Search Results - "Mellibovsky Leonardo"

Microindentation for in vivo measurement of bone tissue material properties in atypical femoral fracture patients and controls by Güerri‐Fernández, Roberto C, Nogués, Xavier, Quesada Gómez, José M, Torres del Pliego, Elisa, Puig, Lluís, García‐Giralt, Natalia, Yoskovitz, Guy, Mellibovsky, Leonardo, Hansma, Paul K, Díez‐Pérez, Adolfo

“…Atypical femoral fractures (AFF) associated with long‐term bisphosphonates (LTB) are a growing concern. Their etiology is unknown, but bone material properties…”
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Bone Tissue Properties Measurement by Reference Point Indentation in Glucocorticoid‐Induced Osteoporosis by Mellibovsky, Leonardo, Prieto‐Alhambra, Daniel, Mellibovsky, Fernando, Güerri‐Fernández, Roberto, Nogués, Xavier, Randall, Connor, Hansma, Paul K, Díez‐Perez, Adolfo

“…ABSTRACT Glucocorticoids, widely used in inflammatory disorders, rapidly increase bone fragility and, therefore, fracture risk. However, common bone…”
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Microindentation for in vivo measurement of bone tissue mechanical properties in humans by Diez‐Perez, Adolfo, Güerri, Roberto, Nogues, Xavier, Cáceres, Enric, Peña, Maria Jesus, Mellibovsky, Leonardo, Randall, Connor, Bridges, Daniel, Weaver, James C, Proctor, Alexander, Brimer, Davis, Koester, Kurt J, Ritchie, Robert O, Hansma, Paul K

“…Bone tissue mechanical properties are deemed a key component of bone strength, but their assessment requires invasive procedures. Here we validate a new…”
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Bone tissue quality in patients with monoclonal gammopathy of uncertain significance by Orduna, Guillermina, Mellibovsky, Leonardo, Abella, Eugenia, Nogués, Xavier, Granero, Roser, García-Giralt, Natalia, Pineda-Moncusí, Marta, Güerri-Fernández, Roberto, Prieto-Alhambra, Daniel, Díez-Pérez, Adolfo

“…Introduction Monoclonal gammopathy of uncertain significance (MGUS) is highly prevalent in older adults and affects bone structure, with osteoporosis and…”
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Evolutionary and functional analyses of LRP5 in archaic and extant modern humans by Roca-Ayats, Neus, Maceda, Iago, Bruque, Carlos David, Martínez-Gil, Núria, Garcia-Giralt, Natàlia, Cozar, Mónica, Mellibovsky, Leonardo, Van Hul, Wim, Lao, Oscar, Grinberg, Daniel, Balcells, Susanna

“…The human lineage has undergone a postcranial skeleton gracilization (i.e. lower bone mass and strength relative to body size) compared to other primates and…”
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On the association between Chiari malformation type 1, bone mineral density and bone related genes by Martínez-Gil, Núria, Mellibovsky, Leonardo, Manzano-López González, Demián, Patiño, Juan David, Cozar, Monica, Rabionet, Raquel, Grinberg, Daniel, Balcells, Susanna

“…Chiari malformation type 1 (C1M) is a neurological disease characterized by herniation of the cerebellar tonsils below the foramen magnum. Cranial bone…”
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Genetic Analysis in a Familial Case With High Bone Mineral Density Suggests Additive Effects at Two Loci by Martínez‐Gil, Núria, Ovejero, Diana, Garcia‐Giralt, Natalia, Bruque, Carlos David, Mellibovsky, Leonardo, Nogués, Xavier, Rabionet, Raquel, Grinberg, Daniel, Balcells, Susanna

“…ABSTRACT Osteoporosis is the most common bone disease, characterized by a low bone mineral density (BMD) and increased risk of fracture. At the other end of…”
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Simvastatin and atorvastatin enhance gene expression of collagen type 1 and osteocalcin in primary human osteoblasts and MG-63 cultures by Ruiz-Gaspa, Silvia, Nogues, Xavier, Enjuanes, Anna, Monllau, Joan C., Blanch, Josep, Carreras, Ramon, Mellibovsky, Leonardo, Grinberg, Daniel, Balcells, Susana, Díez-Perez, Adolfo, Pedro-Botet, Juan

“…To clarify the mechanism of the stimulatory effect of statins on bone formation, we have assessed the effect of simvastatin and atorvastatin on osteoblast…”
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Expression profiling of microRNAs in human bone tissue from postmenopausal women by De-Ugarte, Laura, Serra-Vinardell, Jenny, Nonell, Lara, Balcells, Susana, Arnal, Magdalena, Nogues, Xavier, Mellibovsky, Leonardo, Grinberg, Daniel, Diez-Perez, Adolfo, Garcia-Giralt, Natalia

“…Bone tissue is composed of several cell types, which express their own microRNAs (miRNAs) that will play a role in cell function. The set of total miRNAs…”
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Genetic analysis of high bone mass cases from the BARCOS cohort of Spanish postmenopausal women by Sarrión, Patricia, Mellibovsky, Leonardo, Urreizti, Roser, Civit, Sergi, Cols, Neus, García-Giralt, Natàlia, Yoskovitz, Guy, Aranguren, Alvaro, Malouf, Jorge, Di Gregorio, Silvana, Río, Luís Del, Güerri, Roberto, Nogués, Xavier, Díez-Pérez, Adolfo, Grinberg, Daniel, Balcells, Susana

