Search Results - "Mellor, Jack R."

Neuromodulation of hippocampal long-term synaptic plasticity by Palacios-Filardo, Jon, Mellor, Jack R

“…•Acetylcholine, noradrenaline, dopamine and serotonin all facilitate long-term synaptic plasticity.•Neuromodulators facilitate long-term synaptic plasticity by…”
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Memory trace replay: the shaping of memory consolidation by neuromodulation by Atherton, Laura A, Dupret, David, Mellor, Jack R

“…Highlights • Memory trace replay results from lingering excitability and synaptic plasticity. • The balance of replay mechanisms may be determined by…”
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Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output by Udakis, Matt, Pedrosa, Victor, Chamberlain, Sophie E. L., Clopath, Claudia, Mellor, Jack R.

“…The formation and maintenance of spatial representations within hippocampal cell assemblies is strongly dictated by patterns of inhibition from diverse…”
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Sharp-Wave Ripples Orchestrate the Induction of Synaptic Plasticity during Reactivation of Place Cell Firing Patterns in the Hippocampus by Sadowski, Josef H.L.P., Jones, Matthew W., Mellor, Jack R.

“…Place cell firing patterns reactivated during hippocampal sharp-wave ripples (SWRs) in rest or sleep are thought to induce synaptic plasticity and thereby…”
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Separable actions of acetylcholine and noradrenaline on neuronal ensemble formation in hippocampal CA3 circuits by Prince, Luke Y, Bacon, Travis, Humphries, Rachel, Tsaneva-Atanasova, Krasimira, Clopath, Claudia, Mellor, Jack R

“…In the hippocampus, episodic memories are thought to be encoded by the formation of ensembles of synaptically coupled CA3 pyramidal cells driven by sparse but…”
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Control of Ca2+ Influx and Calmodulin Activation by SK-Channels in Dendritic Spines by Griffith, Thom, Tsaneva-Atanasova, Krasimira, Mellor, Jack R

“…The key trigger for Hebbian synaptic plasticity is influx of Ca2+ into postsynaptic dendritic spines. The magnitude of [Ca2+] increase caused by NMDA-receptor…”
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The Small GTPase Arf1 Modulates Arp2/3-Mediated Actin Polymerization via PICK1 to Regulate Synaptic Plasticity by Rocca, Daniel L., Amici, Mascia, Antoniou, Anna, Blanco Suarez, Elena, Halemani, Nagaraj, Murk, Kai, McGarvey, Jennifer, Jaafari, Nadia, Mellor, Jack R., Collingridge, Graham L., Hanley, Jonathan G.

“…Inhibition of Arp2/3-mediated actin polymerization by PICK1 is a central mechanism to AMPA receptor (AMPAR) internalization and long-term depression (LTD),…”
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Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus by Dennis, Siobhan H, Pasqui, Francesca, Colvin, Ellen M, Sanger, Helen, Mogg, Adrian J, Felder, Christian C, Broad, Lisa M, Fitzjohn, Steve M, Isaac, John T R, Mellor, Jack R

“…Muscarinic M1 acetylcholine receptors (M1Rs) are highly expressed in the hippocampus, and their inhibition or ablation disrupts the encoding of spatial memory…”
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Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits by Palacios-Filardo, Jon, Udakis, Matt, Brown, Giles A., Tehan, Benjamin G., Congreve, Miles S., Nathan, Pradeep J., Brown, Alastair J. H., Mellor, Jack R.

“…Acetylcholine release in the hippocampus plays a central role in the formation of new memory representations. An influential but largely untested theory…”
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Coordinated Acetylcholine Release in Prefrontal Cortex and Hippocampus Is Associated with Arousal and Reward on Distinct Timescales by Teles-Grilo Ruivo, Leonor M., Baker, Keeley L., Conway, Michael W., Kinsley, Peter J., Gilmour, Gary, Phillips, Keith G., Isaac, John T.R., Lowry, John P., Mellor, Jack R.

“…Cholinergic neurotransmission throughout the neocortex and hippocampus regulates arousal, learning, and attention. However, owing to the poorly characterized…”
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Clathrin-independent trafficking of AMPA receptors by Glebov, Oleg O, Tigaret, Cezar M, Mellor, Jack R, Henley, Jeremy M

“…Membrane trafficking of AMPA receptors (AMPARs) is critical for neuronal function and plasticity. Although rapid forms of AMPAR internalization during…”
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Hippocampal-dependent navigation in head-fixed mice using a floating real-world environment by Stuart, Sarah A., Palacios-Filardo, Jon, Domanski, Aleks, Udakis, Matt, Duguid, Ian, Jones, Matt W., Mellor, Jack R.

“…Head-fixation of mice enables high-resolution monitoring of neuronal activity coupled with precise control of environmental stimuli. Virtual reality can be…”
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Facilitation of Long-Term Potentiation by Muscarinic M1 Receptors Is Mediated by Inhibition of SK Channels by Buchanan, Katherine A., Petrovic, Milos M., Chamberlain, Sophie E.L., Marrion, Neil V., Mellor, Jack R.

“…Muscarinic receptor activation facilitates the induction of synaptic plasticity and enhances cognitive function. However, the specific muscarinic receptor…”
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Acetylcholine modulates gamma frequency oscillations in the hippocampus by activation of muscarinic M1 receptors by Betterton, Ruth T., Broad, Lisa M., Tsaneva‐Atanasova, Krasimira, Mellor, Jack R., Poirazi, Panayiota

“…Modulation of gamma oscillations is important for the processing of information and the disruption of gamma oscillations is a prominent feature of…”
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Coordinated activation of distinct Ca2+ sources and metabotropic glutamate receptors encodes Hebbian synaptic plasticity by Tigaret, Cezar M., Olivo, Valeria, Sadowski, Josef H.L.P., Ashby, Michael C., Mellor, Jack R.

“…At glutamatergic synapses, induction of associative synaptic plasticity requires time-correlated presynaptic and postsynaptic spikes to activate postsynaptic…”
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Cholinergic modulation of hippocampal network function by Teles-Grilo Ruivo, Leonor M, Mellor, Jack R

“…Cholinergic septohippocampal projections from the medial septal area to the hippocampus are proposed to have important roles in cognition by modulating…”
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SUMOylation and phosphorylation of GluK2 regulate kainate receptor trafficking and synaptic plasticity by Chamberlain, Sophie E L, González-González, Inmaculada M, Wilkinson, Kevin A, Konopacki, Filip A, Kantamneni, Sriharsha, Henley, Jeremy M, Mellor, Jack R

“…Phosphorylation and SUMOylation of the kainate receptor (KAR) subunit GluK2 have both individually been shown to regulate KAR surface expression. Here the…”
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Author Correction: Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits by Palacios-Filardo, Jon, Udakis, Matt, Brown, Giles A., Tehan, Benjamin G., Congreve, Miles S., Nathan, Pradeep J., Brown, Alastair J. H., Mellor, Jack R.

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Analysis of hippocampal synaptic function in a rodent model of early life stress by Wilkinson, Matthew P, Robinson, Emma S J, Mellor, Jack R

“…Early life stress (ELS) is an important risk factor in the aetiology of depression. Developmental glucocorticoid exposure impacts multiple brain regions with…”
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Homeostatic Synaptic Scaling Is Regulated by Protein SUMOylation by Craig, Tim J., Jaafari, Nadia, Petrovic, Milos M., Rubin, Philip P., Mellor, Jack R., Henley, Jeremy M.

“…Homeostatic scaling allows neurons to alter synaptic transmission to compensate for changes in network activity. Here, we show that suppression of network…”
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