Search Results - "Melkko, J."

Immunoassay for intact amino-terminal propeptide of human type I procollagen by Melkko, J, Kauppila, S, Niemi, S, Risteli, L, Haukipuro, K, Jukkola, A, Risteli, J

“…We have developed quantitative immunoassays for the intact, trimeric amino-terminal propeptide of human type I procollagen (PINP) and its Col1 domain. Intact…”
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Radioimmunoassay of the carboxyterminal propeptide of human type I procollagen by Melkko, J, Niemi, S, Risteli, L, Risteli, J

“…Type I collagen is the most abundant collagen type in soft tissues and the only type found in mineralized bone. We established a rapid equilibrium…”
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Large performance variation does not affect outcome in the Finnish cervical cancer screening programme by Lönnberg, S., Nieminen, P., Kotaniemi-Talonen, L., Kujari, H., Melkko, J., Granroth, G., Vornanen, M., Pietiläinen, T., Arola, J., Tarkkanen, J., Luostarinen, T., Anttila, A.

“…S. Lönnberg, P. Nieminen, L. Kotaniemi‐Talonen, H. Kujari, J. Melkko, G. Granroth, M. Vornanen, T. Pietiläinen, J. Arola, J. Tarkkanen, T. Luostarinen and A…”
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Circulating C-terminal propeptide of type I procollagen is cleared mainly via the mannose receptor in liver endothelial cells by Smedsrød, B, Melkko, J, Risteli, L, Risteli, J

“…The fate of the circulating C-terminal propeptide of type I procollagen (PICP) was studied. Trace amounts of 125I-PICP administered intravenously to rats…”
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Clearance of NH2-terminal propeptides of types I and III procollagen is a physiological function of the scavenger receptor in liver endothelial cells by MELKKO, J, HELLEVIK, T, RISTELI, L, RISTELI, J, SMEDSRØD, B

“…This study was undertaken to determine the fate of circulating NH2-terminal propeptide of type I procollagen (PINP) in rats. Radiolabeled PINP showed a…”
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Acetaldehyde adducts in blood and bone marrow of patients with ethanol-induced erythrocyte abnormalities by Latvala, J, Parkkila, S, Melkko, J, Niemelä, O

“…Although alcohol abuse is known to cause a wide array of adverse effects on blood cell formation, the molecular mechanisms by which alcohol exerts its toxic…”
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Serum is a rich source of ligands for the scavenger receptor of hepatic sinusoidal endothelial cells by Hansen, Berit, Melkko, Jukka, Smedsrød, Bård

“…The present study was prompted by findings in our laboratory showing that serum effectively inhibits scavenger receptor (SR)-mediated endocytosis in hepatic…”
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Systemic glucocorticoids decrease the synthesis of type I and type III collagen in human skin in vivo, whereas isotretinoin treatment has little effect by Autio, P, Oikarinen, A, Melkko, J, Risteli, J, Risteli, L

“…The effects of systemic glucocorticoid and isotretinoin treatments on type I and type III collagen synthesis in intact skin were investigated by measuring the…”
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Predictive value of p53, Ki67 and TLR5 in neoplastic progression of Barrett’s esophagus: a matched case–control study by Helminen, Olli, Melkko, Jukka, Saarnio, Juha, Sihvo, Eero, Kuopio, Teijo, Ohtonen, Pasi, Kauppila, Joonas H., Karttunen, Tuomo J., Huhta, Heikki

“…Barrett’s esophagus progresses to high-grade dysplasia or cancer along the well-established metaplasia-dysplasia-adenocarcinoma sequence. The aim of this study…”
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Inflammation and prognosis in colorectal cancer by Klintrup, Kai, Mäkinen, Johanna M., Kauppila, Saila, Väre, Päivi O., Melkko, Jukka, Tuominen, Hannu, Tuppurainen, Karoliina, Mäkelä, Jyrki, Karttunen, Tuomo J., Mäkinen, Markus J.

