Search Results - "Mellott, Adam J"

Physical Non-Viral Gene Delivery Methods for Tissue Engineering by Mellott, Adam J., Forrest, M. Laird, Detamore, Michael S.

“…The integration of gene therapy into tissue engineering to control differentiation and direct tissue formation is not a new concept; however, successful…”
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Supervised machine learning for automated classification of human Wharton's Jelly cells and mechanosensory hair cells by Kothapalli, Abihith, Staecker, Hinrich, Mellott, Adam J

“…Tissue engineering and gene therapy strategies offer new ways to repair permanent damage to mechanosensory hair cells (MHCs) by differentiating human Wharton's…”
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Evaluating polymeric biomaterials to improve next generation wound dressing design by Hodge, Jacob G, Zamierowski, David S, Robinson, Jennifer L, Mellott, Adam J

“…Abstract Wound healing is a dynamic series of interconnected events with the ultimate goal of promoting neotissue formation and restoration of anatomical…”
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Mesenchymal Stem Cell Extracellular Vesicles from Tissue-Mimetic System Enhance Epidermal Regeneration via Formation of Migratory Cell Sheets by Hodge, Jacob G, Robinson, Jennifer L, Mellott, Adam J

“…The secretome of adipose-derived mesenchymal stem cells (ASCs) offers a unique approach to understanding and treating wounds, including the critical process of…”
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Successful Treatment of Noise-Induced Hearing Loss by Mesenchymal Stromal Cells: An RNAseq Analysis of Protective/Repair Pathways by Warnecke, Athanasia, Harre, Jennifer, Shew, Matthew, Mellott, Adam J., Majewski, Igor, Durisin, Martin, Staecker, Hinrich

“…Mesenchymal stromal cells (MSCs) are an adult derived stem cell-like population that has been shown to mediate repair in a wide range of degenerative…”
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Tailoring the secretome composition of mesenchymal stem cells to augment specific functions of epidermal regeneration: an in vitro diabetic model by Hodge, Jacob G, Robinson, Jennifer L, Mellott, Adam J

“…Wound healing consists of a dynamic series of events that are highly dependent on paracrine factors for proper progression through the phases of wound healing…”
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A method for temporal-spatial multivariate genomic analysis of acute wound healing via tissue stratification: a porcine negative pressure therapy pilot study by Hodge, Jacob G, Gunewardena, Sumedha, Korentager, Richard A, Zamierowski, David S, Robinson, Jennifer L, Mellott, Adam J

“…Wound therapies are capable of modulating the complex molecular signaling profile of tissue regeneration. However traditional, bulk tissue analysis results in…”
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Enhancing wound healing dressing development through interdisciplinary collaboration by Hawthorne, Briauna, Simmons, J. Kai, Stuart, Braden, Tung, Robert, Zamierowski, David S., Mellott, Adam J.

“…The process of wound healing includes four phases: Hemostasis, inflammation, proliferation, and remodeling. Many wound dressings and technologies have been…”
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Tissue‐mimetic culture enhances mesenchymal stem cell secretome capacity to improve regenerative activity of keratinocytes and fibroblasts in vitro by Hodge, Jacob G., Decker, Heather E., Robinson, Jennifer L., Mellott, Adam J.

“…Mesenchymal stem/stromal cells (MSCs) are a heterogenous population of multipotent and highly secretory cells currently being investigated in the field of…”
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Novel hydrogel system eliminates subculturing and improves retention of nonsenescent mesenchymal stem cell populations by Hodge, Jacob G, Robinson, Jennifer L, Mellott, Adam J

“…To compare the physiological behavior of mesenchymal stem/stromal cells (MSCs) within an expandable tissue-mimetic 3D system relative to expansion in a…”
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Advances in translational inner ear stem cell research by Warnecke, Athanasia, Mellott, Adam J., Römer, Ariane, Lenarz, Thomas, Staecker, Hinrich

“…Stem cell research is expanding our understanding of developmental biology as well as promising the development of new therapies for a range of different…”
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Negative Pressure Wound Therapy in Maxillofacial Applications by Mellott, Adam J, Zamierowski, David S, Andrews, Brian T

“…Negative pressure wound therapy has greatly advanced the field of wound healing for nearly two decades, by providing a robust surgical adjunct technique for…”
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Investigation of human adipose‐derived stem‐cell behavior using a cell‐instructive polydopamine‐coated gelatin–alginate hydrogel by Pacelli, Settimio, Chakravarti, Aparna R., Modaresi, Saman, Subham, Siddharth, Burkey, Kyley, Kurlbaum, Cecilia, Fang, Madeline, Neal, Christopher A., Mellott, Adam J., Chakraborty, Aishik, Paul, Arghya

“…Hydrogels can be fabricated and designed to exert direct control over stem cells' adhesion and differentiation. In this study, we have investigated the use of…”
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Effects of Intraoperative Dexamethasone Administration in Adult Diabetic Burn Patients by Egan, Katie G, Allen, Andrea, Hendren, Gina, Mellott, Adam J, Bhavsar, Dhaval

“…The steroid dexamethasone is used intraoperatively to prevent postoperative nausea. Studies of intraoperative steroid use in diabetic patients have shown…”
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Microenvironmental support for cell delivery to the inner ear by Schulze, Jennifer, Sasse, Susanne, Prenzler, Nils, Staecker, Hinrich, Mellott, Adam J., Roemer, Ariane, Durisin, Martin, Lenarz, Thomas, Warnecke, Athanasia

“…Transplantation of mesenchymal stromal cells (MSC) presents a promising approach not only for the replacement of lost or degenerated cells in diseased organs…”
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Novel insights into negative pressure wound healing from an in situ porcine perspective by Hodge, Jacob G., Pistorio, Ashley L., Neal, Christopher A., Dai, Hongyan, Nelson‐Brantley, Jennifer G., Steed, Molly E., Korentager, Richard A., Zamierowski, David S., Mellott, Adam J.

“…Negative pressure wound therapy (NPWT) is used clinically to promote tissue formation and wound closure. In this study, a porcine wound model was used to…”
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The Use of Human Wharton's Jelly Cells for Cochlear Tissue Engineering by Mellott, Adam J, Detamore, Michael S, Staecker, Hinrich

“…Tissue engineering focuses on three primary components: stem cells, biomaterials, and growth factors. Together, the combination of these components is used to…”
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A Protocol for Decellularizing Mouse Cochleae for Inner Ear Tissue Engineering by Neal, Christopher A, Nelson-Brantley, Jennifer G, Detamore, Michael S, Staecker, Hinrich, Mellott, Adam J

“…In mammals, mechanosensory hair cells that facilitate hearing lack the ability to regenerate, which has limited treatments for hearing loss. Current…”
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Exploiting decellularized cochleae as scaffolds for inner ear tissue engineering by Mellott, Adam J, Shinogle, Heather E, Nelson-Brantley, Jennifer G, Detamore, Michael S, Staecker, Hinrich

“…Use of decellularized tissues has become popular in tissue engineering applications as the natural extracellular matrix can provide necessary physical cues…”
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Microsphere-based gradient implants for osteochondral regeneration: a long-term study in sheep by Mohan, Neethu, Gupta, Vineet, Sridharan, Banu Priya, Mellott, Adam J, Easley, Jeremiah T, Palmer, Ross H, Galbraith, Richard A, Key, Vincent H, Berkland, Cory J, Detamore, Michael S

“…The microfracture technique for cartilage repair has limited ability to regenerate hyaline cartilage. The current study made a direct comparison between…”
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