Search Results - "Mello, Fernando G"

An Essential Role for Alzheimer's-Linked Amyloid Beta Oligomers in Neurodevelopment: Transient Expression of Multiple Proteoforms during Retina Histogenesis by Bartley, Samuel C, Proctor, Madison T, Xia, Hongjie, Ho, Evelyn, Kang, Dong S, Schuster, Kristen, Bicca, Maíra A, Seckler, Henrique S, Viola, Kirsten L, Patrie, Steven M, Kelleher, Neil L, De Mello, Fernando G, Klein, William L

“…Human amyloid beta peptide (Aβ) is a brain catabolite that at nanomolar concentrations can form neurotoxic oligomers (AβOs), which are known to accumulate in…”
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Murine dopaminergic Müller cells restore motor function in a model of Parkinson's disease by Stutz, Bernardo, Conceição, Fabio Silva Lima, Santos, Luís Eduardo, Cadilhe, Daniel Veloso, Fleming, Renata L., Acquarone, Mariana, Gardino, Patrícia F., Melo Reis, Ricardo A., Dickson, Phillip W., Dunkley, Peter R., Rehen, Stevens, Houzel, Jean‐Christophe, Mello, Fernando G.

“…Müller cells constitute the main glial cell type in the retina where it interacts with virtually all cells displaying relevant functions to retinal physiology…”
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Activation of cannabinoid type 1 receptor (CB1) modulates oligodendroglial process branching complexity in rat hippocampal cultures stimulated by olfactory ensheathing glia-conditioned medium by Paes-Colli, Yolanda, Trindade, Priscila M P, Vitorino, Louise C, Piscitelli, Fabiana, Iannotti, Fabio Arturo, Campos, Raquel M P, Isaac, Alinny R, de Aguiar, Andrey Fabiano Lourenço, Allodi, Silvana, de Mello, Fernando G, Einicker-Lamas, Marcelo, de Siqueira-Santos, Raphael, Di Marzo, Vincenzo, Tannous, Bakhos A, Carvalho, Litia A, De Melo Reis, Ricardo A, Sampaio, Luzia S

“…The endocannabinoid system (ECS) refers to a complex cell-signaling system highly conserved among species formed by numerous receptors, lipid mediators…”
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Pituitary adenylyl cyclase‐activating polypeptide receptor re‐sensitization induces plastic changes in the dopaminergic phenotype in the mature avian retina by Fleming, Renata L., Silveira, Mariana S., Santos, Luís E., Henze, Isabela P., Gardino, Patrícia F., Mello, Maria Christina F., Mello, Fernando G.

“…Pituitary Adenylyl Cyclase‐Activating Polypeptide (PACAP) is a neuroactive peptide present in the avian retina where it activates adenylyl cyclase (AC) since…”
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Amyloid-β Decreases Nitric Oxide Production in Cultured Retinal Neurons: A Possible Mechanism for Synaptic Dysfunction in Alzheimer’s Disease? by Oliveira, Leandro T., Louzada, Paulo Roberto, de Mello, Fernando G., Ferreira, Sérgio T.

“…The neurotoxicity of the amyloid-β peptide (Aβ) appears to be, at least in part, related to pathological activation of glutamate receptors by Aβ aggregates…”
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Cannabinoid Receptor Type 1 Expression in the Developing Avian Retina: Morphological and Functional Correlation With the Dopaminergic System by da Silva Sampaio, Luzia, Kubrusly, Regina C C, Colli, Yolanda P, Trindade, Priscila P, Ribeiro-Resende, Victor T, Einicker-Lamas, Marcelo, Paes-de-Carvalho, Roberto, Gardino, Patricia F, de Mello, Fernando G, De Melo Reis, Ricardo A

“…The avian retina has been used as a model to study signaling by different neuro- and gliotransmitters. It is unclear how dopaminergic and cannabinoid systems…”
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Neurochemical plasticity of Müller cells after retinal injury: overexpression of GAT-3 may potentiate excitotoxicity by Schitine, Clarissa S, de Mello, Fernando G, Reis, Ricardo A M

“…[...]sonic hedgehog (Shh) has been shown to stimulate Müller glial proliferation through its receptor. [...]in mammals, few Müller glial cells injected in the…”
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Inhibition of Choline Acetyltransferase as a Mechanism for Cholinergic Dysfunction Induced by Amyloid-β Peptide Oligomers by Nunes-Tavares, Nilson, Santos, Luís Eduardo, Stutz, Bernardo, Brito-Moreira, Jordano, Klein, William L., Ferreira, Sérgio T., de Mello, Fernando G.

“…Dysregulated cholinergic signaling is an early hallmark of Alzheimer disease (AD), usually ascribed to degeneration of cholinergic neurons induced by the…”
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Secreted human amyloid precursor protein binds semaphorin 3a and prevents semaphorin-induced growth cone collapse by Magdesian, Margaret H, Gralle, Matthias, Guerreiro, Luiz H, Beltrão, Paulo José I, Carvalho, Milena M V F, Santos, Luís Eduardo da S, de Mello, Fernando G, Reis, Ricardo A M, Ferreira, Sérgio T

“…The amyloid precursor protein (APP) is well known for giving rise to the amyloid-β peptide and for its role in Alzheimer's disease. Much less is known,…”
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A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's‐associated pathologies by Cline, Erika N., Das, Arighno, Bicca, Maíra Assunção, Mohammad, Saad N., Schachner, Luis F., Kamel, Josette M., DiNunno, Nadia, Weng, Anthea, Paschall, Jacob D., Bu, Riana Lo, Khan, Faraz M., Rollins, Madeline G., Ives, Ashley N., Shekhawat, Gajendra, Nunes‐Tavares, Nilson, de Mello, Fernando G., Compton, Philip D., Kelleher, Neil L., Klein, William L.