“…Previous work has indicated that quantification of inflammatory cell reaction is of prognostic value in colorectal cancer. We evaluated the prognostic…”
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Thrombolytic therapy with streptokinase stimulates collagen breakdown by PEUHKURINEN, K. J, RISTELI, L, MELKKO, J. T, LINNALUOTO, M, JOUNELA, A, RISTELI, J

“…Plasmin is capable of degrading extracellular matrix components such as collagen in vitro. To evaluate the significance of this for in vivo conditions, we set…”
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The carboxy-terminal propeptide of type I procollagen in serum as a marker of bone formation: the effect of nandrolone decanoate and female sex hormones by Hassager, C, Jensen, L T, Johansen, J S, Riis, B J, Melkko, J, Pødenphant, J, Risteli, L, Christiansen, C, Risteli, J

“…Seventy-nine osteoporotic (prior forearm or vertebral fracture), but otherwise healthy, postmenopausal women (aged 55 to 75 years) were allocated to two…”
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Involvement of the subacromial bursa in impingement syndrome of the shoulder as judged by expression of tenascin-C and histopathology by HYVÖNEN, P, MELKKO, J, LEHTO, V. P, JALOVAARA, P

“…Our aim was to evaluate bursal involvement at different stages of the impingement syndrome as judged by conventional histopathological examination and…”
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Connective tissue response to major surgery and postoperative infection by Haukipuro, K, Melkko, J, Risteli, L, Kairaluoma, M I, Risteli, J

“…Type I and type III collagen are components of a healing wound, and major structural proteins. According to our previous study, wound fluid concentrations of…”
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Progression of human aortic valve stenosis is associated with tenascin-C expression by Satta, Jari, Melkko, Jukka, Pöllänen, Raimo, Tuukkanen, Juha, Pääkkö, Paavo, Ohtonen, Pasi, Mennander, Ari, Soini, Ylermi

“…We sought to assess tenascin-C (TN-C) expression and its possible pathobiological impact in human aortic valve stenosis. Tenascin-C, a large extracellular…”
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Advanced glycation end products are eliminated by scavenger-receptor-mediated endocytosis in hepatic sinusoidal Kupffer and endothelial cells by Smedsrød, B, Melkko, J, Araki, N, Sano, H, Horiuchi, S

“…Long-term incubation of proteins with glucose leads to the formation of advanced glycation end products (AGE). Physiological aspects of the catabolism of…”
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Characterization of a hyaluronan receptor on rat sinusoidal liver endothelial cells and its functional relationship to scavenger receptors by McCourt, Peter A. G., Smedsrød, Bård H., Melkko, Jukka, Johansson, Staffan

“…Hyaluronan is a widely distributed extracellular component of connective tissue with several mechanical and cell biological functions. The serum level of…”
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Matrix Metalloproteinase-9 (MMP-9) Immunoreactive Protein has Modest Prognostic Value in Locally Advanced Breast Carcinoma Patients Treated with an Adjuvant Antiestrogen Therapy by RAHKO, Eeva, JUKKOLA, Arja, MELKKO, Jukka, PAAVO, Pääkkö, BLOIGU, Risto, TALVENSAARI-MATTILA, Anne, TURPEENNIEMI-HUJANEN, Taina

“…Background: Matrix metalloproteinases (MMPs) are involved with tumour invasion and metastasis. Controversial data exists concerning the prognostic value of…”
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Scavenger-receptor-mediated endocytosis in endocardial endothelial cells of Atlantic cod Gadus morhua by Sørensen, K K, Melkko, J, Smedsrød, B

“…Scavenger receptors are multifunctional integral membrane proteins that mediate the endocytosis of many different macromolecular polyanions and also…”
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Increased amount of type III pN-collagen in human abdominal aortic aneurysms: Evidence for impaired type III collagen fibrillogenesis by Bode, Michaela K., Soini, Ylermi, Melkko, Jukka, Satta, Jari, Risteli, Leila, Risteli, Juha

“…Purpose: This study aimed to characterize the distribution of structural domains of type I and III collagens in the wall of abdominal aortic aneurysms (AAAs),…”
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