Search Results - "Mello, Stephano Spano"

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses by Kenzelmann Broz, Daniela, Spano Mello, Stephano, Bieging, Kathryn T, Jiang, Dadi, Dusek, Rachel L, Brady, Colleen A, Sidow, Arend, Attardi, Laura D

“…The mechanisms by which the p53 tumor suppressor acts remain incompletely understood. To gain new insights into p53 biology, we used high-throughput sequencing…”
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Gene Expression Profiles in Radiation Workers Occupationally Exposed to Ionizing Radiation by Fachin, Ana Lucia, Mello, Stephano Spano, Sandrin-Garcia, Paula, Junta, Cristina Moraes, Ghilardi-Netto, Thomaz, Donadi, Eduardo Antonio, Passos, Geraldo Aleixo da Silva, Sakamoto-Hojo, Elza Tiemi

“…Ionizing radiation(IR)imposes risks to human health and the environment. IR at low doses and low dose rates has the potency to initiate carcinogenesis…”
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The non-coding RNA BC1 is down-regulated in the hippocampus of Wistar Audiogenic Rat (WAR) strain after audiogenic kindling by Gitaí, Daniel Leite Goes, Fachin, Ana Lucia, Mello, Stephano Spanó, Elias, Carol Fuzachi, Bittencourt, Jackson Cioni, Leite, João Pereira, da Silva Passos, Geraldo Aleixo, Garcia-Cairasco, Norberto, Paçó-Larson, Maria Luisa

“…Abstract The aim of this study was to identify molecular pathways involved in audiogenic seizures in the epilepsy-prone Wistar Audiogenic Rat (WAR). For this,…”
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Unravelling mechanisms of p53-mediated tumour suppression by Bieging, Kathryn T., Mello, Stephano Spano, Attardi, Laura D.

“…There are many cellular outcomes attributable to p53 activation, but identifying which of these, or which combination of these, is important for tumour…”
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Differential gene expression of peripheral blood mononuclear cells from rheumatoid arthritis patients may discriminate immunogenetic, pathogenic and treatment features by Junta, Cristina Moraes, Sandrin-Garcia, Paula, Fachin-Saltoratto, Ana Lúcia, Mello, Stephano Spanó, Oliveira, Renê D.R, Rassi, Diane Meyre, Giuliatti, Silvana, Sakamoto-Hojo, Elza Tiemi, Louzada-Junior, Paulo, Donadi, Eduardo Antonio, Passos, Geraldo A.S

“…This study aimed to evaluate the association between the differential gene expression profiling of peripheral blood mononuclear cells of rheumatoid arthritis…”
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Comprehensive gene expression profiling in lungs of mice infected with Mycobacterium tuberculosis following DNAhsp65 immunotherapy by Zárate- Bladés, Carlos Rodrigo, Bonato, Vânia Luiza Deperon, da Silveira, Eduardo Lani Volpe, e Paula, Marina Oliveira, Junta, Cristina Moraes, Sandrin-Garcia, Paula, Fachin, Ana Lúcia, Mello, Stephano Spanó, Cardoso, Renato Sousa, de Sá Galetti, Fábio Cícero, Coelho-Castelo, Arlete Aparecida Martins, Ramos, Simone Gusmão, Donadi, Eduardo Antonio, Sakamoto-Hojo, Elza Tiemi, da Silva Passos, Geraldo Aleixo, Silva, Celio Lopes

“…Background The continued increase in tuberculosis (TB) rates and the appearance of extremely resistant Mycobacterium tuberculosis strains (XDR‐TB) worldwide…”
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Alterations in gene expression profiles correlated with cisplatin cytotoxicity in the glioma U343 cell line by Carminati, Patricia Oliveira, Mello, Stephano Spano, Fachin, Ana Lucia, Junta, Cristina Moraes, Sandrin-Garcia, Paula, Carlotti, Carlos Gilberto, Donadi, Eduardo Antonio, Passos, Geraldo Aleixo Silva, Sakamoto-Hojo, Elza Tiemi

“…Gliomas are the most common tumors in the central nervous system, the average survival time of patients with glioblastoma multiforme being about 1 year from…”
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Neat-en-ing up our understanding of p53 pathways in tumor suppression by Mello, Stephano Spano, Attardi, Laura Donatella

“…Although the p53 transcription factor has a well-established role in tumor suppression, little is known about how the non-coding targets of p53 mediate its…”
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Abstract C063: Inhibition of PRMT5 reduces aggressiveness in basal-like pancreatic ductal adenocarcinoma by Wang, Christina, Soares, Zamira Guerra, Esgdaille, Dakarai, Mello, Stephano Spano

“…The basal-like pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive type of mesenchymal PDAC that resists treatment and has a poor prognosis…”
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p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen by Valente, Liz J, Tarangelo, Amy, Li, Albert Mao, Naciri, Marwan, Raj, Nitin, Boutelle, Anthony M, Li, Yang, Mello, Stephano Spano, Bieging-Rolett, Kathryn, DeBerardinis, Ralph J, Ye, Jiangbin, Dixon, Scott J, Attardi, Laura D

“…The mechanisms by which TP53, the most frequently mutated gene in human cancer, suppresses tumorigenesis remain unclear. p53 modulates various cellular…”
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Abstract IA07: Deconstructing p53 pathways in tumor suppression by Mello, Stephano Spano, Bieging-Rolett, Kathryn, Kaiser, Alyssa, Valente, Elizabeth Joy, Raj, Nitin, McClendon, Jacob, Flowers, Brittany Maria, Morgens, David Warren, Bassik, Michael Cory, Attardi, Laura Donatella

“…The p53 transcription factor is a critical tumor suppressor in humans and mice. Despite this essential function, the molecular pathways through which p53 acts…”
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Abstract PR07: Deconstructing p53 transcriptional networks in pancreatic cancer suppression by Attardi, Laura D., Mello, Stephano Spano, Valente, Elizabeth J., Mazur, Pawel K., Raj, Nitin, Bieging-Rolett, Kathryn, Vogel, Hannes

“…The p53 transcription factor is mutated in the majority of human pancreatic cancers, underscoring its critical role in suppressing pancreatic cancer…”
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Abstract IA4: Deconstructing p53 pathways in vivo by Brady, Colleen A., Broz, Daniela Kenzelmann, Jiang, Dadi, Mello, Stephano Spano, Bieging, Kathryn, Johnson, Thomas M., Jarvis, Leslie A., Kozak, Margaret M., Basak, Shashwati, Attardi, Laura D.

“…The activation of the p53 protein by cellular stress signals is fundamental for tumor suppression but also promotes pathological states, such as provoking the…”
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Immunosuppressive therapy modulates T lymphocyte gene expression in patients with systemic lupus erythematosus by Pereira, Elayne, Tamia‐Ferreira, Márcia Cristina, Cardoso, Renato Sousa, Mello, Stephano Spanó, Sakamoto‐Hojo, Elza Tiemi, Passos, Geraldo A. S., Donadi, Eduardo Antonio

“…Summary To evaluate the T‐cell large‐scale differential gene expression in systemic lupus erythematosus (SLE) patients presenting with glomerulonephritis we…”
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