Search Results - "Mellon, R"

Defining Safe Use of Anesthesia in Children by Rappaport, Bob, Mellon, R. Daniel, Simone, Arthur, Woodcock, Janet

“…Anesthetic agents are commonly used for a variety of medical procedures in infants and children, but data from studies in animals suggest that under certain…”
Get full text

Magnetic Braking and Protostellar Disk Formation: The Ideal MHD Limit by Mellon, Richard R, Li, Zhi-Yun

“…Magnetic fields are usually considered dynamically important in star formation when the dimensionless mass-to-flux ratio is close to, or less than, unity. We…”
Get full text

Uniform assessment and ranking of opioid Mu receptor binding constants for selected opioid drugs by Volpe, Donna A., Tobin, Grainne A. McMahon, Mellon, R. Daniel, Katki, Aspandiar G., Parker, Robert J., Colatsky, Thomas, Kropp, Timothy J., Verbois, S. Leigh

“…The safe disposal of unused opioid drugs is an area of regulatory concern. While toilet flushing is recommended for some drugs to prevent accidental exposure,…”
Get full text

Use of Anesthetic Agents in Neonates and Young Children by Mellon, R Daniel, Simone, Arthur F., Rappaport, Bob A.

“…Some drugs used for sedation and anesthesia produce histopathologic central nervous system changes in juvenile animal models. These observations have raised…”
Get full text

Can We Panelize Seizure? by Roberts, Ruth, Authier, Simon, Mellon, R Daniel, Morton, Michael, Suzuki, Ikuro, Tjalkens, Ronald B, Valentin, Jean-Pierre, Pierson, Jennifer B

“…Abstract Seizure liability remains a significant cause of attrition in drug discovery and development, leading to loss of competitiveness, delays, and…”
Get full text

Toxicology Evaluation of Drugs Administered via Uncommon Routes: Intranasal, Intraocular, Intrathecal/Intraspinal, and Intra-Articular by Emami, Armaghan, Tepper, Jeff, Short, Brian, Yaksh, Tony L., Bendele, Alison M., Ramani, Thulasi, Cisternas, Alvaro F., Chang, Jay H., Mellon, R. Daniel

“…As the need for nasal, ocular, spinal, and articular therapeutic compounds increases, toxicology assessments of drugs administered via these routes play an…”
Get full text

Defining Safe Use of Anesthesia in Children by Rappaport, Bob, Mellon, R. Daniel, Simone, Arthur, Woodcock, Janet

Get full text

Biostimulant activity of brown seaweed species from Strangford Lough: compositional analyses of polysaccharides and bioassay of extracts using mung bean (Vigno mungo L.) and pak choi (Brassica rapa chinensis L.) by Sharma, S. H. S, Lyons, G, McRoberts, C, McCall, D, Carmichael, E, Andrews, F, Swan, R, McCormack, R, Mellon, R

“…The aims of this study were to characterise the composition of seaweed species and to evaluate the efficacy of aqueous extracts as plant biostimulants. Five…”
Get full text

HESI/FDA workshop on immunomodulators and cancer risk assessment: Building blocks for a weight-of-evidence approach by Lebrec, H., Brennan, F.R., Haggerty, H., Herzyk, D., Kamperschroer, C., Maier, C.C., Ponce, R., Preston, B.D., Weinstock, D., Mellon, R.D.

“…Profound immunosuppression (e.g., AIDS, transplant therapy) is epidemiologically associated with an increased cancer risk, and often with oncogenic viruses. It…”
Get full text

Compilation of International Regulatory Guidance Documents for Neuropathology Assessment During Nonclinical General Toxicity and Specialized Neurotoxicity Studies by Bolon, Brad, Bradley, Alys, Butt, Mark, Jensen, Karl, Krinke, Georg, Mellon, R. Daniel

“…Neuropathology analyses as end points during nonclinical efficacy and toxicity studies are challenging and require trained personnel and particular equipment…”
Get full text

Discovery of radio emission from the brown dwarf LP944-20 by Berger, E, Ball, S, Becker, K. M, Clarke, M, Frail, D. A, Fukuda, T. A, Hoffman, I. M, Mellon, R, Momjian, E, Murphy, N. W, Teng, S. H, Woodruff, T, Zauderer, B. A, Zavala, R. T

“…Brown dwarfs are not massive enough to sustain thermonuclear fusion of hydrogen at their centres, but are distinguished from gas-giant planets by their ability…”
Get full text

Immunomodulation and lymphoma in humans by Ponce, Rafael A, Gelzleichter, Thomas, Haggerty, Helen G, Heidel, Shawn, Holdren, Matthew S, Lebrec, Herve, Mellon, R Daniel, Pallardy, Marc

“…Observational and clinical studies have associated increased cancer risks with primary or acquired immunodeficiencies, autoimmunity, and use of immunotherapies…”
Get more information

Ulysses Cosmic Ray and Solar Particle Investigation/Kiel Electron Telescope observations: Charge sign dependence and spatial gradients during the 1990–2000 A > 0 solar magnetic cycle by Heber, B., Wibberenz, G., Potgieter, M. S., Burger, R. A., Ferreira, S. E. S., Müller-Mellon, R., Kunow, H., Ferrando, P., Raviart, A., Paizis, C., Lopate, C., McDonald, F. B., Cane, H. V.

“…Ulysses, launched in October 1990, began its second out‐of‐ecliptic orbit in September 1997. From 1991 to mid‐2000, solar polar magnetic field observations…”
Get full text

Evidence for central opioid receptors in the immunomodulatory effects of morphine: review of potential mechanism(s)of action by Mellon, R.Daniel, Bayer, Barbara M

“…This review will discuss studies demonstrating that activation of opioid receptors within the central nervous system alters various immune system parameters…”
Get full text

Continuing Education Course #3: Current Practices and Future Trends in Neuropathology Assessment for Developmental Neurotoxicity Testing by Bolon, Brad, Garman, Robert H., Gundersen, Hans Jørgen G., Allan Johnson, G., Kaufmann, Wolfgang, Krinke, Georg, Little, Peter B., Makris, Susan L., Mellon, R. Daniel, Sulik, Kathleen K., Jensen, Karl

“…The continuing education course on Developmental Neurotoxicity Testing (DNT) was designed to communicate current practices for DNT neuropathology, describe…”
Get full text

Evaluation of perennial ryegrass (Lolium perenne L.) for digestibility using thermogravimetry by Sharma, H.S.S., Mellon, R.M., Givens, D.I., Park, R.S., Archer, J., Lyons, G., Fletcher, H.

“…Studies have shown that thermogravimetric (TG) analysis can highlight differences in the combustion patterns of high, medium and poorly digestible ryegrass…”
Get full text

Detection of Circular Polarization in M81 by Brunthaler, A, Bower, G. C, Falcke, H, Mellon, R. R

Get full text

A Radio Survey for Linear and Circular Polarization in Low-Luminosity Active Galactic Nuclei by Bower, Geoffrey C, Falcke, Heino, Mellon, Richard R

Get full text

Clinical Investigation of Neuraxially Administered Drugs: A Regulatory Perspective by Schultheis, Lex W., Nikhar, Bindi M., Mellon, R Daniel, Doddapaneni, Suresh, Christodoulo, Danae D., Roca, Rigoberto, Rappaport, Bob A.

Get full text

The effects of morphine, nicotine and epibatidine on lymphocyte activity and hypothalamic-pituitary-adrenal axis responses by Mellon, R D, Bayer, B M

“…Acute administration of morphine alters various neuroendocrine and immune parameters via opioid receptors located within the central nervous system. Similar…”
Get more information