine is a noradrenergic agonist that is believed to improve symptoms of attention-deficit/hyperactivity disorder (ADHD) through selective actions at…”
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A randomized, double-blind, placebo-controlled, parallel-group study of methylphenidate transdermal system in pediatric patients with attention-deficit/hyperactivity disorder by Findling, Robert L, Bukstein, Oscar G, Melmed, Raun D, López, Frank A, Sallee, Floyd R, Arnold, L Eugene, Pratt, Raymond D

“…To evaluate the efficacy and safety of methylphenidate transdermal system compared with placebo, using osmotic-release oral system (OROS) methylphenidate as a…”
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Oral Human Immunoglobulin for Children with Autism and Gastrointestinal Dysfunction: A Prospective, Open-Label Study by Schneider, Cindy K, Melmed, Raun D, Barstow, Leon E, Enriquez, F. Javier, Ranger-Moore, James, Ostrem, James A

“…Immunoglobulin secretion onto mucosal surfaces is a major component of the mucosal immune system. We hypothesized that chronic gastrointestinal (GI)…”
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A Double-Blind, Placebo-Controlled Trial of Oral Human Immunoglobulin for Gastrointestinal Dysfunction in Children with Autistic Disorder by Handen, Benjamin L., Melmed, Raun D., Hansen, Robin L., Aman, Michael G., Burnham, David L., Bruss, Jon B., McDougle, Christopher J.

“…Controversy exists regarding the extent and possible causal relationship between gastrointestinal symptoms and autism. A randomized, double-blind,…”
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A Method for Universal Screening of Elementary School Students: Development of the Social Challenges Screening Questionnaire by Smith, Christopher J., Pollard, Elena, Stein, Alexander J., Ober-Reynolds, Sharman, Kirwan, Janet, Malligo, Amanda, Matthews, Nicole L., Openden, Daniel, Melmed, Raun D.

“…Schools regularly screen students for hearing and vision impairments because they present impediments to academic progress. For the same reason, schools should…”
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Atomoxetine treatment in adolescents with attention-deficit/hyperactivity disorder by Wietecha, Linda A, Williams, David W, Herbert, Michael, Melmed, Raun D, Greenbaum, Michael, Schuh, Kory

“…This study compared two atomoxetine titration dosing schedules and two atomoxetine maintenance doses for treating adolescent attention-deficit/hyperactivity…”
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Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1 by Sacco, Roberto, Papaleo, Veruska, Hager, Jorg, Rousseau, Francis, Moessner, Rainald, Militerni, Roberto, Bravaccio, Carmela, Trillo, Simona, Schneider, Cindy, Melmed, Raun, Elia, Maurizio, Curatolo, Paolo, Manzi, Barbara, Pascucci, Tiziana, Puglisi-Allegra, Stefano, Reichelt, Karl-Ludvig, Persico, Antonio M

“…The TPH2 gene encodes the enzyme responsible for serotonin (5-HT) synthesis in the Central Nervous System (CNS). Stereotypic and repetitive behaviors are…”
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5.14 IMPROVING OBJECTIVE MEASURES OF ATTENTION IN TEST OF VARIABLES OF ATTENTION (T.O.V.A.) INTO NORMATIVE RANGES WITH AKL-T01, A DIGITAL TREATMENT FOR ATTENTION IN PEDIATRIC ADHD by Melmed, Raun D., Lutz, Jacqueline, Jina, Anil

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