“…Amyloid β oligomers (AβOs) accumulate early in Alzheimer's disease (AD) and experimentally cause memory dysfunction and the major pathologies associated with…”
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Prion Protein Modulates Monoaminergic Systems and Depressive-like Behavior in Mice by Beckman, Danielle, Santos, Luis E., Americo, Tatiana A., Ledo, Jose H., de Mello, Fernando G., Linden, Rafael

“…We sought to examine interactions of the prion protein (PrPC) with monoaminergic systems due to: the role of PrPC in both Prion and Alzheimer diseases, which…”
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Regulation of acetylcholine synthesis and storage by Prado, Marco A.M, Reis, Ricardo A.M, Prado, V.F, de Mello, Maria Christina, Gomez, Marcus V, de Mello, Fernando G

“…Acetylcholine is one of the major modulators of brain functions and it is the main neurotransmitter at the peripheral nervous system. Modulation of…”
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Neuro-glial cannabinoid receptors modulate signaling in the embryonic avian retina by Kubrusly, Regina C.C., Günter, Alexander, Sampaio, Luzia, Martins, Roberta Silva, Schitine, Clarissa S., Trindade, Priscila, Fernandes, Arlete, Borelli-Torres, Rosa, Miya-Coreixas, Vivian Sayuri, Rego Costa, Anna Carolina, Freitas, Hércules Rezende, Gardino, Patrícia F., de Mello, Fernando G., Calaza, Karin Costa, Reis, Ricardo A.M.

“…Endocannabinoids are endogenous lipids that activate selective G protein coupled receptors (CB1 and CB2), mostly found at neuronal presynaptic sites in the…”
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Neuroprotection against Aβ and glutamate toxicity by melatonin: Are GABA receptors involved? by Lima, Andréa C. Paula, Louzada, Paulo Roberto, De Mello, Fernando G., Ferreira, Sérgio T.

“…The beta -amyloid peptide (A beta ) is centrally related to the pathogenesis of Alzheimer's disease (AD). Previous studies have suggested that the…”
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Reply to Altered Monoaminergic Systems and Depressive-like Behavior in Congenic Prion Protein Knock-out Mice by Beckman, Danielle, Santos, Luis E., Americo, Tatiana A., Ledo, Jose H., de Mello, Fernando G., Linden, Rafael

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Exogenous β-amyloid peptide interferes with GLUT4 localization in neurons by Oliveira, Leandro T, Leon, Gabbriela V.O, Provance, D. William, de Mello, Fernando G, Sorenson, Martha M, Salerno, Verônica P

“…Abstract Aging represents a major risk factor for numerous illnesses that are of increasing importance to society, including two of the most prevalent:…”
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The putrescine analogue 1,4-diamino-2-butanone affects polyamine synthesis, transport, ultrastructure and intracellular survival in Leishmania amazonensis by Vannier-Santos, Marcos A, Menezes, Diego, Oliveira, Marcus F, de Mello, Fernando G

“…1 Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil 2 Instituto de Bioquímica Médica, Programa de Biologia Molecular e Biotecnologia,…”
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Taurine prevents the neurotoxicity of β‐amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders by Louzada, Paulo Roberto, Lima, Andréa C. Paula, Mendonca‐Silva, Dayde L., Noël, Francois, De Mello, Fernando G., Ferreira, Sérgio T.

“…Alzheimer's disease (AD) and several other neurological disorders have been linked to the overactivation of glutamatergic transmission and exci‐totoxicity as a…”
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Functional plasticity of GAT-3 in avian Müller cells is regulated by neurons via a glutamatergic input by Schitine, Clarissa S., Mendez-Flores, Orquidia G., Santos, Luis E., Ornelas, Isis, Calaza, Karin C., Pérez-Toledo, Karla, López-Bayghen, Esther, Ortega, Arturo, Gardino, Patrícia F., de Mello, Fernando G., Reis, Ricardo A.M.

“…•Glutamate decreases [3H]-GABA uptake in Müller glia via ionotropic receptors.•Glutamate increases intracellular Ca2+without causing toxicity to Müller…”
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Ampakine CX546 increases proliferation and neuronal differentiation in subventricular zone stem/progenitor cell cultures by Schitine, Clarissa, Xapelli, Sara, Agasse, Fabienne, Sardà-Arroyo, Laura, Silva, Ana P., De Melo Reis, Ricardo A., de Mello, Fernando G., Malva, João O.

“…Ampakines are chemical compounds known to modulate the properties of ionotropic α‐amino‐3‐hydroxyl‐5‐methyl‐4‐isoxazole‐propionate (AMPA)‐subtype glutamate…”
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