“…The aims of the study were to establish the prevalence of high bone mass (HBM) in a cohort of Spanish postmenopausal women (BARCOS) and to assess the…”
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Functional assessment of coding and regulatory variants from the DKK1 locus by Martínez-Gil, Núria, Roca-Ayats, Neus, Atalay, Nurgül, Pineda-Moncusí, Marta, Garcia-Giralt, Natàlia, Van Hul, Wim, Boudin, Eveline, Vives, Sergi, Vinardell, Mireia, Mellibovsky, Leonardo, Nogués, Xavier, Ovejero, Diana, Díez-Pérez, Adolfo, Grinberg, Daniel, Balcells, Susanna

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Erratum to: MiRNA profiling of whole trabecular bone: identification of osteoporosis-related changes in MiRNAs in human hip bones by De-Ugarte, Laura, Yoskovitz, Guy, Balcells, Susana, Güerri-Fernández, Robert, Martinez-Diaz, Santos, Mellibovsky, Leonardo, Urreizti, Roser, Nogués, Xavier, Grinberg, Daniel, García-Giralt, Natalia, Díez-Pérez, Adolfo

“…Funding for the work carried out in this article [1] was supported by grant FIS PI10/01537 and the Red Tematica de Investigacion Cooperativa en Envejecimiento…”
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A Haplotype‐Based Analysis of the LRP5 Gene in Relation to Osteoporosis Phenotypes in Spanish Postmenopausal Women by Agueda, Lídia, Bustamante, Mariona, Jurado, Susana, Garcia‐Giralt, Natalia, Ciria, Manel, Saló, Guillem, Carreras, Ramon, Nogués, Xavier, Mellibovsky, Leonardo, Díez‐Pérez, Adolfo, Grinberg, Daniel, Balcells, Susana

“…LRP5 encodes the low‐density lipoprotein receptor‐related protein 5, a transmembrane protein involved in Wnt signaling. LRP5 is an important regulator of…”
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GGPS1 Mutation and Atypical Femoral Fractures with Bisphosphonates by Roca-Ayats, Neus, Balcells, Susana, Garcia-Giralt, Natàlia, Falcó-Mascaró, Maite, Martínez-Gil, Núria, Abril, Josep F, Urreizti, Roser, Dopazo, Joaquín, Quesada-Gómez, José M, Nogués, Xavier, Mellibovsky, Leonardo, Prieto-Alhambra, Daniel, Dunford, James E, Javaid, Muhammad K, Russell, R. Graham, Grinberg, Daniel, Díez-Pérez, Adolfo

“…This letter describes the detection of GGPS1 and other mutations in three sisters who had atypical femoral fractures associated with long-term bisphosphonate…”
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Severe COVID-19 pneumonia in Good syndrome with a favorable outcome by Cos Esquius, Maria Lourdes, López Montesinos, Inmaculada, Gimeno Martinez, Ramón, Eguía Núñez, Jorge, Caballero-Rabasco, M. Araceli, Sánchez González, Blanca, López García, Alicia, Mellibovsky, Leonardo

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MiRNA profiling of whole trabecular bone: identification of osteoporosis-related changes in MiRNAs in human hip bones by De-Ugarte, Laura, Yoskovitz, Guy, Balcells, Susana, Güerri-Fernández, Robert, Martinez-Diaz, Santos, Mellibovsky, Leonardo, Urreizti, Roser, Nogués, Xavier, Grinberg, Daniel, García-Giralt, Natalia, Díez-Pérez, Adolfo

“…MicroRNAs (miRNAs) are important regulators of gene expression, with documented roles in bone metabolism and osteoporosis, suggesting potential therapeutic…”
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Fracture during oral bisphosphonate therapy is associated with deteriorated bone material strength index by Nogués, Xavier, Prieto-Alhambra, Daniel, Güerri-Fernández, Roberto, Garcia-Giralt, Natalia, Rodriguez-Morera, Jaime, Cos, Lourdes, Mellibovsky, Leonardo, Pérez, Adolfo Díez

“…Some patients experience fractures while receiving oral bisphosphonates (BPs) treatment. Clinical risk factors, advanced bone density loss, and…”
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Antibodies to SARS‐CoV‐2 in patients with primary immunodeficiencies treated with nonspecific immunoglobulins by Eguía, Jorge, Caballero‐Rabasco, M. Araceli, Cos, M. Lourdes, Grau, Santiago, Mellibovsky, Leonardo, Villegas, Eduardo, Blasco, Fabiola, Lemus, Ana, Crespo, Marta, Padilla, Eduardo, Gimeno, Ramón

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Alcohol‐induced bone disease in the absence of severe chronic liver damage by Díez, Adolfo, Puig, Jordi, Serrano, Sergi, Marin̄oso, Maria‐Lluisa, Bosch, Jaume, Marrugat, Jaume, Mellibovsky, Leonardo, Nogués, Xavier, Knobel, Hernando, Aubía, Jaume

“…To define and identify metabolic bone disease and mineral alterations induced by chronic heavy alcoholism in patients without severe liver damage, we studied a…”
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Functional characterization of the C7ORF76 genomic region, a prominent GWAS signal for osteoporosis in 7q21.3 by Roca-Ayats, Neus, Martínez-Gil, Núria, Cozar, Mónica, Gerousi, Marina, Garcia-Giralt, Natàlia, Ovejero, Diana, Mellibovsky, Leonardo, Nogués, Xavier, Díez-Pérez, Adolfo, Grinberg, Daniel, Balcells, Susanna

“…Genome-wide association studies (GWAS) have repeatedly identified genetic variants associated with bone mineral density (BMD) and osteoporotic fracture in…”
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