Search Results - "Mellor, Jack"

Neuromodulation of hippocampal long-term synaptic plasticity by Palacios-Filardo, Jon, Mellor, Jack R

“…•Acetylcholine, noradrenaline, dopamine and serotonin all facilitate long-term synaptic plasticity.•Neuromodulators facilitate long-term synaptic plasticity by…”
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Memory trace replay: the shaping of memory consolidation by neuromodulation by Atherton, Laura A, Dupret, David, Mellor, Jack R

“…Highlights • Memory trace replay results from lingering excitability and synaptic plasticity. • The balance of replay mechanisms may be determined by…”
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Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output by Udakis, Matt, Pedrosa, Victor, Chamberlain, Sophie E. L., Clopath, Claudia, Mellor, Jack R.

“…The formation and maintenance of spatial representations within hippocampal cell assemblies is strongly dictated by patterns of inhibition from diverse…”
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Sharp-Wave Ripples Orchestrate the Induction of Synaptic Plasticity during Reactivation of Place Cell Firing Patterns in the Hippocampus by Sadowski, Josef H.L.P., Jones, Matthew W., Mellor, Jack R.

“…Place cell firing patterns reactivated during hippocampal sharp-wave ripples (SWRs) in rest or sleep are thought to induce synaptic plasticity and thereby…”
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Acetylcholine Boosts Dendritic NMDA Spikes in a CA3 Pyramidal Neuron Model by Humphries, Rachel, Mellor, Jack R., O'Donnell, Cian

“…•Here, we estimate the effects of acetylcholine (ACh) on CA3 synaptic integration.•Higher input resistance in distal dendrites reduces the NMDA spike…”
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The Small GTPase Arf1 Modulates Arp2/3-Mediated Actin Polymerization via PICK1 to Regulate Synaptic Plasticity by Rocca, Daniel L., Amici, Mascia, Antoniou, Anna, Blanco Suarez, Elena, Halemani, Nagaraj, Murk, Kai, McGarvey, Jennifer, Jaafari, Nadia, Mellor, Jack R., Collingridge, Graham L., Hanley, Jonathan G.

“…Inhibition of Arp2/3-mediated actin polymerization by PICK1 is a central mechanism to AMPA receptor (AMPAR) internalization and long-term depression (LTD),…”
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Noradrenaline Release from Locus Coeruleus Terminals in the Hippocampus Enhances Excitation-Spike Coupling in CA1 Pyramidal Neurons Via β-Adrenoceptors by Bacon, Travis J, Pickering, Anthony E, Mellor, Jack R

“…Abstract Release of the neuromodulator noradrenaline signals salience during wakefulness, flagging novel or important experiences to reconfigure information…”
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Investigation of reward learning and feedback sensitivity in non-clinical participants with a history of early life stress by Wilkinson, Matthew Paul, Slaney, Chloe Louise, Mellor, Jack Robert, Robinson, Emma Susan Jane

“…Early life stress (ELS) is an important risk factor for the development of depression. Impairments in reward learning and feedback sensitivity are suggested to…”
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Kainate receptors and synaptic plasticity by Nair, Jithin D., Wilkinson, Kevin A., Henley, Jeremy M., Mellor, Jack R.

“…Synaptic plasticity has classically been characterized to involve the NMDA and AMPA subtypes of glutamate receptors, with NMDA receptors providing the key…”
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Control of Ca2+ Influx and Calmodulin Activation by SK-Channels in Dendritic Spines by Griffith, Thom, Tsaneva-Atanasova, Krasimira, Mellor, Jack R

“…The key trigger for Hebbian synaptic plasticity is influx of Ca2+ into postsynaptic dendritic spines. The magnitude of [Ca2+] increase caused by NMDA-receptor…”
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Separable actions of acetylcholine and noradrenaline on neuronal ensemble formation in hippocampal CA3 circuits by Prince, Luke Y, Bacon, Travis, Humphries, Rachel, Tsaneva-Atanasova, Krasimira, Clopath, Claudia, Mellor, Jack R

“…In the hippocampus, episodic memories are thought to be encoded by the formation of ensembles of synaptically coupled CA3 pyramidal cells driven by sparse but…”
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Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus by Dennis, Siobhan H, Pasqui, Francesca, Colvin, Ellen M, Sanger, Helen, Mogg, Adrian J, Felder, Christian C, Broad, Lisa M, Fitzjohn, Steve M, Isaac, John T R, Mellor, Jack R

“…Muscarinic M1 acetylcholine receptors (M1Rs) are highly expressed in the hippocampus, and their inhibition or ablation disrupts the encoding of spatial memory…”
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Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits by Palacios-Filardo, Jon, Udakis, Matt, Brown, Giles A., Tehan, Benjamin G., Congreve, Miles S., Nathan, Pradeep J., Brown, Alastair J. H., Mellor, Jack R.

“…Acetylcholine release in the hippocampus plays a central role in the formation of new memory representations. An influential but largely untested theory…”
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A Bayesian predictive approach for dealing with pseudoreplication by Lazic, Stanley E., Mellor, Jack R., Ashby, Michael C., Munafo, Marcus R.

“…Pseudoreplication occurs when the number of measured values or data points exceeds the number of genuine replicates, and when the statistical analysis treats…”
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Coordinated activation of distinct Ca(2+) sources and metabotropic glutamate receptors encodes Hebbian synaptic plasticity by Tigaret, Cezar M, Olivo, Valeria, Sadowski, Josef H L P, Ashby, Michael C, Mellor, Jack R

“…At glutamatergic synapses, induction of associative synaptic plasticity requires time-correlated presynaptic and postsynaptic spikes to activate postsynaptic…”
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Coordinated Acetylcholine Release in Prefrontal Cortex and Hippocampus Is Associated with Arousal and Reward on Distinct Timescales by Teles-Grilo Ruivo, Leonor M., Baker, Keeley L., Conway, Michael W., Kinsley, Peter J., Gilmour, Gary, Phillips, Keith G., Isaac, John T.R., Lowry, John P., Mellor, Jack R.

“…Cholinergic neurotransmission throughout the neocortex and hippocampus regulates arousal, learning, and attention. However, owing to the poorly characterized…”
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SUMOylation regulates kainate-receptor-mediated synaptic transmission by Henley, Jeremy M, Martin, Stéphane, Nishimune, Atsushi, Mellor, Jack R

“…The small ubiquitin-like modifier protein (SUMO) regulates transcriptional activity and the translocation of proteins across the nuclear membrane. The…”
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Clathrin-independent trafficking of AMPA receptors by Glebov, Oleg O, Tigaret, Cezar M, Mellor, Jack R, Henley, Jeremy M

“…Membrane trafficking of AMPA receptors (AMPARs) is critical for neuronal function and plasticity. Although rapid forms of AMPAR internalization during…”
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Hippocampal-dependent navigation in head-fixed mice using a floating real-world environment by Stuart, Sarah A., Palacios-Filardo, Jon, Domanski, Aleks, Udakis, Matt, Duguid, Ian, Jones, Matt W., Mellor, Jack R.

“…Head-fixation of mice enables high-resolution monitoring of neuronal activity coupled with precise control of environmental stimuli. Virtual reality can be…”
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Facilitation of Long-Term Potentiation by Muscarinic M1 Receptors Is Mediated by Inhibition of SK Channels by Buchanan, Katherine A., Petrovic, Milos M., Chamberlain, Sophie E.L., Marrion, Neil V., Mellor, Jack R.

“…Muscarinic receptor activation facilitates the induction of synaptic plasticity and enhances cognitive function. However, the specific muscarinic receptor…”
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